Lentinan Properties in Anticancer Therapy: A Review on the Last 12-Year Literature

Abstract

Abstract:The effects of β-glucan in cancer are the most studied biological effects of β-glucan. From all available β-glucans, the most data are available on lentinan, mostly because it is used in clinical practice for over 20 years. Current review represent a state-of-the-art comprehensive review of knowledge obtained in last twelve years.

Accelerated Wound Healing on the Skin Using a Film Dressing with β-Glucan Paramylon

“…The yeast βglucans promote wound repair. The immunomodulatory properties of β-glucan have been known for decades and dietary supplements are commercially available with an aim to improve the health of individuals (10). Meta-analyses of clinical studies demonstrate the beneficial effects of β-1,3/1,6glucans lentinan in anticancer therapy (11,12).…”

Glucans and Cancer: Comparison of Commercially Available β-glucans – Part IV

“…Despite tens of thousands published papers on biological activities of glucan, it is often difficult to compare the effects as the majority of authors used glucans differing in source, size, or physicochemical properties. Despite numerous interesting reviews summarizing the current knowledge of glucan activities (24)(25)(26)(27), the best compare individual glucans against each other using identical experimental designs. In our previous studies, we directly compared over 50 individual glucans (12)(13)(14)(15)(16)18).…”

Combination Therapy with Glucan and Coenzyme Q10in Murine Experimental Autoimmune Disease and Cancer

“…Almost 80 years ago, Shear and coworkers isolated a substance causing tumor necrosis from the culture of Serratia marcescens (30). From this pioneering research, subsequent scientific interest has resulted in over 16,000 studies of glucan activities, making glucan the most studied natural immunomodulator; several in-depth reviews are available (20,(31)(32)(33)(34). Most of the glucan studies focused on cancer treatment (35).…”

“…β-Glucans are structurally complex homopolymers of glucose, isolated from various sources including yeast, fungi, and wheat. Their role as biologically active immunomodulators has been well documented for more than 50 years (17)(18)(19)(20). The positive effects of β-glucan treatment have been repeatedly confirmed in clinical trials (21).…”