The study is devoted to the historiography of the fight against epidemics in Yakutia in the 19th century. The purpose of the study is to present the development of historical knowledge about this sequential process, taking into account the characteristics of the stages of historiography. The materials and methods used were the studied works, typical for historiographical works, devoted to the fight against epidemics in the specified period, typological and comparative analysis. For the first time, the most important works were developed, which studied the measures taken by state authorities to prevent epidemic diseases that caused significant harm to the population of the region (smallpox, measles, venereal diseases, etc.), to treat them, and to create conditions for successfully combating them. Also of interest were works examining the history of healthcare institutions (in fact, the first on the territory of Yakutia) and the first medical personnel who contributed in this direction. All this is presented for the first time in this article and brings a lot of new things into the understanding of the historical processes that took place on one of the remote outskirts of the Russian Empire. Particular attention is paid to exactly what problems occupied a leading place in this area of historiography. For example, researchers were more interested not only in organizing a network of medical institutions that maintained a positive epidemiological level in the region, but also in specific measures taken by the authorities to combat the spread of certain diseases. The authors drew comparative material from historical experience from other regions of the Empire, where the fight against epidemics was also carried out with varying degrees of success. All this allowed the authors to identify the features of the development of Yakut historiography in this area of scientific knowledge.