Left Ventricular Reverse Remodeling in Long-Term (&gt;12 Years) Survivors With Idiopathic Dilated Cardiomyopathy

Matsumura, Yuichi; Hoshikawa-Nagai, Eri; Kubo, Toru; Yamasaki, Naohito; Furuno, Takashi; Kitaoka, Hiroaki; Takata, Jun; Sugiura, Tetsuro; Doi, Yoshinori

doi:10.1016/j.amjcard.2012.08.056

Cited by 39 publications

(29 citation statements)

References 22 publications

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“…Spontaneous improvement in symptoms and potentially complete recovery of left ventricular (LV) function is reported in approximately 25–70% of DCM patients. 3–10 In this review article, we discuss the capacity for recovery in DCM, the prognostic implications of this recovery, and potential predictors for myocardial remodeling. …”

Section: Introductionmentioning

confidence: 99%

Myocardial remodelling and recovery in dilated cardiomyopathy

Tayal

Prasad

2017

JRSM Cardiovascular Disease

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Myocardial reverse remodeling has been reported to occur in 25–70% of patients with dilated cardiomyopathy. It is not yet fully understood whether remodeling represents disease remission or cure and which hearts retain this capacity to recover. In this review article we discuss the capacity for recovery in DCM, the prognostic implications of this recovery and potential clinical and imaging predictors for myocardial remodeling.

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Section: Introductionmentioning

confidence: 99%

Myocardial remodelling and recovery in dilated cardiomyopathy

Tayal

Prasad

2017

JRSM Cardiovascular Disease

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“…With the development of medicine, survival of adults with idiopathic DCM has improved in recent decades, with more than half surviving for 10 years [6, 7]. Conventional medicine treatment (CMT) like conventional western medicine therapy is the standardized treatment for DCM.…”

Section: Introductionmentioning

confidence: 99%

Oral Chinese Herbal Medicine for Treatment of Dilated Cardiomyopathy: A Systematic Review and Meta‐Analysis

Zhu

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Dilated cardiomyopathy (DCM) is one of the main causes of heart failure and could increase death, hospitalization, and rehospitalization rate. The effect of conventional medicine treatment (CMT) is limited; meanwhile, the combination of CMT and Oral Chinese Herbal Medicine (OCHM) represents exciting adjunctive therapies. In this study, we ascertained the therapeutic effect of OCHM in combination with CMT for dilated cardiomyopathy by using meta-analysis methods for controlled clinical trials. We searched studies from five databases and extracted data from these studies. We also assessed the methodological quality of the included studies. We evaluated the following outcome measures to estimate the prognosis in patients with DCM: left ventricular ejection fraction (LVEF), left ventricular end-diastolic dimension (LVEDD), stroke volume (SV), brain natriuretic peptide (BNP), 6-minute walk test (6MWT), and overall efficacy. The result showed that OCHM combined with CMT for the improvement of therapeutic effect in DCM patients. However, the evidence remains weak due to the small sample size, high clinical heterogeneity, and poor methodological quality of the included trials. Further, large sample size and well-designed trials are needed.

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“…The prognosis is usually poor, but some patients do recover normal cardiac function. Studies in both adults and children have reported recovery of cardiac function in 21% to 37% of patients, as indicated by serial echocardiograms (3–5). Survival of adults with idiopathic DCM has improved in recent decades, with more than half surviving for 10 years (5,6).…”

Section: Introductionmentioning

confidence: 99%

“…Studies in both adults and children have reported recovery of cardiac function in 21% to 37% of patients, as indicated by serial echocardiograms (3–5). Survival of adults with idiopathic DCM has improved in recent decades, with more than half surviving for 10 years (5,6). Although risk factors for death or transplant in children with idiopathic DCM are well studied, predictors for normalization are largely unknown (7–10).…”

Section: Introductionmentioning

confidence: 99%

Recovery of Echocardiographic Function in Children With Idiopathic Dilated Cardiomyopathy

Everitt

Sleeper

Lü

et al. 2014

Journal of the American College of Cardiology

120

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Objectives To determine the incidence of and predictors for recovery of normal echocardiographic function among children with idiopathic dilated cardiomyopathy (DCM). Background Most children with idiopathic DCM have poor outcomes; however, some improve. Methods We studied children less than 18 years old in the Pediatric Cardiomyopathy Registry who had both depressed left ventricular (LV) function (fractional shortening [FS] or ejection fraction [EF] z-score <−2) and LV dilation (end-diastolic dimension [LVEDD] z-score >2) at diagnosis and who had at least one follow-up echocardiogram 30 days to 2 years from the initial echocardiogram. We estimated the cumulative incidence and predictors of normalization. Results Among 868 children who met inclusion criteria, 741 (85%) had both echocardiograms. At 2 years, 22% had recovered normal LV function and size; 51% had died or undergone heart transplant (median, 3.2 months), and 27% had persistently abnormal echocardiograms. Younger age (hazard ratio, 0.90; 95% CI, 0.86 to 0.95) and lower LVEDD z-score (0.75; 95% CI, 0.68 to 0.84) independently predicted normalization. Nine children (9%) with normal LV function and size within 2 years of diagnosis later underwent heart transplant or died. Conclusions Despite marked LV dilation and depressed function initially, children with idiopathic DCM can recover normal LV size and function, particularly those younger and with less LV dilation at diagnosis. Investigations related to predictors for recovery, such as gene associations, serum markers, and the impact of medical therapy or ventricular unloading with assist devices are important next steps. Longer follow-up after normalization is warranted as cardiac failure can recur. Clinical Trials Registration # NCT00005391

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Left Ventricular Reverse Remodeling in Long-Term (>12 Years) Survivors With Idiopathic Dilated Cardiomyopathy

Cited by 39 publications

References 22 publications

Myocardial remodelling and recovery in dilated cardiomyopathy

Myocardial remodelling and recovery in dilated cardiomyopathy

Oral Chinese Herbal Medicine for Treatment of Dilated Cardiomyopathy: A Systematic Review and Meta‐Analysis

Recovery of Echocardiographic Function in Children With Idiopathic Dilated Cardiomyopathy

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