Leprosy in pregnancy – a review of the literature

Fatola, Christiana Oluwashola; Venyo, Anthony Kodzo-Grey; Venyo, Lucy Kodzo-Grey; Maloney, Douglas John Lindsay

doi:10.7707/hmj.320

Cited by 2 publications

(1 citation statement)

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“…leprae antibodies are present in 30% of cord sera of babies of mothers with active LL [82]. These children have a lower birth weight than the average and suffer from fetal distress [55,83,84]. Moreover, children born to mothers with leprosy are at increased risk of developing leprosy.…”

Section: Discussionmentioning

confidence: 99%

Possible cases of leprosy from the Late Copper Age (3780-3650 cal BC) in Hungary

et al. 2017

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At the Abony-Turjányos dűlő site, located in Central Hungary, a rescue excavation was carried out. More than 400 features were excavated and dated to the Protoboleráz horizon, at the beginning of the Late Copper Age in the Carpathian Basin, between 3780–3650 cal BC. Besides the domestic and economic units, there were two special areas, with nine-nine pits that differed from the other archaeological features of the site. In the northern pit group seven pits contained human remains belonging to 48 individuals. Some of them were buried carefully, while others were thrown into the pits. The aim of this study is to present the results of the paleopathological and molecular analysis of human remains from this Late Copper Age site. The ratio of neonates to adults was high, 33.3%. Examination of the skeletons revealed a large number of pathological cases, enabling reconstruction of the health profile of the buried individuals. Based on the appearance and frequency of healed ante- and peri mortem trauma, inter-personal (intra-group) violence was characteristic in the Abony Late Copper Age population. However other traces of paleopathology were observed on the bones that appear not to have been caused by warfare or inter-group violence. The remains of one individual demonstrated a rare set of bone lesions that indicate the possible presence of leprosy (Hansen’s disease). The most characteristic lesions occurred on the bones of the face, including erosion of the nasal aperture, atrophy of the anterior nasal spine, inflammation of the nasal bone and porosity on both the maxilla and the bones of the lower legs. In a further four cases, leprosy infection is suspected but other infections cannot be excluded. The morphologically diagnosed possible leprosy case significantly modifies our knowledge about the timescale and geographic spread of this specific infectious disease. However, it is not possible to determine the potential connections between the cases of possible leprosy and the special burial circumstances.

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Section: Discussionmentioning

confidence: 99%

Possible cases of leprosy from the Late Copper Age (3780-3650 cal BC) in Hungary

et al. 2017

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Dynamic Immune Status of Pregnancy and Dermatological Diseases

Parthasarathy

Janagond

Inamadar

et al. 2021

Clinical Dermatology Review

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Dynamic changes of immune system in the various stages of pregnancy affect the course of various diseases afflicting the mother alongside determining how pregnancy affects these diseases. To understand this, a thorough knowledge on how the immune system differs in pregnancy is essential. The complex interplay between the maternal and fetal immune systems via placenta in order to maintain the pregnancy leads to waxing and waning of immune responses in both mother and fetus. This dynamic nature of immune responses can heavily influence the manifestations and severity of several dermatological diseases, whether infectious or noninfectious. Here, we discuss the effect of altered immunity of gestation on a few important dermatological diseases such as psoriasis, systemic lupus erythematosus, syphilis, varicella, leprosy, and TORCH infections and vice versa.

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Leprosy in pregnancy – a review of the literature

Cited by 2 publications

References 0 publications

Possible cases of leprosy from the Late Copper Age (3780-3650 cal BC) in Hungary

Possible cases of leprosy from the Late Copper Age (3780-3650 cal BC) in Hungary

Dynamic Immune Status of Pregnancy and Dermatological Diseases

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