Lemairones A and B: Two new antibacterial tetraflavonoids from the leaves of Zanthoxylum lemairei (Rutaceae)

Bitchagno, Gabin Thierry M.; Tankeo, Simplice B.; Tsopmo, Apollinaire; Mpetga, James D. Simo; Tchinda, Alembert T.; Fobofou, Serge Alain Tanemossu; Wessjohann, Ludger A.; Kuete, Victor; Tane, Pierre

doi:10.1016/j.phytol.2015.08.012

Cited by 25 publications

(10 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…aureus with MIC value of 7.3 μg/ml (Oh et al, ). Recently, Bitchagno et al () found that the tetraflavonoids ( 166 , 167 ) without OH on the C ring were moderate activity against E . coli .…”

Section: Structure–activity Relationshipmentioning

confidence: 99%

See 1 more Smart Citation

Antibacterial activity of flavonoids and their structure–activity relationship: An update review

Farhadi

Khameneh

Iranshahi

et al. 2018

Phytotherapy Research

487

305

View full text Add to dashboard Cite

Based on World Health Organization reports, resistance of bacteria to well-known antibiotics is a major global health challenge now and in the future. Different strategies have been proposed to tackle this problem including inhibition of multidrug resistance pumps and biofilm formation in bacteria and development of new antibiotics with novel mechanism of action. Flavonoids are a large class of natural compounds, have been extensively studied for their antibacterial activity, and more than 150 articles have been published on this topic since 2005. Over the past decade, some promising results were obtained with the antibacterial activity of flavonoids. In some cases, flavonoids (especially chalcones) showed up to sixfold stronger antibacterial activities than standard drugs in the market. Some synthetic derivatives of flavonoids also exhibited remarkable antibacterial activities with 20-to 80-fold more potent activity than the standard drug against multidrug-resistant Gram-negative and Gram-positive bacteria (including Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus). This review summarizes the ever changing information on antibacterial activity of flavonoids since 2005, with a special focus on the structure-activity relationship and mechanisms of actions of this broad class of natural compounds.

show abstract

Section: Structure–activity Relationshipmentioning

confidence: 99%

“…Also, sophoraflavanone G (83) with isogeranyl at C-8 and OH at 3, 2′, and 4′ on the A and B rings was active against S. aureus with MIC value of 7.3 μg/ml (Oh et al, 2011). Recently, Bitchagno et al (2015) found that the tetraflavonoids (166,167) without OH on the C ring were moderate activity against E. coli.…”

Section: Flavanes and Flavanolsmentioning

confidence: 99%

Antibacterial activity of flavonoids and their structure–activity relationship: An update review

Farhadi

Khameneh

Iranshahi

et al. 2018

Phytotherapy Research

487

305

View full text Add to dashboard Cite

show abstract

“…Apart from alkaloids, other antimicrobial compounds isolated from different Z. species include lignans (e.g., sesamin and syringaresinol) ( Rahman et al, 2008 ), tetraflavonoids (e.g., lemairones A and B) ( Bitchagno et al, 2015 ), and phytosterol (e.g., stigmasterol) ( Kaigongi et al, 2020 ). Lemairones A and B from Z. lemairei leaves moderately inhibited multidrug-resistant bacteria, K pneumoniae KP55 and E. coli AG100 with MIC values of 128 mg/ ml and 64 mg/ ml, respectively against E. coli AG100, and MIC value of 128 mg/ ml against K. pneumoniae KP55 ( Bitchagno et al, 2015 ). Furthermore, a polymeric procyanidin from Z. bungeanum fruit exhibited cytotoxicity against drug resistant strains of S. aureus with an MIC value of 128 μg/ ml; the compound acted by inhibiting β-lactamase activity and by inducing cell wall damage ( Kusuda et al, 2006 ).…”

Section: Zanthoxylum Species As Potential Sources Of Antimicrobial Agentsmentioning

confidence: 99%

Zanthoxylum Species: A Review of Traditional Uses, Phytochemistry and Pharmacology in Relation to Cancer, Infectious Diseases and Sickle Cell Anemia

et al. 2021

View full text Add to dashboard Cite

The health benefits and toxicity of plant products are largely dependent on their secondary metabolite contents. These compounds are biosynthesized by plants as protection mechanisms against environmental factors and infectious agents. This review discusses the traditional uses, phytochemical constituents and health benefits of plant species in genus Zanthoxylum with a focus on cancer, microbial and parasitic infections, and sickle cell disease as reported in articles published from 1970 to 2021 in peer-reviewed journals and indexed in major scientific databases. Generally, Z. species are widely distributed in Asia, America and Africa, where they are used as food and for disease treatment. Several compounds belonging to alkaloids, flavonoids, terpenoids, and lignans, among others have been isolated from Z. species. This review discusses the biological activities reported for the plant species and their phytochemicals, including anticancer, antibacterial, antifungal, antiviral, anti-trypanosomal, antimalarial and anti-sickling properties. The safety profiles and suggestions for conservation of the Z. species were also discussed. Taken together, this review demonstrates that Z. species are rich in a wide range of bioactive phytochemicals with multiple health benefits, but more research is needed towards their practical application in the development of functional foods, nutraceuticals and lead compounds for new drugs.

show abstract

“…As any other organisms on Earth, plants are said to possess multi-functional properties. They constitute feedstock materials to feed people and are reputed for their uses in medicines [1,2]. History of plants has been always related to that of Human.…”

Section: Introduction 11 General Statementmentioning

confidence: 99%

“…Research currently overflows in the literature related to the chemistry and biology of plants. Interests focus on experimental validation of ethnopharmacological uses of certain herb and formulation of plant extracts for a sustainable health care [1][2][3][4][5]. Therefore, plants are ground, exhausted and evaluated for various biological activity including properties to inhibit the growth of or to kill microorganisms and tumor cell lines.…”

Section: Introduction 11 General Statementmentioning

confidence: 99%

Plant-Derived Compounds against Microbial Infections and Cancers

Bitchagno¹,

Nchiozem-Ngnitedem²,

Wandji³

et al. 2021

Bioactive Compounds in Nutraceutical and Functional Food for Good Human Health

View full text Add to dashboard Cite

Plants synthesize and preserve a variety of metabolites known as natural products. Many of them are easily extractable and can be used as starting material or chemical scaffolds for various purposes, especially in drug discovery. Numbers of reports have listed valuable candidates with privilege scaffolds currently in active development as drugs. New compounds with anticancer and antiinfective activities have been discovered recently, some presented these backbones. The present book chapter aims to highlight these findings from plants which can be considered valuable for the development of new drugs against malignant cells and infective diseases. Interest in anti-infective agents is increasing due to the resistance of microorganisms to existing drugs and newly emerging infectious diseases. This resistance is also, nowadays, associated to some forms of cancers. In addition, the value of plants as essential part in the health care pipeline in low- and middle-income countries is under consideration even though these countries are almost all surrounded by a rich and untapped biodiversity. People are always relying on “modern drugs and treatment” which is unfortunately not affordable to all. Therefore, the present compilation of data on plant-derived compounds can inspire the formulation of ameliorated traditional medicines (ATM) against the targeted diseases and the conservation of species.

show abstract

Lemairones A and B: Two new antibacterial tetraflavonoids from the leaves of Zanthoxylum lemairei (Rutaceae)

Cited by 25 publications

References 28 publications

Antibacterial activity of flavonoids and their structure–activity relationship: An update review

Antibacterial activity of flavonoids and their structure–activity relationship: An update review

Zanthoxylum Species: A Review of Traditional Uses, Phytochemistry and Pharmacology in Relation to Cancer, Infectious Diseases and Sickle Cell Anemia

Plant-Derived Compounds against Microbial Infections and Cancers

Contact Info

Product

Resources

About