Leisure Time Physical Activity and Mortality

Arem, Hannah; Moore, Stephen; Patel, Alpa V.; Hartge, Patricia; González, Amy Berrington de; Visvanathan, Kala; Campbell, Peter T.; Freedman, M.; Weiderpass, Elisabete; Adami, Hans Olov; Linet, Martha S.; Lee, I. Min; Matthews, Charles E.

doi:10.1001/jamainternmed.2015.0533

Cited by 1,184 publications

(592 citation statements)

References 49 publications

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“…Physical inactivity is a well‐known risk factor for cardiovascular disease (CVD)1, 2 and premature mortality from CVD 2, 3, 4. One explanation for these findings is thought to be because of beneficial effects of physical activity (PA) on endothelial function and the relatively less well‐studied biomarkers of atherosclerosis 5, 6, 7, 8, 9, 10, 11, 12.…”

Section: Introductionmentioning

confidence: 99%

Physical Activity, Sedentary Time, and Cardiovascular Disease Biomarkers at Age 60 to 64 Years

Elhakeem

Cooper

Whincup

et al. 2018

JAHA

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BackgroundWe examined associations of objectively measured physical activity (PA) and sedentary time with cardiovascular disease biomarkers at age 60 to 64 years. This included investigation of sex differences and the extent to which associations may be mediated by adiposity.Methods and ResultsParticipants were 795 men and 827 women aged 60 to 64 years from the Medical Research Council National Survey of Health and Development. Combined heart rate and movement sensors worn for 5 consecutive days were used to derive overall PA energy expenditure, kJ/kg per day) and time spent sedentary (<1.5 metabolic equivalent of tasks), in light PA (1.5–3 metabolic equivalent of tasks) and moderate‐to‐vigorous intensity PA (>3 metabolic equivalent of tasks). Linear regression models were used to relate each PA parameter to inflammatory (C‐reactive protein, interleukin‐6), endothelial (tissue‐plasminogen activator, E‐selectin) and adipokine (leptin, adiponectin) markers extracted from fasting blood samples. Greater time in light PA and moderate‐to‐vigorous intensity PA and less sedentary time were associated with more favorable biomarker levels. For C‐reactive protein, interleukin‐6, and leptin, these differences were greater among women than men. For example, % differences (95% confidence intervals) in leptin for men and women per SD increases in sedentary time: 7.9 (2.7, 13.0) and 20.6 (15.3, 25.8); moderate‐to‐vigorous intensity PA: −3.8 (−8.9, 12.7) and −17.7 (−23.1, −12.4), moderate‐to‐vigorous intensity PA: −12.9 (−17.9, −8.0) and −18.3 (−23.4, −13.1). Fat mass mediated a greater proportion of these associations in women than men.ConclusionsGreater light PA and moderate‐to‐vigorous intensity PA and less sedentary time in early old age were associated with more favorable cardiovascular biomarker profiles. Fat mass partially mediated these associations but more strongly in women than men, which explained sex differences.

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Section: Introductionmentioning

confidence: 99%

Physical Activity, Sedentary Time, and Cardiovascular Disease Biomarkers at Age 60 to 64 Years

Elhakeem

Cooper

Whincup

et al. 2018

JAHA

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“…Estudios recientes en otros países han señalado la relación positiva entre AF y salud para intervalos de edad semejantes (Gebel et al, 2015;Mesters et al, 2014). Considerando otros segmentos de edad, trabajos como los de Beyer et al (2015), Campos et al (2014), Arem (2015) o Rosenkranz et al (2013) entre otros han contrastado la relación positiva entre calidad de vida y salud autopercibida con la práctica de AF. Todo ello hace hincapié en la importancia de la AF para lograr un envejecimiento saludable.…”

Section: Introductionunclassified

Actividad física y salud autopercibida en personas mayores de 50 años / Physical Activity and Self-Perceived Health among People Aged 50 and Over

Lera‐López¹,

Irisarri²,

Ollo‐López³

et al. 2017

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AGRADECIMIENTOSEste estudio se ha desarrollado en el marco del proyecto de investigación "Actividad física y deportiva y su impacto en la salud y bienestar del ciudadano: Implicaciones económicas (186/UPB10/12), financiado por el Consejo Superior de Deportes (España). Código UNESCO / UNESCO RESUMENEl propósito del estudio es analizar los posibles efectos de la actividad física sobre la salud autopercibida. Para ello, se encuestó a 765 personas entre 50-70 años durante 2012 en España. Se utilizó el cuestionario internacional de actividad física (IPAQ) para estimar el equivalente metabólico de la tarea (MET) total y en cuatro ámbitos: trabajo, ocio, hogar y desplazamientos. La salud autopercibida se obtuvo de la escala visual analógica del EQ-5D-5L.

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“…For other cancers, the association is less clear 1, 2. An inverse association is also observed between physical activity and cancer mortality, for total cancer 3, 4, 5, 6, 7, 8, 9 and cancer‐specific for colon, liver, and lung cancer 3, 6, 9, 10. Whether prediagnostic physical activity influences cancer survival in cancer patients is a question given less attention.…”

Section: Introductionmentioning

confidence: 99%

Measured cardiorespiratory fitness and self‐reported physical activity: associations with cancer risk and death in a long‐term prospective cohort study

et al. 2016

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Physical activity is inversely associated with risk of some cancers. The relation with cancer‐specific death remains uncertain. Mainly, studies on relationships between physical activity and cancer are based on self‐reported physical activity (SPA). Hereby, we examined whether measured cardiorespiratory fitness (CRF) is associated with cancer risk, mortality, and case fatality. We also describe relationships between SPA and these outcomes, and between CRF and SPA. A cohort of 1997 healthy Norwegian men, aged 40–59 years at inclusion in 1972–75, was followed throughout 2012. At baseline, CRF was objectively measured. SPA (leisure time and occupational) was obtained through a questionnaire. Relationships between CRF or SPA, and the outcomes were estimated using Cox regression, adjusted for age, body mass index (BMI), and smoking. Pearson correlation coefficients evaluated agreements between CRF and SPA. During follow‐up, 758 men were diagnosed with cancer and 433 cancer deaths occurred. Analyses revealed lower cancer risk (Hazard ratio [HR] 0.85, 95% confidence intervals [CI]: 0.68–1.00), mortality (HR 0.68, 95% CI: 0.53–0.88), and case fatality (HR 0.74, 95% CI: 0.57–0.96), in men with high CRF compared to low CRF. Light leisure time SPA was associated with lower cancer risk (HR 0.70, 95% CI: 0.56–0.86) and mortality (HR 0.64 95% CI: 0.49–0.83), whereas strenuous occupational SPA was associated with higher risks (HR 1.42, 95% CI: 1.13–1.78 and HR 1.45, 95% CI: 1.09–1.93). Correlations between CRF and SPA were 0.351 (P < 0.001) and −0.106 (P < 0.001) for leisure time and occupational SPA, respectively. A high midlife CRF may be beneficial for cancer risk, cancer mortality, and case fatality.

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Leisure Time Physical Activity and Mortality

Cited by 1,184 publications

References 49 publications

Physical Activity, Sedentary Time, and Cardiovascular Disease Biomarkers at Age 60 to 64 Years

Physical Activity, Sedentary Time, and Cardiovascular Disease Biomarkers at Age 60 to 64 Years

Actividad física y salud autopercibida en personas mayores de 50 años / Physical Activity and Self-Perceived Health among People Aged 50 and Over

Measured cardiorespiratory fitness and self‐reported physical activity: associations with cancer risk and death in a long‐term prospective cohort study

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