Left ventricular twist in hypertrophic cardiomyopathy

Candan, Özkan; Geçmen, Çetin; Kalaycı, Arzu; Bayam, Emrah; Güner, Ahmet; Gündüz, Sabahattin; Çerşit, Sinan; Özkan, Mehmet

doi:10.1007/s00059-017-4633-7

Cited by 7 publications

(3 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Changes in LV rotation have been observed at the early phase of many cardiac diseases, and they even precede changes in longitudinal and circumferential strain (18). Aging, hypertension, hypertrophic cardiomyopathy and aortic stenosis are all characterized by increased apical rotation and delayed rotation with longer untwisting (18)(19)(20)(21)(22). Anthracycline treatment has induced a decline in both apical and basal rotation along with an overall twist becoming declined and delayed (23).…”

Section: Changes In Apical Strain In the Follow-up According To Brementioning

confidence: 99%

Left Ventricular Speckle Tracking Echocardiography Changes Among Early-stage Breast Cancer Patients Three Years After Radiotherapy

et al. 2019

View full text Add to dashboard Cite

Background/Aim: Chest radiotherapy (RT) doubles late cardiac mortality. This study aimed to evaluate the evolution of cardiac changes in speckle tracking echocardiography during a three-year follow-up. Materials and Methods: This prospective study included 81 chemotherapy-naïve early-stage breast cancer patients who were evaluated at baseline, immediately after RT and three years after RT. Sixty-one patients had left-sided (LSBC) and 20 right-sided breast cancer (RSBC). Results: Global longitudinal strain (GLS) declined from baseline-18.0±3.3% to-17.0±3.0% (p=0.015) at the three-year follow-up examination. A decline over 15% (GLS15) was observed in 19 (27%) patients. GLS15 was independently associated with aromatase inhibitor use (β=-1.977, p=0.001). In regional analysis, patients with LSBC had apical strain decline by 3.2±5.5% (p<0.001) and patients with RSBC showed basal rotation decline by 1.8˚ (-0.2˚, 3.8˚) (p=0.030). Conclusion: Even contemporary RT induced progressive global and regional decline in speckle tracking analysis. The regional changes complied with RT fields. Radiotherapy (RT) is an integral part of the treatment in half of cancer patients (1). Over 80% of early-stage breast cancer patients receive adjuvant RT, which reduces the local recurrence risk by half and, the late breast cancer-related mortality by a fifth. The overall survival of early-stage breast cancer patients at 5 years is 91% in Finland (www.cancerregistry.fi). However, RT induces adverse effects in healthy tissue, which may lead to late dysfunction in adjacent organs. The heart is an important organ at risk, especially in left-sided breast cancer (LSBC). Breast cancer RT increases cardiac mortality and morbidity almost twofold in long-term cohorts collected from patients treated with older RT techniques (2, 3). The modern RT treatment protocols have reduced cardiac radiation exposure. However, the clinical impact of the reduced cardiac dose will not be revealed until long-term data are available. In the meantime, early and mid-term cardiac changes are valuable in predicting later sequelae and to reveal the mechanism and time-course of RT-induced heart disease (RIDH). RIHD can manifest as coronary artery disease, valvular lesions, heart failure, pericardial changes or conduction abnormalities. These changes occur usually several years or decades after RT treatment (2-4). The early subclinical RTinduced cardiac changes precede the late manifestations. Perfusion defects and changes in strain and strain rate corresponding to the RT fields have been detected 0-6 months after RT with myocardial perfusion imaging and with echocardiography (5-7). After chemotherapy, an early change in global longitudinal strain (GLS) predicts later decline in left ventricular ejection fraction (LVEF), but the knowledge of post-RT strain evolution is sparse (8, 9). The aim of our study was to explore the evolution of early RT-induced changes in speckle tracking echocardiography (STE) in early-stage breast cancer patients within the first three years after ...

show abstract

Section: Changes In Apical Strain In the Follow-up According To Brementioning

confidence: 99%

Left Ventricular Speckle Tracking Echocardiography Changes Among Early-stage Breast Cancer Patients Three Years After Radiotherapy

et al. 2019

View full text Add to dashboard Cite

show abstract

“…We read with great interest the article by Candan and colleagues [1]. The authors have found an independent association of increased left ventricular twist and decreased global longitudinal strain (GLS) with the occurrence of nonsustained ventricular tachycardia (NSVT) during Holtermonitoring inpatients with hypertrophic cardiomyopathy (HCM).…”

Section: Speckle Tracking Imaging In Hypertrophic Cardiomyopathymentioning

confidence: 99%

Speckle tracking imaging in hypertrophic cardiomyopathy

Rigopoulos

Ali

Sakellaropoulos

et al. 2017

Herz

View full text Add to dashboard Cite

“…We are pleased with the authors' interest in our article titled "Left ventricular twist in hypertrophic cardiomyopathy: predictors of nonsustained ventricular tachycardia" published in Herz [1], and we would like to thank them for their contribution.…”

mentioning

confidence: 99%