Leftward shift in the acquisition of cocaine self-administration in isolation-reared rats: relationship to extracellular levels of dopamine, serotonin and glutamate in the nucleus accumbens and amygdala-striatal FOS expression

Howes, Simon R.; Dalley, Jeffrey W.; Morrison, Caroline H.; Robbins, Trevor W.; Everitt, Barry J.

doi:10.1007/s002130000451

Cited by 146 publications

(144 citation statements)

References 58 publications

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“…Moreover, the enhanced dopamine response to cocaine produced by PNS is similar to that reported in neonatal isolates (Kehoe et al, 1996;Kosten et al, 2004aKosten et al, , 2003Kosten et al, , 2005Kosten et al, , 2006; see also Howes et al, 2000 for similar results following juvenile isolation) or in rodents subjected to neonatal anoxia (Juarez et al, 2003) in response to other psychomotor stimulant drugs. Neonatal isolates also show a reduction in NAC serotonin (Kosten et al, 2004b) similar to that observed in the present study in PNS rats.…”

Section: Influence Of Pns On Neurochemical Responses To Cocainesupporting

confidence: 78%

Prenatal Stress Enhances Responsiveness to Cocaine

Kippin

Szumlinski

Kapasova

et al. 2007

Neuropsychopharmacol

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Early environmental events have profound influences on a wide range of adult behavior. In the current study, we assessed the influence of maternal stress during gestation on psychostimulant and neurochemical responsiveness to cocaine, cocaine self-administration, and reinstatement of cocaine-seeking in adult offspring. Pregnant, female Sprague-Dawley rats were subjected to either no treatment or to restraint stress three times per day for the last 7 days of gestation and cocaine-related behavior was assessed in offspring at 10 weeks of age. Relative to controls, a noncontingent cocaine injection elevated locomotor activity as well as nucleus accumbens levels of extracellular dopamine and glutamate to a greater extent in both cocaine-naïve and cocaine-experienced prenatal stress (PNS) rats and elevated prefrontal cortex dopamine in cocaine-experienced PNS rats. To assess the impact of PNS on cocaine addiction-related behavior, rats were trained to lever press for intravenous (i.v.) infusions of cocaine (0.25, 0.5, or 1 mg/kg/infusion), with each infusion paired with a light + tone-conditioned stimulus. Lever-pressing was extinguished and cocaine-seeking reinstated by re-exposure to the conditioned cues or by intraperitoneal cocaine-priming injections (5 or 10 mg/kg). PNS elevated active lever responding both during extinction and cocaine-primed reinstatement, but not during self-administration or conditioned-cued reinstatement. PNS also did not alter intake during self-administration. These findings demonstrate that PNS produces enduring nervous system alterations that increase the psychomotor stimulant, motivational, and neurochemical responsiveness to noncontingent cocaine. Thus, early environmental factors contribute to an individual's initial responsiveness to cocaine and propensity to relapse to cocaine-seeking.

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Section: Influence Of Pns On Neurochemical Responses To Cocainesupporting

confidence: 78%

Prenatal Stress Enhances Responsiveness to Cocaine

Kippin

Szumlinski

Kapasova

et al. 2007

Neuropsychopharmacol

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“…Furthermore, direct stimulation of USVs by injection of quinpirole into the shell of the nucleus accumbens is mediated in a complex triphasic way by both dopamine D2 and D3 receptors (Brudzynski et al, 2012). Social isolation (without neonatal PCP) has been shown to increase basal dopamine release in the nucleus accumbens and enhance release in response to amphetamine (Hall et al, 1998), cocaine (Howes et al, 2000) and emotional stimuli (Fulford and Marsden, 1998). Thus the increase in USVs seen in PCP/isolated rats might represent an enhanced response resulting from the priming of the dopaminergic mesolimbic system.…”

Section: Discussionmentioning

confidence: 99%

The dopamine D 3 -preferring D 2 /D 3 dopamine receptor partial agonist, cariprazine, reverses behavioural changes in a rat neurodevelopmental model for schizophrenia

Watson

King

Gyertyán

et al. 2016

European Neuropsychopharmacology

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. (2016) The dopamine D3-preferring D2/D3 dopamine receptor partial agonist, cariprazine, reverses behavioral changes in a rat neurodevelopmental model for schizophrenia. European Neuropsychopharmacology, 26 . pp. 208-224. ISSN 1873-7862 Access from the University of Nottingham repository: http://eprints.nottingham.ac.uk/34643/1/Fone%20cariprazine %20EurNeuropsych2016%20epub.pdf Copyright and reuse:The Nottingham ePrints service makes this work by researchers of the University of Nottingham available open access under the following conditions. This article is made available under the Creative Commons Attribution Non-commercial No Derivatives licence and may be reused according to the conditions of the licence. For more details see: http://creativecommons.org/licenses/by-nc-nd/2.5/ A note on versions:The version presented here may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the repository url above for details on accessing the published version and note that access may require a subscription.For more information, please contact eprints@nottingham.ac.ukThe dopamine D3-preferring D2/D3 dopamine receptor partial agonist, cariprazine, reverses behavioral changes in a rat neurodevelopmental model for schizophrenia Current antipsychotic medication is largely ineffective against the negative and cognitive symptoms of schizophrenia. One promising therapeutic development is to design new molecules that balance actions on dopamine D2 and D3 receptors to maximise benefits and limit adverse effects. This study used two rodent paradigms to investigate the action of the dopamine D3-preferring D3/D2 receptor partial agonist cariprazine. In adult male rats, cariprazine (0.03-0.3mg/kg i.p.), and the atypical antipsychotic aripiprazole (1-3mg/kg i.p.) caused dose-dependent reversal of a delay-induced impairment in novel object recognition (NOR). Treating neonatal rat pups with phencyclidine (PCP) and subsequent social isolation produced a syndrome of behavioral alterations in adulthood including hyperactivity in a novel arena, deficits in NOR and fear motivated learning and memory, and a reduction and change in pattern of social interaction accompanied by increased ultrasonic vocalisations (USVs).Acute administration of cariprazine (0.1 and 0.3mg/kg) and aripiprazole (3mg/kg) to resultant adult rats reduced neonatal PCP-social isolation induced locomotor hyperactivity and reversed NOR deficits. Cariprazine (0.3mg/kg) caused a limited reversal of the social interaction deficit but neither drug affected the change in USVs or the deficit in fear motivated learning and memory. Results suggest that in the behavioral tests investigated cariprazine is at least as effective as aripiprazole and in some paradigms it showed additional beneficial features further supporting the advantage of combined dopamine D3/D2 receptor targeting. These findings support recent clinical studies demonstrating the efficacy of cariprazine in tr...

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“…infusion) is used (Bardo et al, 2001). IC rats also display a leftward shift in the cocaine dose response curve compared with SC rats (Howes et al, 2000), indicating that isolation housing enhances sensitivity to stimulant reinforcement compared with social housing. However, the presence of novel objects also plays a role, as the behavioral responses to stimulants, opiates, and alcohol differ between SC and EC animals (Bardo et al, 2001;Green et al, 2003;Coolon and Cain, 2009;El Rawas et al, 2009;de Carvalho et al, 2010).…”

Section: Psychosocial Influences and Abused Drugsmentioning

confidence: 95%

“…In contrast, IC rats have increased amphetamine-stimulated levels of extracellular dopamine in striatum and the nucleus accumbens using in vivo microdialysis compared with SC rats (Jones et al, 1992), although this effect is not obtained under chloral hydrate anesthesia . IC rats also show greater cocaine-stimulated release of accumbal dopamine and greater alterations in the immediate-early genes c-fos and zif-268 in striatum and the central nucleus of the amygdala and, in some cases, in the nucleus accumbens and frontal cortex (Howes et al, 2000;Solinas et al, 2009;Thiel et al, 2010). Housing-induced differences in neurochemical response to stimulant drugs do not likely reflect pharmacokinetic changes, as brain levels of [ 3 H]amphetamine are similar in IC and EC rats after systemic injection .…”

Section: Psychosocial Influences and Abused Drugsmentioning

confidence: 96%

Individual Differences and Social Influences on the Neurobehavioral Pharmacology of Abused Drugs

2013

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Leftward shift in the acquisition of cocaine self-administration in isolation-reared rats: relationship to extracellular levels of dopamine, serotonin and glutamate in the nucleus accumbens and amygdala-striatal FOS expression

Abstract: These data are consistent with the hypothesis that isolation rearing produces enduring changes in the sensitivity of dopamine-mediated functions in amygdala-striatal circuitry that may be directly related to the altered reinforcing properties of cocaine and other psychomotor stimulants.

Cited by 146 publications

References 58 publications

Prenatal Stress Enhances Responsiveness to Cocaine

Prenatal Stress Enhances Responsiveness to Cocaine

The dopamine D 3 -preferring D 2 /D 3 dopamine receptor partial agonist, cariprazine, reverses behavioural changes in a rat neurodevelopmental model for schizophrenia

Individual Differences and Social Influences on the Neurobehavioral Pharmacology of Abused Drugs

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