Left ventricular noncompaction: Clinical-echocardiographic study

Nikolić, Aleksandra; Jovović, Ljiljana; Tomić, Slobodan; Vuković, Milan

doi:10.2298/vsp1201032n

Cited by 3 publications

(1 citation statement)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However in healthy persons this can be also found. To separate benign LV trabeculation from pathological LVNC following diagnostic criteria is proposed [41] .…”

Section: Non-compactionmentioning

confidence: 99%

Cardiomyopathies: Evolution of pathogenesis concepts and potential for new therapies

Sisakian¹

2014

WJC

View full text Add to dashboard Cite

Cardiomyopathies are defined as diseases of the myocardium with associated structural and functional abnormalities. Knowledge of these pathologies for a long period was not clear in clinical practice due to uncertainties regarding definition, classification and clinical diagnosis. In recent decades, major advances have been made in the understanding of the molecular and genetic issues, pathophysiology, and clinical and radiological assessment of the diseases. Progress has been made also in management of several types of cardiomyopathy. Advances in the understanding of these diseases show that cardiomyopathies represent complex entities. Here, special attention is given to evolution of classification of cardiomyopathies, with the aim of assisting clinicians to look beyond schematic diagnostic labels in order to achieve more specific diagnosis. Knowledge of the genotype of cardiomyopathies has changed the pathophysiological understanding of their etiology and clinical course, and has become more important in clinical practice for diagnosis and prevention of cardiomyopathies. New approaches for clinical and prognostic assessment are provided based on contemporary molecular mechanisms of contribution in the pathogenesis of cardiomyopathies. The genotype-phenotype complex approach for assessment improves the clinical evaluation and management strategies of these pathologies. The review covers also the important role of imaging methods, particularly echocardiography, and cardiac magnetic resonance imaging in the evaluation of different types of cardiomyopathies. In summary, this review provides complex presentation of current state of cardiomyopathies from genetics to management aspects for cardiovascular specialists.

show abstract

“…However in healthy persons this can be also found. To separate benign LV trabeculation from pathological LVNC following diagnostic criteria is proposed [41] .…”

Section: Non-compactionmentioning

confidence: 99%

Cardiomyopathies: Evolution of pathogenesis concepts and potential for new therapies

Sisakian¹

2014

WJC

View full text Add to dashboard Cite

show abstract

Sudden death due to biventricular non-compaction cardiomyopathy in a 14-year-old

Cohen

Prahlow

2014

Forensic Sci Med Pathol

View full text Add to dashboard Cite

A 14-year-old African-American female with a long-standing medically and ablation-treated history of tachycardia with associated seizures died suddenly. Upon autopsy, evidence of gross non-compaction involving the left ventricle, as well as possible subtle non-compaction of the right ventricle was discovered. Microscopically, there was focal myocyte hypertrophy as well as myxoid connective tissue and subendocardial fibroelastosis in the areas affected by the non-compaction. Arrhythmia, precipitated by the underlying cardiomyopathy, led to this young girl's death. Non-compaction cardiomyopathy is a rare cardiac disorder which commonly goes undiagnosed until post-mortem, although diagnosis through echocardiogram, CT, or MRI is possible and there is criterion for diagnosis with each of these.

show abstract

A systematic review and meta-analysis of the prevalence of left ventricular non-compaction in adults

Ross

Jones

Blanch

et al. 2019

European Heart Journal

133

View full text Add to dashboard Cite

Aims To assess the reported prevalence of left ventricular non-compaction (LVNC) in different adult cohorts, taking in to consideration the role of diagnostic criteria and imaging modalities used. Methods and results A systematic review and meta-analysis of studies reporting LVNC prevalence in adults. Studies were sourced from Pre-Medline, Medline, and Embase and assessed for eligibility according to inclusion criteria. Eligible studies provided a prevalence of LVNC in adult populations (≥12 years). Studies were assessed, and data extracted by two independent reviewers. Fifty-nine eligible studies documenting LVNC in 67 unique cohorts were included. The majority of studies were assessed as moderate or high risk of bias. The pooled prevalence estimates for LVNC were consistently higher amongst cohorts diagnosed on cardiac magnetic resonance (CMR) imaging (14.79%, n = 26; I2 = 99.45%) compared with echocardiogram (1.28%, n = 36; I2 = 98.17%). This finding was unchanged when analysis was restricted to studies at low or moderate risk of bias. The prevalence of LVNC varied between disease and population representative cohorts. Athletic cohorts demonstrated high pooled prevalence estimates on echocardiogram (3.16%, n = 5; I2 = 97.37%) and CMR imaging (27.29%, n = 2). Conclusion Left ventricular non-compaction in adult populations is a poorly defined entity which likely encompasses both physiological adaptation and pathological disease. There is a higher prevalence with the introduction of newer imaging technologies, specifically CMR imaging, which identify LVNC changes more readily. The clinical significance of these findings remains unclear; however, there is significant potential for overdiagnosis, overtreatment, and unnecessary follow-up.

show abstract

Left ventricular noncompaction: Clinical-echocardiographic study

Abstract: Our results suggest that the real prevalence of LVNC may be higher than expected. New studies have to be done to solve this problem.

Cited by 3 publications

References 21 publications

Cardiomyopathies: Evolution of pathogenesis concepts and potential for new therapies

Cardiomyopathies: Evolution of pathogenesis concepts and potential for new therapies

Sudden death due to biventricular non-compaction cardiomyopathy in a 14-year-old

A systematic review and meta-analysis of the prevalence of left ventricular non-compaction in adults

Contact Info

Product

Resources

About