Leopard spot retinopathy: an early clinical marker of leukaemia recurrence?

Robert, Matthieu P.; Faure, Céline; Miocque, S.

doi:10.1007/s00277-008-0510-z

Cited by 9 publications

(4 citation statements)

References 5 publications

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“…Such complications usually occur when a disease is clinically and hematologically active, but a case of acute lymphocytic leukemia was reported to show RPE dysfunction accompanied by serous retinal detachment ahead of the recurrence of leukemia that occurred a few months later. 3 Although the white spots in this case were not very similar to that reticular pattern, disappeared over time, and no hematological recurrence of leukemia was observed throughout the follow-up period, fundus white spots appeared 5 months before the recurrence at the molecular level. In addition, it is possible that the fundus white spots were the residue of retinal abnormalities due to direct infiltration of tumor cells found before BMT, since no ophthalmic examination was performed between the first visit to the eye clinic and our examination.…”

Section: Discussionmentioning

confidence: 55%

Fundus white spots associated with graft-versus-host disease in the remission phase of acute myeloid leukemia

Kyo

Yamamoto

Nagatomi

et al. 2022

American Journal of Ophthalmology Case Reports

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Section: Discussionmentioning

confidence: 55%

Fundus white spots associated with graft-versus-host disease in the remission phase of acute myeloid leukemia

Kyo

Yamamoto

Nagatomi

et al. 2022

American Journal of Ophthalmology Case Reports

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“…In contrast, involvement of the CNS is evidenced by leopard spot retinopathy and/or optic nerve infiltration. [23] Even though papilledema is well documented in the case of intracranial hypertension, it can also be secondary to a direct optic disc infiltration or due to an optic neuropathy induced by opportunistic infection. Lastly, we also observed ophthalmic relapses in our cohort occurring after immunotherapy, including blinatumomab or HSCT, indicative of a possible mechanism of immune resistance from leukemic cells.…”

Section: Discussionmentioning

confidence: 99%

Novel Insights into Pediatric Acute Lymphoblastic Leukemia Ophthalmic Relapses from a Nationwide Cohort Study

Louet¹,

Icart²,

Strullu³

et al. 2022

J. Cancer

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Ten to fifteen percent of children with acute lymphoblastic leukemia (ALL) relapse following treatment. Of these, less than 2% display ophthalmic relapses, which owing to their scarcity, are largely undocumented, leaving clinicians with few diagnostic and therapeutic recommendations, despite serious functional sequelae. We conducted a French multicenter retrospective study to collect all clinical, radiological, biological, and therapeutic data, and outcomes for children with ALL ophthalmic relapses. From 2000 to 2020, 20 ophthalmic relapses occurring after first-line therapy performed before January 1 st , 2017 were included in our study: 14 B-ALL and 6 T-ALL. Fifteen patients (75%) had concomitant involvement of the central nervous system, and 11 (55%) a combined bone marrow relapse. Only 1 had an isolated ophthalmic relapse. Eight children (40%) died, 7 from a refractory disease and 1 from toxic death, and 4 patients relapsed. With a median follow-up of 63.1 months, 8 patients are currently alive in continuous complete remission with only 2 displaying severe ophthalmic sequelae. Although rare, ophthalmic relapse could have a significant impact on the functional prognosis of survivors. Their management must be multidisciplinary, with a central role given to ophthalmologists.

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“…Additional factors such as drug toxicity have been postulated. [ 7 8 ] This could likely explain the permanent damage to the RPE as a sequela of malignancy or toxicity from chemotherapy. The slight delay in presentation could have also contributed to this sequela.…”

Section: Discussionmentioning

confidence: 99%

Bilateral serous retinal detachment

Kalbani

Hinai

Busaidi

2022

Oman Journal of Ophthalmology

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A 60-year-old female presented with acute onset painless loss of vision in both eyes. Clinical examination and ocular investigations revealed bilateral serous retinal detachments (SRDs) over the macula. There was no obvious intraocular or extraocular cause to the presentation. A blood count showed leukocytosis with the presence of blast cells on the peripheral smear. Further workup confirmed the diagnosis of Philadelphia chromosome-positive mixed phenotype acute leukemia with central nervous system disease stage three. Anatomic improvement in the SRD followed intensive intravenous and intrathecal chemotherapy. Limited functional improvement was attributed to the development of pigment epitheliopathy manifesting as leopard spot chorioretinopathy. This permanent disturbance could be attributed to leukemic infiltration and ischemia to the choroid.

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Leopard spot retinopathy: an early clinical marker of leukaemia recurrence?

Cited by 9 publications

References 5 publications

Fundus white spots associated with graft-versus-host disease in the remission phase of acute myeloid leukemia

Fundus white spots associated with graft-versus-host disease in the remission phase of acute myeloid leukemia

Novel Insights into Pediatric Acute Lymphoblastic Leukemia Ophthalmic Relapses from a Nationwide Cohort Study

Bilateral serous retinal detachment

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