Les liaisons dangereuses: immunological synapse formation in animals and plants

Kwon, Chian; Panstruga, Ralph; Schulze‐Lefert, Paul

doi:10.1016/j.it.2008.01.004

Cited by 42 publications

(26 citation statements)

References 94 publications

(143 reference statements)

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“…In this well-studied system, immune cells such as cytotoxic T cells and Natural Killer cells can deliver suicide orders such as the release of GranzymeB-packaged vesicles, to virus-infected cells. By analogy to these mammalian defense systems, PEN1 is postulated to mediate the release of anti-microbial and possibly cell-wall reinforcing compounds at the site of fungal attack that spare the plant cell from cell death (Kwon et al, 2008b). Delivery of anti-microbial and cell-wall components within specialized vesicles supposedly depend on intact cytoskeleton tracks (see discussion above and Figure 6).…”

Section: Déjà Vu: Rpw8-mediated Defense As a Recurrent Theme In Naturmentioning

confidence: 99%

The Powdery Mildew Disease of Arabidopsis: A Paradigm for the Interaction between Plants and Biotrophic Fungi

Micali

Göllner

Humphry

et al. 2008

The Arabidopsis Book

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101

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The powdery mildew diseases, caused by fungal species of the Erysiphales, have an important economic impact on a variety of plant species and have driven basic and applied research efforts in the field of phytopathology for many years. Although the first taxonomic reports on the Erysiphales date back to the 1850's, advances into the molecular biology of these fungal species have been hampered by their obligate biotrophic nature and difficulties associated with their cultivation and genetic manipulation in the laboratory. The discovery in the 1990's of a few species of powdery mildew fungi that cause disease on Arabidopsis has opened a new chapter in this research field. The great advantages of working with a model plant species have translated into remarkable progress in our understanding of these complex pathogens and their interaction with the plant host. Herein we summarize advances in the study of Arabidopsis-powdery mildew interactions and discuss their implications for the general field of plant pathology. We provide an overview of the life cycle of the pathogens on Arabidopsis and describe the structural and functional changes that occur during infection in the host and fungus in compatible and incompatible interactions, with special emphasis on defense signaling, resistance pathways, and compatibility factors. Finally, we discuss the future of powdery mildew research in anticipation of the sequencing of multiple powdery mildew genomes. The cumulative body of knowledge on powdery mildews of Arabidopsis provides a valuable tool for the study and understanding of disease associated with many other obligate biotrophic pathogen species.

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Section: Déjà Vu: Rpw8-mediated Defense As a Recurrent Theme In Naturmentioning

confidence: 99%

The Powdery Mildew Disease of Arabidopsis: A Paradigm for the Interaction between Plants and Biotrophic Fungi

Micali

Göllner

Humphry

et al. 2008

The Arabidopsis Book

Self Cite

101

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“…MAMP-triggered defense is the first barrier to prevent the invasion of pathogens and plays a major role in the basal resistance of plants against various pathogens. It is also well known that this defense system is strikingly similar to the innate immunity of animals (1,3,4).…”

mentioning

confidence: 94%

Chitin-induced activation of immune signaling by the rice receptor CEBiP relies on a unique sandwich-type dimerization

Hayafune

Berisio

Marchetti

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

291

250

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Perception of microbe-associated molecular patterns (MAMPs) through pattern recognition receptors (PRRs) triggers various defense responses in plants. This MAMP-triggered immunity plays a major role in the plant resistance against various pathogens. To clarify the molecular basis of the specific recognition of chitin oligosaccharides by the rice PRR, CEBiP (chitin-elicitor binding protein), as well as the formation and activation of the receptor complex, biochemical, NMR spectroscopic, and computational studies were performed. Deletion and domain-swapping experiments showed that the central lysine motif in the ectodomain of CEBiP is essential for the binding of chitin oligosaccharides. Epitope mapping by NMR spectroscopy indicated the preferential binding of longer-chain chitin oligosaccharides, such as heptamer-octamer, to CEBiP, and also the importance of N-acetyl groups for the binding. Molecular modeling/docking studies clarified the molecular interaction between CEBiP and chitin oligosaccharides and indicated the importance of Ile 122 in the central lysine motif region for ligand binding, a notion supported by site-directed mutagenesis. Based on these results, it was indicated that two CEBiP molecules simultaneously bind to one chitin oligosaccharide from the opposite side, resulting in the dimerization of CEBiP. The model was further supported by the observations that the addition of (GlcNAc) 8 induced dimerization of the ectodomain of CEBiP in vitro, and the dimerization and (GlcNAc) 8 -induced reactive oxygen generation were also inhibited by a unique oligosaccharide, (GlcNβ1,4GlcNAc) 4 , which is supposed to have N-acetyl groups only on one side of the molecule. Based on these observations, we proposed a hypothetical model for the ligand-induced activation of a receptor complex, involving both CEBiP and Oryza sativa chitinelicitor receptor kinase-1.plant immunity | MTI/PTI | chitin signaling | receptor-ligand interaction |

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“…At least two secretory pathways operate in Arabidopsis disease resistance to non-adapted powdery mildew fungi (Kwon et al, 2008a;2008b). One pathway consists of the P450 monooxygenase CYP81F2, the myrosinase PEN2, and the ABC transporter PEN3.…”

Section: Introductionmentioning

confidence: 99%

Requirement of Vesicle-Associated Membrane Protein 721 and 722 for Sustained Growth during Immune Responses in Arabidopsis

Yun

Kwaaitaal

Kato

et al. 2013

Molecules and Cells

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Extracellular immune responses to ascomycete and oomycete pathogens in Arabidopsis are dependent on vesicle-associated secretion mediated by the SNARE proteins PEN1 syntaxin, SNAP33 and endomembrane-resident VAMP721/722. Continuous movement of functional GFP-VAMP722 to and from the plasma membrane in nonstimulated cells reflects the second proposed function of VAMP721/722 in constitutive secretion during plant growth and development. Application of the bacterium-derived elicitor flg22 stabilizes VAMP721/722 that are otherwise constitutively degraded via the 26S proteasome pathway. Depletion of VAMP721/722 levels by reducing VAMP721/ 722 gene dosage enhances flg22-induced seedling growth inhibition in spite of elevated VAMP721/722 abundance. We therefore propose that plants prioritize the deployment of the corresponding secretory pathway for defense over plant growth. Interstingly, VAMP721/722 specifically interact in vitro and in vivo with the plasma membrane syntaxin SYP132 that is required for plant growth and resistance to bacteria. This suggests that the plant growth/immunityinvolved VAMP721/722 form SNARE complexes with multiple plasma membrane syntaxins to discharge cuedependent cargo molecules.

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Les liaisons dangereuses: immunological synapse formation in animals and plants

Cited by 42 publications

References 94 publications

The Powdery Mildew Disease of Arabidopsis: A Paradigm for the Interaction between Plants and Biotrophic Fungi

The Powdery Mildew Disease of Arabidopsis: A Paradigm for the Interaction between Plants and Biotrophic Fungi

Chitin-induced activation of immune signaling by the rice receptor CEBiP relies on a unique sandwich-type dimerization

Requirement of Vesicle-Associated Membrane Protein 721 and 722 for Sustained Growth during Immune Responses in Arabidopsis

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