Leprosy and the testis

Rodríguez, Gerzaín; Abaúnza, María Claudia; Vargas, Elga Johanna; López, Fernándo

doi:10.7705/biomedica.v32i1.616

Cited by 3 publications

(2 citation statements)

References 19 publications

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“…Narang et al 23 India 1 Started rationale dose but patient not tolerated (apremilast) 1 Yes 7 Barman et al 24 India 1 MDT, Thalidomide - 100mg, T. Prednisolone. 0 No 8 Richards 25 Pt from Micronesia- treated at Dallas, Texas 1 MDT, Prednisolone 60mg/day, Thalidomide - 100mg 0 No, Not always mandatory 9 Rodriguez 26 Colombia 1 MDT, Thalidomide 300mg/day, Prednisolone 50mg/day 0 No, Not always mandatory 10 Verma et al 27 India 1 MDT, Prednisolone 40mg/day, Thalidomide 100mg TDS, Azathiprine 50mg/twice daily. 0 No 11 Verma et al 27 India 1 MDT,Prednisolone 1mg/kg/day, Thallidomide 100mg QID for 4 months 0 No 12 Yogeesh HR et al …”

Section: Resultsmentioning

confidence: 99%

Rationale use of Thalidomide in erythema nodosum leprosum - A non-systematic critical analysis of published case reports

Thangaraju

Venkatesan

Gurunthalingam

et al. 2020

Rev. Soc. Bras. Med. Trop.

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Introduction: Thalidomide is an anti-tumor necrosis factor alpha (TNF-a) drug used mainly in the management of moderate to severe form of Erythema Nodosum Leprosum (ENL). Because of its teratogenic potential it has to be used under proper supervision. Our critical analysis tries to look into the rationale with which it has been used by means of case reports on lepra reaction. Methods: We looked for the case reports between December 2005 to June 2019 in databases like Pubmed, Embase and other relevant resources. We used search words like "erythema nodosum leprosum(ENL)", "thalidomide", "case report" in different combinations to get relevant reports that focus on thalidomide usage atleast once at any time point during management. The information extracted were indication of thalidomide use, dose, response, outcome, complication if any, along with all the demographic details and geographical distribution. Results: We found 41 case reports eligible for analysis.The information was critically evaluated. From the analysis it was found that 7 of the case report mentioned the exact indication, 4 case report showed irrational use of thalidomide in the case of neuritis without use of steroids, 7 showed proper use of Clofazimine prior to thalidomide initiation, 26 case report showed case report of rationale dose range and in 4 case reports clofazimine was used prior to thalidomide along with the rational dose of thalidomide. Conclusions: This analysis helps to guide the rationale use of thalidomide focussing on few important points that anyone should keep in mind while managing a case of ENL.

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Section: Resultsmentioning

confidence: 99%

Rationale use of Thalidomide in erythema nodosum leprosum - A non-systematic critical analysis of published case reports

Thangaraju

Venkatesan

Gurunthalingam

et al. 2020

Rev. Soc. Bras. Med. Trop.

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“…Testicular involvement is seen in 44–87 % of patients with LL, most commonly presenting as testicular atrophy, azoospermia, and hypogonadism [6] , [7] . The few described cases of testicular ENL have presented as generalized testicular tenderness and have been treated with MB-MDT, thalidomide, corticosteroids or orchiectomy in persistent cases; none have presented as intratesticular masses [7] , [8] . Intratesticular masses are managed by measurement of tumor markers and pertinent imaging studies.…”

Section: Discussionmentioning

confidence: 99%

Erythema nodosum leprosum: A rare cause of testicular nodules

Figueroa-Diaz

Cordero-Pacheco

Quintero-Noriega

2023

IDCases

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Recidiva de lepra y reacción tipo II en paciente tratado con poliquimioterapia (PQT)

Padilla

González

Celis

2014

nova

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ResumenLa lepra es una enfermedad infecciosa crónica propia de países de África, Asia, Oceanía y América Latina. Es causada por el Mycobacterium leprae que se manifiesta de forma variada como zonas de hipo o anestesia, máculas hipocrómicas, con o sin engrosamiento neural. En algunas ocasiones, después de haber completado el ciclo terapéutico recomendado por la Organización Mundial de la Salud, puede presentar recidivas, apareciendo nuevas lesiones clínicas o aumentando el índice bacilar. Esta características pueden confundirse con el eritema nodoso leproso, caracterizado por ser una reacción antígeno-anticuerpo que fija complemento mediante la cual el sistema inmune combate antígenos bacilares. En este texto se describe un caso de recidiva de lepra lepromatosa y lesiones compatibles con eritema nodoso leproso después de haber sido tratado con poliquimioterapia.Palabras clave: índice bacilar, lepra, poliquimioterapia, recidiva. Relapse in leprosy and type II reaction in a patient treated with multidrug therapy (MDT) AbstractLeprosy is a chronic infectious disease endemic to African, Asian, Latin America and South Pacific countries. It is caused by Mycobacterium leprae that manifests itself as varied as areas of hypo or anesthesia, macules hypochromic, with or without neura thickening. On some occasions, after having completed the course of therapy recommended by the World Health Organization, it can recur, showing new clinical lesions or increasing the bacillary index. These features can be confused with erythema nodosum leprosum, characterized by an antigen-antibody reaction that secures a complement through which the immune system combats antigen cells. This text describes a case of recurrence of lepromatous leprosy and lesions compatible with erythema nodosum leprosum after it has been treated with combination chemotherapy.

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Leprosy and the testis

Cited by 3 publications

References 19 publications

Rationale use of Thalidomide in erythema nodosum leprosum - A non-systematic critical analysis of published case reports

Rationale use of Thalidomide in erythema nodosum leprosum - A non-systematic critical analysis of published case reports

Erythema nodosum leprosum: A rare cause of testicular nodules

Recidiva de lepra y reacción tipo II en paciente tratado con poliquimioterapia (PQT)

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