Leg fat mass as measured by dual X‐ray absorptiometry (DXA) impacts insulin resistance differently in obese women versus men

Aasen, Gunnar; Fagertun, Hans; Tonstad, Serena; Halse, Johan

doi:10.1080/00365510802464641

Cited by 21 publications

(19 citation statements)

References 38 publications

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“…It has been reported that leg/total and leg/trunk ratios of regional fat have a favorable influence on serum lipids in adult patients with coronary atherosclerosis, 25 as well as in obese women. 26 In the present study, the trunk-to-appendicular fat ratio had an unfavorable influence on blood pressure in a general population of children, while the appendicular-totrunk fat ratio had a favorable influence.…”

Section: Discussionsupporting

confidence: 39%

Increased Ratio of Trunk to Appendicular Fat and Increased Blood Pressure

Kouda

Nakamura

Fujita

et al. 2012

Circ J

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Section: Discussionsupporting

confidence: 39%

Increased Ratio of Trunk to Appendicular Fat and Increased Blood Pressure

Kouda

Nakamura

Fujita

et al. 2012

Circ J

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“…40,41 The determination of trFM/lFM ratio is a validated marker of insulin resistance. 23,24 Furthermore, evaluation of trFM/ lFM ratio takes into account the subcutaneous fat and Bariatric surgery and cardiometabolic risk factors C Lubrano et al characterizes a more metabolically benign phenotype of obesity. 42 It is noteworthy that BIBP patients showed more pronounced reduction of trFM and of trFM/lFM than LAGB at all time intervals.…”

Section: Discussionmentioning

confidence: 99%

“…Before each scanning session, the Hologic QDR 4500W was calibrated according to the standard procedures recommended by the manufacturer. [19][20][21][22][23][24] BP was measured by a mercury sphygmomanometer (Riva-Rocci System, ERKA, Chemnitz, Germany).…”

Section: Assessmentmentioning

confidence: 99%

Metabolic or bariatric surgery? Long-term effects of malabsorptive vs restrictive bariatric techniques on body composition and cardiometabolic risk factors

et al. 2010

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Background: Obesity is an increasing health problem and surgery seems to be the only treatment effective in achieving weight loss without relapse. Among bariatric techniques, many differences exist in terms of weight loss and resolution of comorbidities. Up to now, there are no prospective studies comparing long-term effects of malabsorptive vs restrictive techniques. Objective: In this study, cardiometabolic risk factors and body composition changes after malabsorptive biliointestinal bypass (BIBP) and restrictive laparoscopic adjustable gastric banding (LAGB) were compared during a 4-year follow-up. Design: Prospective, case-control and cohort study. Patients: In all, 80 obese subjects, matched for weight and age. Altogether, 40 patients underwent BIBP and 40 underwent LAGB. Measurements: Weight, body composition, fasting and post-loading plasma glucose and insulin, homeostatic model assessment index (HOMA-I), lipid profile, blood pressure (BP), erythrocyte sedimentation rate and fibrinogen were monitored at baseline, 12 and 48 months. Results: At 12 months after surgery, a significant reduction in body mass index, total fat mass (FM), trunk FM (trFM), trFM/legs FM (lFM) ratio (trFM/lFM), triglycerides, BP and inflammation markers was observed in both groups. BIBP patients showed a significant reduction in total cholesterol (Tot-C), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C), whereas the LAGB group showed a significant increase of HDL-C. A further improvement of all the parameters evaluated was seen in the BIBP group at 48 months after surgery. Conclusions: Both bariatric procedures exerted positive effects on cardiometabolic risk factors and on weight loss in the population studied, but on the long-term period, HOMA-I, Tot-C/HDL-C ratio and body composition improvements were more evident after BIBP. We conclude that malabsorptive BIBP seems to be more effective than LAGB in treating visceral obesity and its metabolic complications

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“…These associations have been observed in black, white, and Japanese populations. 8,22,[24][25][26][27] To our knowledge, no studies have evaluated the association of hip circumference, independent of waist circumference or BMI, with cardiovascular risk factors in a Chinese population. It is well established that adiposity is associated with metabolic risk.…”

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confidence: 99%

Hip Circumference and Incident Metabolic Risk Factors in Chinese Men and Women: The People's Republic of China Study

Katz

Stevens

Truesdale

et al. 2011

Metabolic Syndrome and Related Disorders

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Background: The associations between adiposity and metabolic risk factors have been suggested to vary across ethnicities. Studies in Caucasians have shown that after adjusting for waist circumference and body mass index (BMI), a larger hip circumference may be protective for metabolic risk factors. To our knowledge, these associations have never been examined in a Chinese population. Methods: Baseline (1987)(1988) and follow-up (1993-1994) data were from the People's Republic of China Study (n ¼ 1,144 men, n ¼ 1,776 women). Logistic models were stratified by sex and adjusted for age, smoking, center, and education. Incidence differences (ID) comparing the sex specific 85 th percentile to the 15 th percentile of hip circumference were computed for elevated blood pressure, blood glucose and triglycerides, low high-density lipoprotein cholesterol (HDL-C), and multiple metabolic abnormalities (three or more of the aforementioned). Results: In models adjusted for waist circumference and BMI, the ID [95% confidence interval (CI)] per 1,000 persons associated with a 12-cm larger hip were À132 (À237, À26) for low HDL-C; À85 (À138, À31) for elevated triglycerides; and À49 (À83, À4) for multiple metabolic abnormalities. In males, a larger hip circumference was not associated with a reduction of incident risk factors, although the ID tended to be negative. Conclusions: In Chinese women, greater mass in the lower trunk region was inversely associated with incident high triglycerides, low HDL-C, and multiple metabolic abnormalities when adjusted for general and central adiposity. This association was not detected in men. Additional research is needed to better understand the mechanisms by which fat at different depots results in differential risk.

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Leg fat mass as measured by dual X‐ray absorptiometry (DXA) impacts insulin resistance differently in obese women versus men

Abstract: Leg FM has a favourable influence on insulin resistance and dyslipidaemia in obese women, but not demonstrated in this cohort of obese men.

Cited by 21 publications

References 38 publications

Increased Ratio of Trunk to Appendicular Fat and Increased Blood Pressure

Increased Ratio of Trunk to Appendicular Fat and Increased Blood Pressure

Metabolic or bariatric surgery? Long-term effects of malabsorptive vs restrictive bariatric techniques on body composition and cardiometabolic risk factors

Hip Circumference and Incident Metabolic Risk Factors in Chinese Men and Women: The People's Republic of China Study

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