Left ventricular remodelling among Turner syndrome patients: insights from non-invasive 3D echocardiography-derived pressure–volume loop analysis

Oberhoffer, Felix Sebastian; Abdul‐Khaliq, Hashim; Jung, Anna-Maria; Rohrer, Tilman; Rahman, Mohamed Abdel

doi:10.1007/s00392-019-01579-8

Cited by 8 publications

(17 citation statements)

References 35 publications

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“…TS is associated with an elevated arterial stiffness (5)(6)(7)(8). In addition, a recent study of our department was able to show an increased LV afterload among TS patients (10). An augmentation in LV afterload due to vascular dysfunction, might explain the abnormal LV relaxation and latent LV systolic dysfunction among TS subjects shown in the present study.…”

Section: Conventional and Tdi Doppler In Ts Patients And Healthy Cont...supporting

confidence: 70%

“…The 3D LA Vmax/BSA is mainly dependant on the LV systolic function (14). In a prior study of our department we were able to demonstrate a significantly reduced LV systolic function in TS subjects visualised by a significantly lower longitudinal LV Strain assessed using 3D speckle tracking echocardiography (10).…”

Section: Two-dimensional Speckle Tracking Echocardiography and Three-...mentioning

confidence: 81%

“…TS is also associated with impairments of vascular function (5)(6)(7)(8). Furthermore, recent studies of our department revealed latent left ventricular (LV) systolic and diastolic dysfunctions in a cohort of TS patients, particularly in those with excess weight (9)(10)(11).…”

Section: Introductionmentioning

confidence: 98%

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Left atrial remodelling among Turner syndrome patients: novel insights from non-invasive 3D echocardiography

Rahman¹,

Jung²,

Zemlin³

et al. 2022

Quant Imaging Med Surg

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Background: To assess (I) the left atrial (LA) size, function and (II) the impact of excess weight on the LA and left ventricular (LV) performance in Turner syndrome (TS) patients.Methods: Twenty-five TS patients without congenital heart disease (CHD) and 19 healthy, age-matched controls underwent three-dimensional echocardiography (3DE) for LA volume measurements and twodimensional speckle tracking echocardiography (2DSTE) for LA strain measurements. LV performance was measured through LV Tei-index, indexed isovolumetric contraction (ICT/√RR interval), indexed relaxation (IVRT/√RR interval) and indexed filling time (FT/√RR interval). Results: Compared to healthy controls, normal-weight TS patients (n=16) displayed significantly increased heart rate (92.88±16.66 vs. 76.53±15.65 bpm; P=0.005), reduced indexed LV filling time (11.67±2.55 vs. 15.16±5.07; P=0.018), reduced 3D maximum LA volume at LV end systole/BSA (16.74±5.00 vs. 19.89±4.32 mL/m 2 ; P=0.05), reduced 3D LA total emptying volume/BSA [10.04 (5.05/18.46) vs. 13.11 (7.69/18.46) mL/m 2 ; P=0.001] and reduced 3D LA active emptying volume/BSA [2.61 (0.1/3.82) vs. 3.44 (1.64/6.37) mL/m 2 ; P=0.006]. Compared to normal-weight TS patients, overweight/obese TS patients (n=9) showed impaired LV Tei-index [0.38 (0.26/0.55) vs. 0.27 (0.07/0.41); P=0.009], prolonged indexed IVRT (2.04±0.72 vs. 1.30±0.64; P=0.015), prolonged indexed ICT [1.96 (1.57/2.73) vs. 1.29 (0.35/2.69); P=0.009] and increased 3D LA active emptying volume/BSA (3.38±1.21 vs. 2.29±1.07 mL/m 2 ; P=0.032).Conclusions: Normal-weight TS patients with increased heart rate and reduced LV filling time display subtle LV diastolic dysfunction in the form of reduced LA reservoir and pump function. Manifested systolic and diastolic LV dysfunction among overweight TS patients is partially compensated through an increase in LA active pump function.

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Section: Conventional and Tdi Doppler In Ts Patients And Healthy Cont...supporting

confidence: 70%

Section: Two-dimensional Speckle Tracking Echocardiography and Three-...mentioning

confidence: 81%

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Left atrial remodelling among Turner syndrome patients: novel insights from non-invasive 3D echocardiography

Rahman¹,

Jung²,

Zemlin³

et al. 2022

Quant Imaging Med Surg

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“…Detailed information on the vascular function assessment has been previously described [ 6 , 29 , 30 ] and is shortly summarized as follows.…”

Section: Methodsmentioning

confidence: 99%

MicroRNA-126-3p/5p and Aortic Stiffness in Patients with Turner Syndrome

et al. 2022

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Background: Turner syndrome (TS) is a relatively rare X-chromosomal disease with increased cardiovascular morbidity and mortality. This study aimed to identify whether the circulating miR-126-3p/5p are involved in the pathophysiology of vascular dysfunction in TS. Methods: Using the RT-qPCR, the abundance levels of miR-126-3p and miR-126-5p were determined in 33 TS patients and 33 age-matched healthy volunteers (HVs). Vascular screening, including the assessment of blood pressure, pulse wave velocity, augmentation index, aortic deformation, arterial distensibility, and arterial elastance, was conducted in TS patients and HVs. Results: The abundance levels of miR-126-3p and miR-126-5p were significantly higher in TS patients compared to HVs (p < 0.0001). Within the TS cohort, miR-126-3p/5p correlated significantly with aortic deformation (r = 0.47, p = 0.01; r = 0.48, p < 0.01) and arterial distensibility (r = 0.55, p < 0.01; r = 0.48, p < 0.01). In addition, a significant negative correlation was demonstrated between miR-126-3p and arterial elastance (r = −0.48, p = 0.01). The receiver operating characteristic analysis showed that miR-126-3p and miR-126-5p separated the tested groups with high sensitivity and specificity. Conclusions: The abundance levels of miR-126-3p and miR-126-5p were significantly higher in TS patients compared to HVs. Within the TS cohort, a lower abundance level of miR-126-3p and miR-126-5p was linked with a significantly higher aortic stiffness.

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“…In addition to this, virtually the entire work fails to incorporate deep learning and machine learning techniques and lacks a substantial dataset. 23–26…”

Section: Introductionmentioning

confidence: 99%

Detection of Turner syndrome using hand X-ray using anchor based links segmentation method

Ramachandran

Gobalakrishnan

Chokkalingam³

2022

Proc Inst Mech Eng H

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Turner Syndrome (TS) is a chromosomal disorder, wherein the female’s growth is impacted. Immature ovaries, low stature, and heart abnormalities are a range of developmental and medical issues due to TS. The condition of TS might be detected prior to birth, throughout infancy or in the early years of life. The diagnosis of TS in girls with modest symptoms and indications is sometimes deferred until they reach adolescence or become young adults. This study presents an algorithm to segment the hand digital X-ray image in children with TS. In medical image and computer vision examination, image segmentation is demanding, and very crucial. Prevailing segmentation algorithms even now suffer from common segmentation issues including under-segmentation, over-segmentation, and spurious or non-closed edges, regardless of the several years of studies. In this paper, Anchor Based Link (ABL) segmentation approach is proposed to detect TS based on fourth Metacarpal bone from left hand X-ray images. The detection of TS is demonstrated based upon the comparison of proposed approach with existing watershed segmentation and Gaussian-Mixture-Model-based Hidden-Markov-Random-Field (GMM-HMRF) method. The proposed approach attains better segmentation based on the ratio of height and width of left fourth finger that is analyzed for normal children and children having TS with the help of edge pixel present in the metacarpal bone that has been segmented. The suggested method is verified on fifty (50) sample X-ray hand images of carpal bones, providing 0.60 ± 0.02 as an average Dice coefficient.

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Left ventricular remodelling among Turner syndrome patients: insights from non-invasive 3D echocardiography-derived pressure–volume loop analysis

Cited by 8 publications

References 35 publications

Left atrial remodelling among Turner syndrome patients: novel insights from non-invasive 3D echocardiography

Left atrial remodelling among Turner syndrome patients: novel insights from non-invasive 3D echocardiography

MicroRNA-126-3p/5p and Aortic Stiffness in Patients with Turner Syndrome

Detection of Turner syndrome using hand X-ray using anchor based links segmentation method

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