Lemur Tyrosine Kinases and Prostate Cancer: A Literature Review

Ferrari, E; Naponelli, Valeria; Bettuzzi, Saverio

doi:10.3390/ijms22115453

Cited by 3 publications

(3 citation statements)

References 93 publications

(140 reference statements)

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“…43,44 Lemur receptor kinases (LMR/LMTK) are known to be associated with cancer and have an impact on multiple signaling pathways involved in cell proliferation, migration, and invasiveness. 45 The members of the anaplastic lymphoma kinase (ALK) receptor family consist of ALK and leukocyte tyrosine kinase (LTK). The fusion of the ALK genome is responsible for the formation of numerous tumors.…”

Section: Classification Of Rtksmentioning

confidence: 99%

“…The presence of the reactive oxygen species (ROS) receptor family has been observed in various malignant tumors, suggesting that this protein could be a promising target for anticancer drugs 43,44 . Lemur receptor kinases (LMR/LMTK) are known to be associated with cancer and have an impact on multiple signaling pathways involved in cell proliferation, migration, and invasiveness 45 …”

Section: Classification Of Rtksmentioning

confidence: 99%

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Receptor tyrosine kinases: biological functions and anticancer targeted therapy

Zhang,

2023

MedComm

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Receptor tyrosine kinases (RTKs) are a class of protein kinases that play crucial roles in various cellular processes, including cell migration, morphological differentiation, cell growth, and angiogenesis. In humans, 58 RTKs have been identified and categorized into 20 distinct families based on the composition of their extracellular regions. RTKs are primarily activated by specific ligands that bind to their extracellular region. They not only regulate tumor transformation, proliferation, metastasis, drug resistance, and angiogenesis, but also initiate and maintain the self‐renewal and cloning ability of cancer stem cells. Accurate diagnosis and grading of tumors with dysregulated RTKs are essential in clinical practice. There is a growing body of evidence supporting the benefits of RTKs‐targeted therapies for cancer patients, and researchers are actively exploring new targets and developing targeted agents. However, further optimization of RTK inhibitors is necessary to effectively target the diverse RTK alterations observed in human cancers. This review provides insights into the classification, structure, activation mechanisms, and expression of RTKs in tumors. It also highlights the research advances in RTKs targeted anticancer therapy and emphasizes their significance in optimizing cancer diagnosis and treatment strategies.

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Section: Classification Of Rtksmentioning

confidence: 99%

Section: Classification Of Rtksmentioning

confidence: 99%

Receptor tyrosine kinases: biological functions and anticancer targeted therapy

Zhang,

2023

MedComm

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“…CNL, chronic neutrophilic leukaemia; CRC, colorectal cancer; GBM, glioblastoma multiforme; GIST, gastrointestinal stromal tumour; NB, neuroblastoma; NSCLC, non-small-cell lung cancer; PDAC, pancreatic ductal adenocarcinoma. cancer type references bladder [ 14 ] breast [ 16 – 27 , 29 – 35 , 74 ] CNL [ 1 ] CRC [ 11 – 13 ] gastric [ 9 , 10 ] GBM [ 2 ] GIST [ 8 ] melanoma [ 8 ] NB [ 3 ] NSCLC [ 4 – 6 ] PDAC [ 28 ] prostate [ 15 , 35 , 75 ] thyroid [ 7 ] …”

Section: The Intricate Role Of Lmtk3 In Cancermentioning

confidence: 99%

The multifaceted role of lemur tyrosine kinase 3 in health and disease

et al. 2021

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In the last decade, LMTK3 (lemur tyrosine kinase 3) has emerged as an important player in breast cancer, contributing to the advancement of disease and the acquisition of resistance to therapy through a strikingly complex set of mechanisms. Although the knowledge of its physiological function is largely limited to receptor trafficking in neurons, there is mounting evidence that LMTK3 promotes oncogenesis in a wide variety of cancers. Recent studies have broadened our understanding of LMTK3 and demonstrated its importance in numerous signalling pathways, culminating in the identification of a potent and selective LMTK3 inhibitor. Here, we review the roles of LMTK3 in health and disease and discuss how this research may be used to develop novel therapeutics to advance cancer treatment.

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Therapeutic advances of targeting receptor tyrosine kinases in cancer

Tomuleasa,

Tigu,

Munteanu

et al. 2024

Sig Transduct Target Ther

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Receptor tyrosine kinases (RTKs), a category of transmembrane receptors, have gained significant clinical attention in oncology due to their central role in cancer pathogenesis. Genetic alterations, including mutations, amplifications, and overexpression of certain RTKs, are critical in creating environments conducive to tumor development. Following their discovery, extensive research has revealed how RTK dysregulation contributes to oncogenesis, with many cancer subtypes showing dependency on aberrant RTK signaling for their proliferation, survival and progression. These findings paved the way for targeted therapies that aim to inhibit crucial biological pathways in cancer. As a result, RTKs have emerged as primary targets in anticancer therapeutic development. Over the past two decades, this has led to the synthesis and clinical validation of numerous small molecule tyrosine kinase inhibitors (TKIs), now effectively utilized in treating various cancer types. In this manuscript we aim to provide a comprehensive understanding of the RTKs in the context of cancer. We explored the various alterations and overexpression of specific receptors across different malignancies, with special attention dedicated to the examination of current RTK inhibitors, highlighting their role as potential targeted therapies. By integrating the latest research findings and clinical evidence, we seek to elucidate the pivotal role of RTKs in cancer biology and the therapeutic efficacy of RTK inhibition with promising treatment outcomes.

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Lemur Tyrosine Kinases and Prostate Cancer: A Literature Review

Cited by 3 publications

References 93 publications

Receptor tyrosine kinases: biological functions and anticancer targeted therapy

Receptor tyrosine kinases: biological functions and anticancer targeted therapy

The multifaceted role of lemur tyrosine kinase 3 in health and disease

Therapeutic advances of targeting receptor tyrosine kinases in cancer

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