Leishmaniose tegumentar em paciente com espondilite anquilosante utilizando adalimumabe

Gomes, Kirla Wagner Poti; Benevides, André Nunes; Vieira, Francisco José Fernandes; Burlamaqui, Maggy Poti de Morais; Vieira, Marcos de Almeida e Pontes; Fontenelle, Lysiane Maria Adeodato Ramos

doi:10.1590/s0482-50042012000300014

Cited by 10 publications

(3 citation statements)

References 10 publications

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“…Since then, 37 cases (including ours) of anti-TNF-induced leishmaniasis have been reported (online supplementary table 1, see www.karger.com/doi/10.1159/000370238) [15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45]. All patients were living in or had travelled to leishmaniasis-endemic areas.…”

Section: Discussionmentioning

confidence: 99%

Anti-Tumour Necrosis Factor-Induced Visceral and Cutaneous Leishmaniasis: Case Report and Review of the Literature

et al. 2015

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Background: Leishmaniasis is a chronic protozoan disease in which organisms are found within phagolysosomes of the mononuclear phagocyte system. There are three major forms: cutaneous, mucocutaneous and visceral. We report the first case of visceral leishmaniasis with cutaneous involvement in a patient with rheumatoid arthritis treated with the anti-tumour necrosis factor (anti-TNF) adalimumab. Objective: To highlight cutaneous leishmaniasis as the first indicator of a kala-azar disease in a patient treated with anti-TNF and to review the literature on leishmaniasis in the context of anti-TNF therapy. Case Report: A 59-year-old woman presented with a crusted plaque on the right elbow 34 months after the initiation of adalimumab. A cutaneous biopsy showed intracellular amastigotes. No Leishmania parasites were observed in a bone marrow aspirate, but laboratory tests showed anaemia and impaired liver function, abdominal ultrasonography showed hepatomegaly, and ELISA serology was strongly positive for Leishmania antibodies in serum and urine. Adalimumab was withdrawn and treatment combining intralesional pentavalent antimonials and liposomal amphotericin was started. Eight weeks later, the leishmaniasis had resolved. Conclusion: A skin biopsy disclosing leishmaniasis should prompt tests to rule out visceral leishmaniasis, especially in an area such as the Mediterranean where the prevalence of latent Leishmania infection is high.

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Section: Discussionmentioning

confidence: 99%

Anti-Tumour Necrosis Factor-Induced Visceral and Cutaneous Leishmaniasis: Case Report and Review of the Literature

et al. 2015

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“…Cases of cutaneous leishmaniasis in patients taking TNF-α are poorly described in the literature. 26 The use of copaiba oil (Copaifera sp.) has also been suggested as alternative medicine in treating rheumatoid arthritis, with doses that are still under investigation in the scientific field.…”

Section: Dermatological Therapeutic Effects Of Copaiba Oil-resinmentioning

confidence: 99%

Minireview about Medicinal Copaiba Oil in the Treatment of Skin Diseases

Campanholi¹,

Júnior²,

Braga³

et al. 2022

J Dermatol & Skin Sci

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The therapeutic benefits of copaiba oil-resin have encouraged its use in developing dermatological emulsions. Here, the anti-inflammatory, healing, antimicrobial, analgesic, and permeation-promoting properties of this medicinal oil are shown by reviewing articles from 2005 to 2021. Their properties encourage research to develop an herbal medicinal effective in treating skin diseases and cutaneous leishmaniasis.

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“…A espécie Lutzomyia longipalpis tem sido apontada como a principal responsável pela transmissão de L. infantum no Brasil 5 . Após inoculação no hospedeiro vertebrado, os parasitos apresentam tropismo por células do sistema mononuclear fagocitário (SFM), configurando infecções intracelulares obrigatórias 6 .…”

Section: Introductionunclassified

Assentamentos De Reforma Agrária E a Vigilância Em Saúde Para Leishmaniose Visceral Na Região De Presidente Prudente-Sp, Brasil

et al. 2018

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A Leishmaniose Visceral (LV) possui interdependência com regiões de florestas remanescentes modificadas, e os espaços rurais tendem a armazenar vetores e reservatórios. Esse estudo objetivou dimensionar diferentes situações de risco epidemiológico conforme a classificação epidemiológica e o favorecimento da ocorrência de Leishmaniose Visceral em municípios que abrigam assentamentos de reforma agrária, pertencentes à Região de Saúde de Presidente Prudente-SP. As regiões de estudo foram classificadas segundo a estrutura do serviço de zoonoses e situação epidemiológica, aplicando-se análise espacial e tratamento cartográfico das informações. De 45 municípios, 19 (42,2%) abrigam um total de 121 assentamentos, enfrentando diferentes cenários. Houve estreita relação quanto à disponibilização e atuação da equipe de zoonoses e a situação da Leishmaniose Visceral, especialmente nos municípios de estudo silenciosos (receptivos ou não) e em investigação. Os resultados contribuem para a vigilância em saúde, apoio a decisão em áreas prioritárias e fortalecimento do Sistema Único de Saúde (SUS).

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Leishmaniose tegumentar em paciente com espondilite anquilosante utilizando adalimumabe

Cited by 10 publications

References 10 publications

Anti-Tumour Necrosis Factor-Induced Visceral and Cutaneous Leishmaniasis: Case Report and Review of the Literature

Anti-Tumour Necrosis Factor-Induced Visceral and Cutaneous Leishmaniasis: Case Report and Review of the Literature

Minireview about Medicinal Copaiba Oil in the Treatment of Skin Diseases

Assentamentos De Reforma Agrária E a Vigilância Em Saúde Para Leishmaniose Visceral Na Região De Presidente Prudente-Sp, Brasil

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