Lenalidomide-related Progressive Multifocal Leukoencephalopathy: A Case Report and Review of Drug-related Cases in Multiple Myeloma

Anderson, Stephanie; Kiernan, Matthew C.; Ho, P. Joy

doi:10.1016/j.clml.2018.12.021

Cited by 13 publications

(13 citation statements)

References 8 publications

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“…A very important cyclic imide moiety; Isoindoline-1, 3-dione commonly known as phthalimide, is the key structural unit of a variety of biologically active molecules which are of pharmaceutical significance. Various drugs such as lenalidomide, pomalidomide, etc., contain isoindoline structure and these drugs have been used for the treatment of multiple myeloma [34,35]. Various other isoindoline structure containing drugs are also known to be used for the treatment of certain types of diseases [36][37][38].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and in vitro antimicrobial activity of cyclic imide: Isoindoline-1, 3-dione derivatives

Baluja

Chanda

Kalpen

2019

GSC Biol. and Pharm. Sci.

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A series of new cyclic imide: isoindoline-1, 3-dione derivatives were synthesized by condensation of 2-hydrazinyl-2oxo-N-phenylacetamide and phthalic anhydride. The characterization of synthesized compounds was done by IR, 1 H NMR, 13 C NMR and mass spectroscopy. All these synthesized compounds were tested for in vitro antimicrobial against various bacterial and fungal strains in N, N-dimethyl formamide and Dimethyl sulfoxide. It is observed that almost all the compounds showed moderate antimicrobial activity and N, N-dimethyl formamide is better solvent than dimethyl sulfoxide.

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Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and in vitro antimicrobial activity of cyclic imide: Isoindoline-1, 3-dione derivatives

Baluja

Chanda

Kalpen

2019

GSC Biol. and Pharm. Sci.

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“…Lenalidomide-related neurological and psychiatric disorders, such as headache, dizziness, tremor, peripheral neuropathy, or anxiety may occur, although consciousness disorder is a rare complication ( 19 - 27 ). Ischemic stroke and progressive multifocal leukoencephalopathy are reported to be lenalidomide-related encephalopathies detectable with head MRI ( 28 , 29 ). Since head MRI showed no abnormal findings in this case, the possibility of lenalidomide-related encephalopathy was considered limited.…”

Section: Discussionmentioning

confidence: 99%

Vancomycin Intoxication and Cefepime-induced Encephalopathy Treated by Abdominal Drainage of Massive Ascites in Addition to Online Hemodiafiltration

et al. 2021

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A patient with recurrent plasmacytoma with massive ascites exhibited vancomycin intoxication and cefepime-induced encephalopathy due to renal dysfunction. The ascitic accumulation of these drugs was suspected because of the refractory intoxicated state. To remove these drugs that had accumulated in the blood and ascites, abdominal drainage was performed in addition to online hemodiafiltration. If patients with renal dysfunction and massive ascites develop vancomycin intoxication and cefepime-induced encephalopathy that cannot be improved by drug discontinuation, physicians should suspect ascitic accumulation and evaluate the ascitic concentration. Furthermore, if a high accumulation in massive ascites occurs, physicians should perform abdominal drainage along with blood purification.

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“…The patient received lenalidomide along with dexamethasone postautologous stem cell transplantation. 56…”

Section: Immunomodulatory Drugsmentioning

confidence: 99%

“…The last case of PML in an MM patient was reported in 2019. The patient received lenalidomide along with dexamethasone post‐autologous stem cell transplantation 56 …”

Section: Newer Therapies In Hematology Associated With Progressive Mu...mentioning

confidence: 99%

Progressive multifocal leukoencephalopathy in the context of newer therapies in hematology and review of new treatment strategies

Diamantopoulos

Kalopisis

Tsatsou

et al. 2022

European J of Haematology

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Progressive multifocal leukoencephalopathy (PML) is a rare, often fatal demyelinating disease of the central nervous system (CNS) caused by the reactivation of JC polyomavirus in the CNS. We present a case of a 54‐year‐old man with follicular lymphoma diagnosed with PML after being treated with anti‐CD20 monoclonal antibody‐based regimens for several years. Due to the lack of effective treatment choices for PML, the patient was treated with nivolumab, based on recent reports, but succumbed to his disease a few months after diagnosis. In this paper, we focus on reviewing the literature of PML cases correlated with newer agents used in hematology, possible factors affecting disease prognosis, as well as the available data on upcoming therapeutic options for patients with PML. Though newer promising treatments such as anti‐PD1 monoclonal antibodies arise, a definitive treatment option is yet to be found. Vigilance, early detection, and prompt intervention play a crucial role in the prognosis of PML in patients with hematological malignancies.

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Lenalidomide-related Progressive Multifocal Leukoencephalopathy: A Case Report and Review of Drug-related Cases in Multiple Myeloma

Cited by 13 publications

References 8 publications

Synthesis, characterization and in vitro antimicrobial activity of cyclic imide: Isoindoline-1, 3-dione derivatives

Synthesis, characterization and in vitro antimicrobial activity of cyclic imide: Isoindoline-1, 3-dione derivatives

Vancomycin Intoxication and Cefepime-induced Encephalopathy Treated by Abdominal Drainage of Massive Ascites in Addition to Online Hemodiafiltration

Progressive multifocal leukoencephalopathy in the context of newer therapies in hematology and review of new treatment strategies

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