Leptin Resistance as a Cause of Lack of Eating Behavior Changes in Hyperleptinemia and Obesity in Female Rats — Offspring of Gestational Stressed Mothers

Abstract

In the experiment on Wistar rats was studied age dynamics of body weight in the postnatal period in the offspring of gestational stressed mothers, which was born with low weight and reduced levels of leptin in the blood plasma. It was shown that adult offspring of stressed mothers have increased body weight and visceral fat mass, increased levels of leptin in the blood compared to the offspring of intact mothers. However, by the number of food consumed offspring of stressed mothers did not differ from intact offspring. Long-term injection of exogenous leptin does not affect the eating behavior of offspring of stressed mothers, although inhibits the eating behavior the intact animals. It was concluded about availability of «economic type» energy metabolism and insulin resistance in the hypothalamic structures of offspring of gestational stressed mothers