Introduction:
To evaluate the morphological features of the crystalline lens in age-related cataract patients and to report the relationship of the lens nucleus sclerosis and axial length with lens morphology.
Methods
This retrospective cohort study were reviewed of age-related cataract patients scheduled for unilateral or bilateral cataract extraction with intraocular lens (IOL) implantation between July 2022 and June 2023 at Peking University Third Hospital. Preoperative examinations were conducted using a slit lamp, IOL Master 700 (Carl Zeiss, Germany), and CAISA2 (Tomey, Japan). Patients were categorized into different subgroups based on the degree of lens nucleus sclerosis (Emery-Little classification) and the axial length (AL), and statistical analysis was performed.
Results
285 left eyes were included in the study. The mean age of the included patients was 69.69 ± 9.34 years, and the mean axial length was 23.89 ± 1.79 mm. Nuclear lens sclerosis was observed to have a negative correlation with the CRLPS (r = -0.171, P < 0.01) and crystalline lens diameter (r = -0.143, P < 0.05). Conversely, nuclear lens sclerosis was observed to have a positive correlation with crystalline lens decentration (r = 0.117, P < 0.05). Statistically significant differences were found in the correlation of AL with CRLAS (r = 0.186, P < 0.05), CRLPS (r = 0.154, P < 0.05), crystalline lens diameter (r = 0.128, P < 0.05), crystalline lens decentration magnitude (r = 0.089, P < 0.05), and crystalline lens tilt magnitude (r = -0.256, P < 0.01), respectively. There were also differences among different subgroups. The crystalline lens with Emery-Little classification IV were performed with a smaller posterior surface curvature radius, a smaller crystalline lens diameter and greater decentration than those with Emery-Little classification I-III. The crystalline lens in short AL eyes were performed with a smaller anterior and posterior surfaces curvature radius, a smaller crystalline lens diameter than these in normal and long AL eyes. The crystalline lens in long AL eyes were performed with greater lens tilt and decentration.
Conclusion
Crystalline lens with Emery-Little classification IV were mainly performed with abnormality in lens morphology and lens decentration. Lens with short AL were performed with abnormality in lens morphology, while that with long AL were performed with abnormality in lens decentration and tilt.