Lentzea gen. nov., a New Genus of the Order Actinomycetales

Abstract

We describe a new genus of mesophilic actinomycetes, for which we propose the name Lentzea. The strains of this genus form abundant aerial hyphae that fragment into rod-shaped elements. Whole-cell hydrolysates contain the meso isomer of diaminopimelic acid and no characteristic sugar (wall chemotype 111). The phospholipid pattern type is type PI1 (phosphatidylethanolamine is the characteristic phospholipid); the major menaquinone is MK-9. The fatty acid profile comprises saturated, unsaturated, and branched-chain fatty acids of the is0 and anteiso types in addition to tuberculostearic acid (lOMe-C,,:,). A 16s ribosomal DNA sequence analysis revealed that the genus Lentzea is phylogenically related to the genera Actinosynnema, Sacchurothrix, and Kutzneria. The type species of this genus is Lentzea albidocupillatu sp. nov.; the type strain of this species is strain IMMIB D-958 (= DSM 44073).

Isolation and anti-HIV-1 integrase activity of lentzeosides A–F from extremotolerant lentzea sp. H45, a strain isolated from a high-altitude Atacama Desert soil

“…It is especially interesting that the new compounds, lentzosides A-F, are derived from a novel Lentzia strain as previously new specialized metabolites from Atacama Desert actinomycetes have come from novel Streptomyces strains, 7 notably from a deep seated 16S rRNA gene clade that can be equated with the species, Streptomyces leeuwenhoekii. [10][11][12][13][14][15][16] The genus Lentzia was validly published in 1995, 25 but to date does not appear to have been studied in terms of its natural product chemistry, though Lentzia sp. 7887 effects the biotransformation of FR901459, a novel derivative of cyclosporin.…”

Saccharothrix hoggarensis sp. nov., an actinomycete isolated from Saharan soil

“…Several species of this genus have been transferred to other new taxa, including the genera Lentzea (Yassin et al, 1995), Crossiella (Labeda, 2001), Lechevalieria , Goodfellowia (Labeda & Kroppenstedt, 2006) and Umezawaea (Labeda & Kroppenstedt, 2007). Currently, 12 species of the genus Saccharothrix have been described based on chemical analysis, physiological properties, cellular fatty acid composition, phylogeny and DNA-DNA hybridization data.…”

Natural product diversity of actinobacteria in the Atacama Desert

“…strain H45 which was isolated from a high-altitude Atacama Desert soil. The genus Lentzea was validly named over 20 years ago (Yassin et al 1995), but despite this it has not featured in natural product chemistry studies. Large scale fermentation of this strain led to the isolation of six new diene glycosides, lentzeosides A-F (26-31) together with the known monoene glycoside Z-3-hexenyl glucoside 32 (Wichner et al 2017).…”