In the context of the digital age, organ transplantation, as a life-saving technology, has become increasingly prominent in its information security. This paper aims to explore and construct a legal framework for organ transplant information security that meets the requirements of the digital age. First, the article outlines the legal background of organ transplantation and its new challenges in the digital age, emphasizing the centrality of information security in the organ transplantation process. The article then elaborates on the legal definitions and classifications of organs and discusses how digital technologies are changing these definitions and classifications. In the same way, the study of how people think about organ donation and transplantation used non-parametric tests, analysis of variance, and logistic regression to determine how people think about these things differently in different groups. Dichotomous logistic regression models were also created. This paper examines the current legal frameworks that protect organ transplant information in the digital age. The focus is on how biotechnology is linked to data privacy, security measures, and ethical concerns. This shows the importance of a complete regulatory framework to protect individuals' health information about organ transplants. This paper's research goal is to make a stronger legal guarantee for organ transplant information security. This will help organ transplantation technology grow healthily, protect the rights and interests of donors and recipients, and keep people's sense of dignity.