Leishmanicidal Activity of Biogenic Fe3O4 Nanoparticles

Khatami, Mehrdad; Alijani, Hajar Q.; Sharifi, Iraj; Sharifi, Farshad; Pourseyedi, Shahram; Kharazi, Sam; Nobre, Marcos Augusto Lima; Khatami, Manouchehr

doi:10.3390/scipharm85040036

Cited by 65 publications

(29 citation statements)

References 48 publications

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“…Henceforth, considerable research work has been done to develop MNPs for Leishmania treatment. Different MNPs have been utilized in different in vitro studies for the cytotoxic assessment against leishmanial parasites . However, biogenic IONPs have been poorly investigated for cytotoxicity potential against L .…”

Section: Resultsmentioning

confidence: 99%

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Biofabrication of iron oxide nanoparticles by leaf extract of Rhamnus virgata: Characterization and evaluation of cytotoxic, antimicrobial and antioxidant potentials

Abbasi

Iqbal

Mahmood

et al. 2019

Applied Organom Chemis

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In the present study, plant‐mediated synthesis of iron oxide nanoparticles (IONPs) using leaves extract of Rhamnus virgata (Roxb.) as a potential stabilizing, reducing and chelating agent is reported. The biogenic IONPs are extensively characterized for their physical and biological properties. The morphology, structure and physicochemical properties of biogenic IONPs were characterized using ultraviolet spectroscopy, X‐ray diffraction, Fourier transform‐infrared analysis, scanning electron microscopy, energy‐dispersive spectroscopy, transmission electron microscopy, Raman spectroscopy and dynamic light scattering. The Scherrer equation deduced a mean crystallite size of ~20 nm for IONPs. Detailed in vitro biological activities revealed significant therapeutic potentials for IONPs. Potential antibacterial and antifungal activities are reported for IONPs. Bioinspired IONPs have shown potential results against HepG2 cells (IC50: 13.47 μg/ml). Dose‐dependent cytotoxicity assays were revealed against Leishmania tropica (KMH23) promastigotes (IC50: 8.08 μg/ml) and amastigotes (IC50: 20.82 μg/ml) using different concentrations of IONPs (1–200 μg/ml). The cytotoxic activity was also studied using brine shrimps, and their IC50 value was calculated as 32.41 μg/ml. Significant antioxidant [TAC (51.4%), DPPH (79.4%) and total reducing power (62%)], protein kinase and alpha amylase inhibition assays were revealed. The biocompatibility assays using red blood cells (> 200 μg/ml) and macrophages (> 200 μg/ml) confirmed the biosafe nature of IONPs. In conclusion, bioinspired IONPs have shown potential biological applications and should be subjected to further research work to develop their nano‐pharmacological relevance in biomedical applications.

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Section: Resultsmentioning

confidence: 99%

“…Different MNPs have been utilized in different in vitro studies for the cytotoxic assessment against leishmanial parasites. [34,56] However, biogenic IONPs have been poorly investigated for cytotoxicity potential against L. tropica (KMH 23 ).…”

Section: Antileishmanial Activitymentioning

confidence: 99%

Biofabrication of iron oxide nanoparticles by leaf extract of Rhamnus virgata: Characterization and evaluation of cytotoxic, antimicrobial and antioxidant potentials

Abbasi

Iqbal

Mahmood

et al. 2019

Applied Organom Chemis

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“…A study was conducted for the treatment of visceral leishmaniasis with iron oxide (Fe 3 O 4 ) nanoparticles coated with glycine (peptide), which encapsulated the AmB drug. A 10-15 nm nanoparticle size was used, which enabled the controlled release of AmB, reducing the parasitic content in the spleen of treated subjects [94]. Glycine-coated nanoparticles could be employed further in leishmanial treatments.…”

Section: Metallic Nanoparticlesmentioning

confidence: 99%

Applications of Nanomaterials in Leishmaniasis: A Focus on Recent Advances and Challenges

et al. 2019

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Leishmaniasis is a widely distributed protozoan vector-born disease affecting almost 350 million people. Initially, chemotherapeutic drugs were employed for leishmania treatment but they had toxic side effects. Various nanotechnology-based techniques and products have emerged as anti-leishmanial drugs, including liposomes, lipid nano-capsules, metal and metallic oxide nanoparticles, polymeric nanoparticles, nanotubes and nanovaccines, due to their unique properties, such as bioavailability, lowered toxicity, targeted drug delivery, and biodegradability. Many new studies have emerged with nanoparticles serving as promising therapeutic agent for anti-leishmanial disease treatment. Liposomal Amphotericin B (AmB) is one of the successful nano-based drugs with high efficacy and negligible toxicity. A new nanovaccine concept has been studied as a carrier for targeted delivery. This review discusses different nanotechnology-based techniques, materials, and their efficacies in leishmaniasis treatment and their futuristic improvements.

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“…In global standard norms, materials or particles that in at least one dimension have a length of 1 to 100 nanometers (nm) are termed nanoparticles (nanomaterials) [1,2]. Nanoparticles (NPs) are aggregates of between a few and many millions of atoms.…”

Section: Introductionmentioning

confidence: 99%

Core@shell Nanoparticles: Greener Synthesis Using Natural Plant Products

et al. 2018

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Featured Application: Greener synthesis and applications of Core-shell nanoparticles.Abstract: Among an array of hybrid nanoparticles, core-shell nanoparticles comprise of two or more materials, such as metals and biomolecules, wherein one of them forms the core at the center, while the other material/materials that were located around the central core develops a shell. Core-shell nanostructures are useful entities with high thermal and chemical stability, lower toxicity, greater solubility, and higher permeability to specific target cells. Plant or natural products-mediated synthesis of nanostructures refers to the use of plants or its extracts for the synthesis of nanostructures, an emerging field of sustainable nanotechnology. Various physiochemical and greener methods have been advanced for the synthesis of nanostructures, in contrast to conventional approaches that require the use of synthetic compounds for the assembly of nanostructures. Although several biological resources have been exploited for the synthesis of core-shell nanoparticles, but plant-based materials appear to be the ideal candidates for large-scale green synthesis of core-shell nanoparticles. This review summarizes the known strategies for the greener production of core-shell nanoparticles using plants extract or their derivatives and highlights their salient attributes, such as low costs, the lack of dependence on the use of any toxic materials, and the environmental friendliness for the sustainable assembly of stabile nanostructures.

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Leishmanicidal Activity of Biogenic Fe3O4 Nanoparticles

Cited by 65 publications

References 48 publications

Biofabrication of iron oxide nanoparticles by leaf extract of Rhamnus virgata: Characterization and evaluation of cytotoxic, antimicrobial and antioxidant potentials

Biofabrication of iron oxide nanoparticles by leaf extract of Rhamnus virgata: Characterization and evaluation of cytotoxic, antimicrobial and antioxidant potentials

Applications of Nanomaterials in Leishmaniasis: A Focus on Recent Advances and Challenges

Core@shell Nanoparticles: Greener Synthesis Using Natural Plant Products

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