Leptin levels in pregnancy, marker for fat accumulation and mobilization?

Sattar, Naveed; Greer, Ian A.; Pirwani, Imran A.; Gibson, Jennifer A.; Wallace, Andrew M.

doi:10.1034/j.1600-0412.1998.770304.x

Cited by 74 publications

(77 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A similar correlation is also observed during pregnancy [57], where plasma leptin peaks in the late phase of the second trimester and relates to BMI post-partum. Interestingly, although BMI before and during pregnancy was similar between groups and overall maternal weight gain even lower in women with gestational diabetes, BMI post-partum remained significantly higher in women with gestational diabetes than in the women with normal glucose tolerance and Type I diabetes.…”

Section: Discussionsupporting

confidence: 56%

Increased plasma leptin in gestational diabetes

Kautzky‐Willer

Pacini²,

Tura³

et al. 2001

Diabetologia

171

127

View full text Add to dashboard Cite

Leptin, a polypeptide hormone originating from adipocytes, contributes to body weight control and provides negative feedback between adipose tissue and the hypothalamic satiety centre. In animal models, leptin decreases food intake but increases energy expenditure and body temperature [1±3]. Furthermore, it is found to be higher in women than in men [4] and to influence the reproductive function [5]. In humans plasma leptin is highly correlated with body fat Diabetologia (2001) Abstract Aims/hypothesis. Insulin resistance as well as marked changes in body weight and energy metabolism are associated with pregnancy. Its impact on plasma leptin is not known and was determined in this longitudinal study in both diabetic and normal pregnancy. Methods. At 28 gestational weeks plasma concentrations of leptin and B-cell hormones were measured at fasting and after an oral glucose load (OGTT:75 g) in women with gestational diabetes and pregnant women with normal glucose tolerance and compared with women who were not pregnant (C).Results. Plasma leptin (ng/ml) was higher (p < 0.001) in women with gestational diabetes (24.9 1.6) than in women with normal glucose tolerance (18.2 1.5) and increased in both groups when compared with the non-pregnant women (8.2 1.3; p < 0.0005). No change in plasma leptin concentrations was induced by OGTT in any group. Basal insulin release was higher (p < 0.05) in women with gestational diabetes compared with the pregnant women with normal glucose tolerance. Marked insulin resistance was confirmed by a 20 % lower (p < 0.05) insulin sensitivity in subgroup analysis and a decrease of almost 40 % in fasting glucose/insulin ratio (p < 0.005) in women with gestational diabetes. Leptin correlated in women with gestational diabetes with basal plasma concentrations of glucose (p < 0.02), insulin (p < 0.004) and proinsulin (p < 0.01) as well as with BMI (p < 0.001) and overall pregnancy induced maternal weight gain (p < 0.009). With normalisation of blood glucose 8 weeks after delivery in women with gestational diabetes their plasma leptin decreased (p < 0.0005) to 17.3 1.9 ng/ml but did not completely normalize (p < 0.05 vs non-pregnant women). Conclusion/interpretation. Our data show that women with gestational diabetes without any change in plasma leptin upon oral glucose loading have increased plasma leptin concentrations during and after pregnancy, a clear association of plasma leptin with the respective concentration of glucose and insulin resistance as well as with changes in body weight, and a failure to normalize spontaneously BMI to the same extent as pregnant women with normal glucose tolerance when compared with matched control subjects. [Diabetologia (2001) 44: 164±172]

show abstract

Section: Discussionsupporting

confidence: 56%

Increased plasma leptin in gestational diabetes

Kautzky‐Willer

Pacini²,

Tura³

et al. 2001

Diabetologia

171

127

View full text Add to dashboard Cite

show abstract

“…As in many other studies (Butte et al, 1997;Lage et al, 1999;Sattar et al, 1998;Schrubing et al, 1998;Tamura et al, 1998), plasma leptin concentrations were signi®cantly higher in pregnant women when compared to non-pregnant women. Our study further indicated that this pregnancyrelated increase in leptin concentration starts within the ®rst 2 ± 3 weeks after conception.…”

Section: Discussionsupporting

confidence: 83%

“…An explanation for the lack of an association between leptin concentration and the total amount of phospholipidassociated fatty acids during late pregnancy could be that the women became leptin resistant. Many investigators proposed such a leptin resistant state during pregnancy (Chehab, 1997;Hardie et al, 1997;Highman et al, 1998;Mounzih et al, 1998;Sattar et al, 1998;Schrubing et al, 1997). They believe that this putative insensitivity to leptin could be of physiologic importance.…”

Section: Discussionmentioning

confidence: 99%

“…Serum leptin concentrations are strongly associated to body fatness in adults, children and infants Clapp & Kiess, 1998;Considine et al, 1996;Ellis & Nicolson, 1997;Marchini et al, 1998). During pregnancy, a marked increase in the maternal serum leptin concentration occurs, which is followed by a sharp decrease immediately after delivery (Butte et al, 1997;Hardie et al, 1997;Sattar et al, 1998;Schrubing et al, 1998). Several studies have demonstrated that, aside from adipose tissue, the human placenta also synthesizes leptin (Masuzaki et al, 1997;Sen Äaris et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Leptin and phospholipid-esterified docosahexaenoic acid concentrations in plasma of women: observations during pregnancy and lactation

Rump

Otto

Hornstra³

2001

Eur J Clin Nutr

View full text Add to dashboard Cite

Background: The n-3 fatty acid status changes during pregnancy and lactation. Plasma leptin concentrations and gene expression have been related to n-3 fatty acids. Objective: To investigate the relation between plasma leptin concentration and the docosahexaenoic acid (22:6n-3) content of plasma phospholipids during early pregnancy and the postpartum period. Design: Leptin (radioimmunoassay) and the phospholipid fatty acid pro®le (capillary gas-liquid chromatography) were measured in plasma of women during two independent longitudinal observational studies. Dietary intake of n-3 fatty acids was also determined. Results: Within the ®rst 10 weeks after the last menstrual period, an almost parallel increase in leptin concentration and the 22:6n-3 content (mgal and % wtawt) of plasma phospholipids was seen (study 1, n 21). During the postpartum period (study 2, n 57), leptin levels decreased quickly, preceding the changes in 22:6n-3 concentrations. During both studies, leptin concentrations did not consistently relate to dietary intake of n-3 fatty acids or to 22:6n-3 concentrations in plasma phospholipids. Before and during early pregnancy (study 1), signi®cant positive associations between leptin levels and the total amount of phospholipid-associated fatty acids were found. No such association was seen during late pregnancy or the postpartum period (study 2). The postpartum decrease in leptin levels did not differ between lactating and non-lactating women. Conclusions: Not the 22:6n-3 content, but the total amount of phospholipid-associated fatty acids was related to plasma leptin concentration, before and during early pregnancy but not during late pregnancy and the postpartum period. Sponsorship: Dutch Organization for Scienti®c Research (NWO, grant no. 904 62 186).

show abstract

“…It is well known that serum leptin levels are higher in pregnant as compared to non-pregnant women [115][116][117]. Moreover, serum leptinemia correlates with maternal body weight [118].…”

Section: Role Of Leptin In Pregnancymentioning

confidence: 99%

Role of leptin in female reproduction

Pérez-Pérez

Sánchez-Jiménez

Maymó

et al. 2015

Clinical Chemistry and Laboratory Medicine (CCLM)

127

View full text Add to dashboard Cite

Abstract:Reproductive function is dependent on energy resources. The role of weight, body composition, fat distribution and the effect of diet have been largely investigated in experimental female animals as well as in women. Any alteration in diet and/or weight may induce abnormalities in timing of sexual maturation and fertility. However, the cellular mechanisms involved in the fine coordination of energy balance and reproduction are largely unknown. The brain and hypothalamic structures receive endocrine and/or metabolic signals providing information on the nutritional status and the degree of fat stores. Adipose tissue acts both as a store of energy and as an active endocrine organ, secreting a large number of biologically important molecules termed adipokines. Adipokines have been shown to be involved in regulation of the reproductive functions. The first adipokine described was leptin. Extensive research over the last 10 years has shown that leptin is not only an adipose tissue-derived messenger of the amount of energy stores to the brain, but also a crucial hormone/cytokine for a number of diverse physiological processes, such as inflammation, angiogenesis, hematopoiesis, immune function, and most importantly, reproduction. Leptin plays an integral role in the normal physiology of the reproductive system with complex interactions at all levels of the hypothalamic-pituitary gonadal (HPG) axis. In addition, leptin is also produced by placenta, where it plays an important autocrine function. Observational studies have demonstrated that states of leptin excess, deficiency, or resistance can be associated with abnormal reproductive function. This review focuses on the leptin action in female reproduction.

show abstract

Leptin levels in pregnancy, marker for fat accumulation and mobilization?

Abstract: On the basis of these observations, we postulate that plasma leptin levels increase significantly in human pregnancies and that the pattern of change in circulating leptin parallels the process of fat accumulation and mobilization.

Cited by 74 publications

References 8 publications

Increased plasma leptin in gestational diabetes

Increased plasma leptin in gestational diabetes

Leptin and phospholipid-esterified docosahexaenoic acid concentrations in plasma of women: observations during pregnancy and lactation

Role of leptin in female reproduction

Contact Info

Product

Resources

About