Les hépatites B et C chez les donneurs bénévoles de sang et non rémunérés de l’Est de la République démocratique du Congo

Kabinda, Jeff Maotela; Miyanga, Serge Ahuka; Misingi, Pacifique; Ramazani, Sylvain Yuma

doi:10.1016/j.tracli.2014.04.001

Cited by 14 publications

(27 citation statements)

References 12 publications

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“…In our cohort, HBsAg prevalence (22.3%) was higher than that previously reported in asymptomatic blood donors in Kinshasa town and Lubumbashi (more than 9%) (28, 29), Kisangani (5.4%) (30), and Bukavu (4.8%) (25). Although HBV infection often becomes chronic, we revealed a high rate of acute HBV infection based on anti-HBc IgM reactivity (11.0%) along with high HBV DNA levels (82.3%).…”

Section: Discussioncontrasting

confidence: 73%

“…Although acute febrile jaundice strongly suggests infection with hepatitis viruses in medical practice, patients who test negative for yellow fever are never screened for these viruses. Furthermore, viral hepatitis prevalence data in the DRC are either absent (HDV), scarce (HEV) (21), old (HAV) (22), or limited to asymptomatic patients in urban areas (HBV and HCV) (23–25). Little is known about the prevalence and genetic diversity of these viruses in symptomatic patients.…”

Section: Introductionmentioning

confidence: 99%

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High Prevalence and Diversity of Hepatitis Viruses in Suspected Cases of Yellow Fever in the Democratic Republic of Congo

et al. 2017

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The majority of patients with acute febrile jaundice (>95%) identified through a yellow fever surveillance program in the Democratic Republic of Congo (DRC) test negative for antibodies against yellow fever virus. However, no etiological investigation has ever been carried out on these patients. Here, we tested for hepatitis A (HAV), hepatitis B (HBV), hepatitis C (HCV), hepatitis D (HDV), and hepatitis E (HEV) viruses, all of which can cause acute febrile jaundice, in patients included in the yellow fever surveillance program in the DRC. On a total of 498 serum samples collected from suspected cases of yellow fever from January 2003 to January 2012, enzyme-linked immunosorbent assay (ELISA) techniques were used to screen for antibodies against HAV (IgM) and HEV (IgM) and for antigens and antibodies against HBV (HBsAg and anti-hepatitis B core protein [HBc] IgM, respectively), HCV, and HDV. Viral loads and genotypes were determined for HBV and HVD. Viral hepatitis serological markers were diagnosed in 218 (43.7%) patients. The seroprevalences were 16.7% for HAV, 24.6% for HBV, 2.3% for HCV, and 10.4% for HEV, and 26.1% of HBV-positive patients were also infected with HDV. Median viral loads were 4.19 × 105 IU/ml for HBV (range, 769 to 9.82 × 109 IU/ml) and 1.4 × 106 IU/ml for HDV (range, 3.1 × 102 to 2.9 × 108 IU/ml). Genotypes A, E, and D of HBV and genotype 1 of HDV were detected. These high hepatitis prevalence rates highlight the necessity to include screening for hepatitis viruses in the yellow fever surveillance program in the DRC.

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Section: Discussioncontrasting

confidence: 73%

Section: Introductionmentioning

confidence: 99%

High Prevalence and Diversity of Hepatitis Viruses in Suspected Cases of Yellow Fever in the Democratic Republic of Congo

et al. 2017

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“…Females were more represented in both populations; 67.2% in the immunocompetent group and 67.4% in the immunocompromised group [10]. The immunocompetent group was dominant in the surveyed population [11]. Just over half, 54.5%, consisted of new blood donors [11].…”

Section: Resultsmentioning

confidence: 94%

“…The immunocompetent group was dominant in the surveyed population [11]. Just over half, 54.5%, consisted of new blood donors [11]. According to the study, for the city of Bukavu, the profile of the donor at risk is a married male blood donor from rural areas under the age of 30 years [11].…”

Section: Resultsmentioning

confidence: 94%

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Infection with Hepatitis B and C Virus in the Democratic Republic of Congo: A Public Health Problem

Bulanda¹,

Bongenya²,

Kabasele³

et al. 2018

OALib

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Background: Viral hepatitis represents a major public health burden with more than 375 million people with chronic hepatitis B infection and 130 to 150 million with hepatitis C for 2016. Sub-Saharan Africa has the heaviest burden of the epidemic. Objective: The objective of this review is to present the characteristics of hepatitis B and C infections (HBV and HCV), present the synthesis and estimate its magnitude in the Democratic Republic of Congo for the last 20 years. Methods: This work consisted in cataloging the various published articles and abstracts presented in scientific conferences having as subject of interest the infection with viral hepatitis B and C in the DRC.

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Hepatitis B virus infection in the Democratic Republic of Congo: a systematic review of prevalence studies (2000–2016)

Shindano

Kabinda

Mitashi

et al. 2018

J Public Health (Berl.)

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Les hépatites B et C chez les donneurs bénévoles de sang et non rémunérés de l’Est de la République démocratique du Congo

Cited by 14 publications

References 12 publications

High Prevalence and Diversity of Hepatitis Viruses in Suspected Cases of Yellow Fever in the Democratic Republic of Congo

High Prevalence and Diversity of Hepatitis Viruses in Suspected Cases of Yellow Fever in the Democratic Republic of Congo

Infection with Hepatitis B and C Virus in the Democratic Republic of Congo: A Public Health Problem

Hepatitis B virus infection in the Democratic Republic of Congo: a systematic review of prevalence studies (2000–2016)

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