Leptin in depression: a potential therapeutic target

Ge, Tongtong; Fan, Jie; Yang, Wei; Cui, Ranji; Li, Bingjin

doi:10.1038/s41419-018-1129-1

Cited by 75 publications

(62 citation statements)

References 102 publications

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“…Thus, leptin signaling stimulates pro-inflammatory cytokine secretion and influences cortisol release, serotonin and dopaminergic pathways, brain-derived neurotrophic factor (BDNF) signaling and hippocampal synaptic plasticity [93]. Altered leptin levels have been implicated in depression [94]. Elevated early childhood leptin levels in plasma, but not in cord blood, have been associated with an increased risk for autism [95], and associations between leptin levels and other behaviors have been reported from rodent models [93].…”

Section: Metabolic Hormonesmentioning

confidence: 99%

Relationship of prenatal maternal obesity and diabetes to offspring neurodevelopmental and psychiatric disorders: a narrative review

et al. 2020

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Obesity and diabetes is a worldwide public health problem among women of reproductive age. This narrative review highlights recent epidemiological studies regarding associations of maternal obesity and diabetes with neurodevelopmental and psychiatric disorders in offspring, and provides an overview of plausible underlying mechanisms and challenges for future human studies. A comprehensive search strategy selected terms that corresponded to the domains of interest (maternal obesity, different types of diabetes, offspring cognitive functions and neuropsychiatric disorders). The databases searched for articles published between January 2010 and April 2019 were PubMed, Web of Science and CINAHL. Evidence from epidemiological studies strongly suggests that maternal pre-pregnancy obesity is associated with increased risks for autism spectrum disorder, attention-deficit hyperactivity disorder and cognitive dysfunction with modest effect sizes, and that maternal diabetes is associated with the risk of the former two disorders. The influence of maternal obesity on other psychiatric disorders is less well studied, but there are reports of associations with increased risks for offspring depression, anxiety, schizophrenia and eating disorders, at modest effect sizes. It remains unclear whether these associations are due to intrauterine mechanisms or explained by confounding family-based sociodemographic, lifestyle and genetic factors. The plausible underlying mechanisms have been explored primarily in animal models, and are yet to be further investigated in human studies.

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Section: Metabolic Hormonesmentioning

confidence: 99%

Relationship of prenatal maternal obesity and diabetes to offspring neurodevelopmental and psychiatric disorders: a narrative review

et al. 2020

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“…Modifications of leptin metabolism and its gene expression, as well as its receptor, have been reported among patients with mental health disorders, independently to psychotropic drugs or in absence of antipsychotics [43]. Several studies showed a particular interest in the relationship between leptin and depressive disorders, but with discordant conclusions [42][43][44][45].…”

Section: Leptin and Psychiatric Illnessesmentioning

confidence: 99%

Leptin and psychiatric illnesses: does leptin play a role in antipsychotic-induced weight gain?

et al. 2020

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Antipsychotic-induced weight gain is the most prevalent somatic adverse event occurring in patients treated by antipsychotics, especially atypical antipsychotics. It is of particular interest because of its repercussion on cardiovascular morbidity and mortality especially now that the use of second-generation antipsychotics has been extended to other mental health illnesses such as bipolar disorders and major depressive disorder. The mechanism underlying antipsychotics-induced weight gain is still poorly understood despite a significant amount of work on the topic. Recently, there has been an ongoing debate of tremendous research interest on the relationship between antipsychotic-induced weight gain and body weight regulatory hormones such as leptin. Given that, researchers have brought to light the question of leptin's role in antipsychotic-induced weight gain. Here we summarize and discuss the existing evidence on the link between leptin and weight gain related to antipsychotic drugs, especially atypical antipsychotics.

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“…If increased leptin occurs in the absence of satiety behaviours, but rather in association with depressogenic increased eating corresponding to leptin resistance, this may be a potential therapeutic target to address problematic eating and weight gain risk in a large subset of individuals with MDD, particularly females. The potential of leptin as a therapeutic target for other symptoms in MDD is currently being considered (Ge et al, 2018), however its potential role in weight gain associated with MDD has received little consideration to date.…”

Section: Discussionmentioning

confidence: 99%

Weight gain in Major Depressive Disorder: Linking appetite and disordered eating to leptin and ghrelin.

Mills

Larkin

Deng

et al. 2019

Psychiatry Research

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Major Depressive Disorder (MDD) involves changes in appetite and weight, with a subset of individuals at an increased risk of weight gain. Pathways to weight gain may include appetite disturbances, excess eating, and dysregulation of appetite hormones. However, little research has simultaneously examined relationships between hormones, eating behaviours and MDD symptoms. Plasma ghrelin and leptin, biometrics, eating behaviours and psychopathology were compared between depressed (n = 60) and control (n = 60) participants. Depressed participants were subcategorised into those with increased or decreased appetite/ weight for comparison by subtype. The Dutch Eating Behaviours Questionnaire and Yale Food Addiction Scale measured eating behaviours. Disordered eating was higher in MDD than controls, in females than males, and in depressed individuals with increased, compared to decreased, appetite/weight. Leptin levels were higher in females only. Leptin levels correlated positively, and ghrelin negatively, with disordered eating. The results provide further evidence for high levels of disordered eating in MDD, particularly in females. The correlations suggest that excessive eating in MDD is significantly linked to appetite hormones, indicating that it involves physiological, rather than purely psychological, factors. Further, longitudinal, research is needed to better understand whether hormonal factors play a causal role in excessive eating in MDD.

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Leptin in depression: a potential therapeutic target

Cited by 75 publications

References 102 publications

Relationship of prenatal maternal obesity and diabetes to offspring neurodevelopmental and psychiatric disorders: a narrative review

Relationship of prenatal maternal obesity and diabetes to offspring neurodevelopmental and psychiatric disorders: a narrative review

Leptin and psychiatric illnesses: does leptin play a role in antipsychotic-induced weight gain?

Weight gain in Major Depressive Disorder: Linking appetite and disordered eating to leptin and ghrelin.

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