Lemon Pepper Extract Improves Diabetic Nephropathy in Diabetic Rats

Chiuman, Linda; Ginting, Chrismis Novalinda; Yulizal, OK

doi:10.3889/oamjms.2022.8226

Cited by 3 publications

(3 citation statements)

References 12 publications

(6 reference statements)

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“…Obtained filtrate was collected in a container to be evaporated by a rotary evaporator. Thus, it formed a concentrated Sunkist peel methanol extract (10)(11)(12).…”

Section: Methodsmentioning

confidence: 99%

The Antiacne Activity of Sunkist Peels Methanol Extract in Propionibacterium Acne-Induced Acne Vulgaris

Mutia,

Damayanti,

Suyono

et al. 2023

AVERROUS

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Treatment with acne vulgaris is a challenge because the complex pathophysiology of acne vulgaris. One of the natural products that potentially use as a herbal medicine is Sunkist peel. The peel of Sunkist is more inclined to end up as waste from domestic industries. The aim of this study was to investigate the antiacne activity of the Sunkist peel methanol extract gel in vivo study. The experimental study used by applied Sunkist peel extract gel to rats injected intradermally with Propionibacterium acne suspension. One hour before the injection of Propionibacterium acnes suspension, all rats were applied to a topical gel based on the group. Control, standard, Sunkist Peel Extract Gel-I, II, and III groups received gel base, clindamycin, 5%, 10%, and 15% of Sunkist peel extract gel, respectively. This study indicates the methanol extract of Sunkist orange peel with a yield of 8.73% revealed the presence of some phytochemicals, including alkaloids, flavonoids, tannins, and saponins. Sunkist orange peel methanol extract gel significantly reduced the size of acne vulgaris lesions after 7-14 days of extract application (p-value <0.05). It is in line with the histological study that the gel concentration increased, followed by the growth of the epidermal layer. This study sstrongly indicates that Sunkist orange peel methanol extract has an antiacne effect in a physically stable gel form.

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“…Obtained filtrate was collected in a container to be evaporated by a rotary evaporator. Thus, it formed a concentrated Sunkist peel methanol extract (10)(11)(12).…”

Section: Methodsmentioning

confidence: 99%

The Antiacne Activity of Sunkist Peels Methanol Extract in Propionibacterium Acne-Induced Acne Vulgaris

Mutia,

Damayanti,

Suyono

et al. 2023

AVERROUS

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“…After that, it was filtered, and the residue was macerated again in the same way. Meanwhile, all filtrate from all filtration processes was collected to evaporate by a rotary vacuum evaporator at 50 o C. Then, concentrated rose petal methanol extract was stored at 20 o C. (Suhartomi et al, 2020;Gulo et al, 2021;Chiuman, Ginting and Yulizal, 2022)…”

Section: Extraction Processmentioning

confidence: 99%

Liver Protection Effect of Red Rose Petal Methanol Extract in Copper-Induced Liver Injury in Male Wistar Rats

Hutagalung,

Girsang,

Mutia

et al. 2023

BIOMEDNATPROCH

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The human body requires low amounts of copper to maintain homeostasis, but high copper intake can cause various health problems. Many previous studies have been performed to look for natural products that can neutralize the excessive copper effect; one such natural product is a rose petal. Therefore, this study aims to investigate the liver protection effect of rose petals in copper-induced liver injury in male Wistar rats. This experimental study used thirty male Wistar rats that were grouped into five groups, including control, standard (quercetin), Rose Petal Methanol Extract-1 (400 mg/kg BW), 2 (800 mg/kg BW), and 3 (1,200 mg/kg BW). All groups were treated for 14 days, and all rats were given copper (II) sulfate suspension for the last three days. On the fifteenth day, all rats were sacrificed to obtain blood and liver tissue SGOT, SGPT, and liver histology study. The results showed that rose petal methanol extract significantly decreased SGOT and SGPT levels compared to the control group (P-value <0.05). The reduced area of ballooning degeneration and necrosis were in line with the increased dose of rose petal extract supported the liver protection effect of rose petal extract. Therefore, it can be concluded that rose petal methanol extract protects the liver against copper impacts.

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“…Due to these phytochemicals, some previous study showed that the lemon pepper extract has antidiabetic activity by oral administration which moreover may also prevent the microvascular complication against the liver and kidney. [9][10][11] On the other hand, other study by Purnama et al also reported that the lemon pepper essential oil has a wound healing activity against the burn wound in non-diabetic rats 12 . However, none of these previous studies that were investigated the wound healing activity against the oral ulcer in diabetic condition.…”

Section: Introductionmentioning

confidence: 99%

Oral Ulcer Healing Activity of Lemon Pepper Ethanol Extract Gel in Streptozotocin-Induced Diabetic Wistar Rats

Chiuman

Tanjung

et al. 2022

mkb

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Diabetes mellitus (DM) is a metabolic condition where the body's ability to produce and utilize insulin is impaired; thus, wound healing process is slower than usual in patients with DM. Lemon pepper has both antioxidant and anti-inflammatory properties. This study aimed to investigate the effect of topical application of lemon pepper fruit ethanol extracts on the healing process of oral traumatic ulcers in diabetic rats. This study was performed at the Pharmacology Laboratory, Faculty of Medicine, Universitas Prima Indonesia from September 2021–October 2021. Thirty males diabetic Wistar rats were thermally injured on the lower labial mucosa and divided into five groups: control, standard, and lemon pepper gel 5%, 7.5%, and 10% groups. The ulcer size was measured after injury and on the 7th and 14th day. On the last day, all rats underwent both routine blood count and histology study for oral ulcer tissue. On the 14th day, all treatment groups showed some significant difference wound contraction, with the highest tendency of wound contraction seen in both lemon pepper gel 10% and standard groups (62.50%. p-value =0.001). The improvement of wound contraction was also supported by reduced white blood cell count (p-value<0.05) in routine blood count and regeneration of epidermis and dermis tissues in the histology study. Hence, it can be concluded that the lemon pepper extract gel in all concentrations has good physical stability and the lemon pepper gel with the highest concentration group presents the best ulcer healing activity compared to other concentrations and has similar ulcer healing activity as the standard group that receives Kenalog® in Orabase.

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Lemon Pepper Extract Improves Diabetic Nephropathy in Diabetic Rats

Cited by 3 publications

References 12 publications

The Antiacne Activity of Sunkist Peels Methanol Extract in Propionibacterium Acne-Induced Acne Vulgaris

The Antiacne Activity of Sunkist Peels Methanol Extract in Propionibacterium Acne-Induced Acne Vulgaris

Liver Protection Effect of Red Rose Petal Methanol Extract in Copper-Induced Liver Injury in Male Wistar Rats

Oral Ulcer Healing Activity of Lemon Pepper Ethanol Extract Gel in Streptozotocin-Induced Diabetic Wistar Rats

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