Leptin and adiponectin are valuable serum markers explaining obesity/bronchial asthma interrelationship

Salah, Adel; Ragab, Mostafa; Mansour, W.; Taher, Mahboobe

doi:10.1016/j.ejcdt.2015.02.012

Cited by 15 publications

(13 citation statements)

References 22 publications

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“…Obese T2DM and obese non-diabetic had a significantly lower level of serum adiponectin as compared to lean T2DM and healthy control, respectively. Serum adiponectin level was decreased in obese subjects with and without diabetes, a similar trend was also seen in this study [26,27]. Decreased level of adiponectin has been strongly associated with IR and inflammation was seen as the main cause of the link between obesity and T2DM [28].…”

Section: Discussionsupporting

confidence: 88%

Study of Relationship Between the Protein Oxidation Markers and Adipokines in Obese Type 2 Diabetic Patients

Singh

Mahajan

Kaur

2019

Asian J Pharm Clin Res

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Objective: This study was done to explore the correlation if any, between obesity markers adiponectin, leptin, and protein oxidative stress (OS) status in obese with and without type 2 diabetic mellitus (T2DM) patients. Methods: In the present study, 30 healthy subjects, 30 obese non-diabetics, and 30 obese T2DM patients were enrolled. Protein OS parameters such as advanced oxidation of protein products (AOPPs) and protein carbonyl (PC) were estimated. Serum leptin, adiponectin, and insulin levels were measured by ELISA. Results: The AOPP, PC, leptin, leptin adiponectin ratio (LAR), insulin, and homeostasis model assessment of insulin resistance (HOMA-IR) levels were significantly higher in obese non-diabetic and obese T2DM as compared to healthy control (p<0.001). However, serum adiponectin levels were significantly lower in obese non-diabetic and obese T2DM as compared to control (p<0.001). HOMA-IR and LAR both the index of IR were increased in obese non-diabetic and obese T2DM. Positive correlations were observed for AOPP with body mass index, PC in obese non-diabetic and with fasting blood glucose, postprandial blood glucose, HOMA-IR, and PC in obese T2DM. A negative correlation was found between PC and adiponectin in obese non-diabetic and obese T2DM. A significant inverse correlation was obtained between leptin and adiponectin in obese T2DM only. Conclusion: The present study suggested that increased protein OS, hyperinsulinemia, and hyperleptinemia may lead to hypoadiponectinemia in obese with and without T2DM. Moreover, determination of protein oxidation markers can be useful for monitoring the dysregulation of adipokines and glucose metabolism in obesity and T2DM.

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Section: Discussionsupporting

confidence: 88%

Study of Relationship Between the Protein Oxidation Markers and Adipokines in Obese Type 2 Diabetic Patients

Singh

Mahajan

Kaur

2019

Asian J Pharm Clin Res

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“…Pro-inflammatory molecules such as TNF-α and IL-6 inhibit the production of adiponectin and typical anti-inflammatory adipokines. The serum concentrations of pro-inflammatory adipokines increased with obesity, whereas serum adiponectin concentrations were lower in obese individuals [52, 53]. Thus, chronic systemic inflammation in obese individuals may increase their susceptibility to airway obstruction and bronchial hyper-responsiveness [54].…”

Section: Discussionmentioning

confidence: 99%

Sex differences in the association between asthma incidence and modifiable risk factors in Korean middle-aged and older adults: NHIS-HEALS 10-year cohort

2019

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BackgroundThis study investigated the sex-specific incidence of asthma and the effects of modifiable risk factors, particularly obesity, on asthma incidence among middle-aged and older individuals in Korea.MethodsWe used data from the National Health Insurance Service-Health Screening Cohort (NHIS-HEALS), which includes health examinees aged 40–79 years in 2002–2003. In total, 459,529 participants with baseline anthropometric measurements were followed-up for 10 years and the development of asthma was evaluated (2004–2013). For subgroup analysis, 246,019 participants who had body mass index (BMI) and waist circumference (WC) measurements taken in 2008–2009 were included in the analysis of the asthma incidence for 2010–2013. Factors associated with asthma were analysed using Cox proportional hazard models.ResultsThe cohort comprised 4,248,813 (men, 2,358,541; women, 1,890,272) person-years of follow-up for 2004–2013. The asthma incidence was 10.58 and 15.03 per 1000 person-years for men and women, respectively. Asthma incidence increased with age, notably so in men. Obesity based on the baseline BMI was significantly associated with asthma development in both sexes (men, HR = 1.23, 95% confidence interval (CI) = 1.13–1.34; women, HR = 1.40 95% CI = 1.32–1.48). High WC was also related to asthma incidence in both sexes with statistical significance (men, HR = 1.34, 95% CI = 1.16–1.57; women, HR = 1.19 95% CI = 1.03–1.37). Analysis of the combined effects of BMI and WC showed that men had a higher asthma risk in the group with both general obesity and abdominal obesity than in the group with non-abdominal obesity and normal BMI. However, obese women had a higher risk of asthma regardless of abdominal obesity. Similarly, smoking was associated with asthma in both sexes but drinking and physical activity showed different associations between the sexes.ConclusionsOur results revealed that asthma incidence was substantially high at old age and lifestyle factors were associated with asthma development. Practical strategies including weight control and healthy lifestyle modification are required to prevent asthma in older people.

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“…There is no evidence that leptin is a direct cause of asthma. However, several studies have demonstrated that leptin is correlated with obesity and asthma in both adults and children [ 69 , 76 , 77 ]. Adiponectin is an anti-inflammatory adipokine produced by adipose tissue [ 78 ].…”

Section: Obesity and Asthmamentioning

confidence: 99%

Obesity-Related Asthma: Immune Regulation and Potential Targeted Therapies

Yuan

Ran

Xiong

et al. 2018

Journal of Immunology Research

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Obesity, one of the most severe public health problems of the 21st century, is a common metabolic syndrome due to excess body fat. The incidence and severity of obesity-related asthma have undergone a dramatic increase. Because obesity-related asthma is poorly controlled using conventional therapies, alternative and complementary therapies are urgently needed. Lipid metabolism may be abnormal in obesity-related asthma, and immune modulation therapies need to be investigated. Herein, we describe the immune regulators of lipid metabolism in obesity as well as the interplay of obesity and asthma. These lay the foundations for targeted therapies in terms of direct and indirect immune regulators of lipid metabolism, which ultimately help provide effective control of obesity-related asthma with a feasible treatment strategy.

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Leptin and adiponectin are valuable serum markers explaining obesity/bronchial asthma interrelationship

Cited by 15 publications

References 22 publications

Study of Relationship Between the Protein Oxidation Markers and Adipokines in Obese Type 2 Diabetic Patients

Study of Relationship Between the Protein Oxidation Markers and Adipokines in Obese Type 2 Diabetic Patients

Sex differences in the association between asthma incidence and modifiable risk factors in Korean middle-aged and older adults: NHIS-HEALS 10-year cohort

Obesity-Related Asthma: Immune Regulation and Potential Targeted Therapies

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