Left Ventricular Remodeling after Acute Myocardial Infarction and Biomarkers

Abstract

Considering to pathogenetic mechanisms of MI a few classical biomarkers have been used for diagnosis of MI or acute coronary syndrome. Lately novel markers have been identified to provide diagnostic and prognostic information and outcome of MI or acute coronary syndrome. A few novel biomarkers are overviewed in this article. A few novel biomarkers mentioned in this article showed significant relation to left ventricle remodelling and poor prognosis after myocardial infarction.

Post-Myocardial Infarction Ventricular Remodeling Biomarkers—The Key Link between Pathophysiology and Clinic

“…The final effect is an increased parietal stress which stimulates the mechanoreceptors and generates angiotensin II-releasing intracellular signals. After 72 h, there is a process mediated by the renin-angiotensin-aldosterone system and by neurohormonal activation, which causes changes in ventricular geometry, with dilation of the cavities and myocardial hypertrophy [11,12].…”

“…After 72 h, there is a process mediated by the renin-angiotensin-aldosterone system and by neurohormonal activation, which causes changes in ventricular geometry, with dilation of the cavities and myocardial hypertrophy. [11,12] The remodeling process can take from a few weeks to a few months, until a balance between the forces of distension and the resistance offered by the collagen fibers is obtained [1]. This balance is decisively influenced by [13]:…”