LEP and LEPR are possibly a double‐edged sword for wound healing

Abstract

Wound healing is a complex and error‐prone process. Wound healing in adults often leads to the formation of scars, a type of fibrotic tissue that lacks skin appendages. Hypertrophic scars and keloids can also form when the wound‐healing process goes wrong. Leptin (Lep) and leptin receptors (LepRs) have recently been shown to affect multiple stages of wound healing. This effect, however, is paradoxical for scarless wound healing. On the one hand, Lep exerts pro‐inflammatory and profibrotic effects; on the other hand, Lep can regulate hair follicle growth. This paper summarises the role of Lep and LepRs on cells in different stages of wound healing, briefly introduces the process of wound healing and Lep and LepRs, and examines the possibility of promoting scarless wound healing through spatiotemporal, systemic, and local regulation of Lep levels and the binding of Lep and LepRs.

Unveiling heterogeneity in MSCs: exploring marker-based strategies for defining MSC subpopulations

“…Some other MSC markers have also been demonstrated, such as LepR (Leptin receptor) [270][271][272][273], CD34 [274][275][276], and TNFRSF10D [277]. However, their functions in MSCs remain unclear.…”

Screening of Lipid Metabolism-Related Genes as Diagnostic Indicators in Chronic Obstructive Pulmonary Disease

“…Besides regulating food intake and body weight, LEP and leptin receptors (LEPRs) also play an integral role in fetal growth, proinflammatory immune responses, angiogenesis and lipolysis. [36][37][38] Accordingly, elevated levels of LEP during lung inflammation and the presence of functional LEPR in the lungs suggest that LEP/LEPR play an important role in respiratory immune responses and the development of inflammatory respiratory diseases. 39 Among patients with moderate COPD, Broekhuizen et al 40 found that leptin levels were detected in induced sputum and were significantly correlated with C-reactive protein and total TNF-α.…”