Les phtalates dans les dispositifs médicaux destinés à la nutrition artificielle

Bagel, S; Décaudin, Bertrand; Neuville, S.; Chopineau, J.; Odou, Pascal; Sautou, V.

doi:10.1016/j.nupar.2010.11.001

Cited by 7 publications

(2 citation statements)

References 33 publications

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“…D'autres plastiques peuvent être utilisés dans les DM comme le polyéthylène et le polyuréthane, qui sont des plastiques sans plastifiants [41]. Néanmoins la production des DM avec des propriétés techniques comme celles de PVC nécessite un coût élevé [20].…”

Section: Très éLevéunclassified

Risque des phtalates contenus dans les dispositifs médicaux sur la santé des patients

JOUIDA

2023

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Introduction: Medical devices are devices used in the majority of therapies in hospitals. Up to 30% of medical devices are made of plasticized PVC, this plasticization is ensured by phthalates which are the most used plasticizers, but they are also dangerous molecules for human health. Method: Therefore, the objective of this study was to evaluate the risk related to the use in patients of MD based on PVC plasticized by phthalates. To achieve this objective, the MD with phthalates in CHUIS were identified and their risk was evaluated using the equation: Risk = Hazard x Exposure. Results and discussion: In this study we found 15.94% of the MD managed by the CHUIS pharmacy based on plasticized PVC, 47.5% of them were plasticized with phthalates. These MD were classified according to their risk relative to phthalates, 57.9% were of low risk, they are MD used for urine and blood drainage, oxygenation and perfusion. About 10.52% of the MD were medium risk, these MD are in contact with blood and digestive tract. In addition, 26.31% of the high-risk MD, which are all characterized by their contact with blood, which increases their dangerousness. And 5.26% of the very high-risk MD characterized by their prolonged contact with the organism and their contact with cytotoxic drugs. Conclusion: Due to the danger of phthalates to patients, extensive research is needed on this topic.

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Section: Très éLevéunclassified

Risque des phtalates contenus dans les dispositifs médicaux sur la santé des patients

JOUIDA

2023

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“…This type of plasticizer has been brought into question by the results of studies that claim these substances could be harmful after the extraction from the polymer matrix. [37,38] This situation, together with governmental regulatory policies, [39][40][41] led food and pharmaceutical markets of PVC to demand new plasticizers with less aggressive toxicological characteristics for humans. [42] Esters from citric acid, isosorbide, maleic, and trimellitic anhydrides have been tested as potential substitutes of PA esters in PVC formulations for food and pharmaceutical applications.…”

Section: Case Study: Development Of a Polyvinyl Chloride (Pvc) Plasticizer From Glycerolmentioning

confidence: 99%

Chemical product design integrating MCDA: Performance prediction and human preferences modelling

et al. 2021

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Computation-based techniques and modelling of human knowledge and preferences by using multi-criteria decision aid (MCDA) methods are integrated in a multi-scale and multi-disciplinary approach for the chemical product and process design. The proposed methodology has four main stages: (a) construction of a molecular model for predicting product performance, (b) validation of product performance, (c) selection of alternatives integrating preferences of manufacturers and consumers, and (d) process optimization implementing MCDA methods. The methodology is oriented to find new products that can replace components of formulations, whose performance is already known. It was applied to an exploratory study about the use of glycerol as raw material to produce plasticizers for polyvinyl chloride (PVC), replacing 2-ethylhexyl phthalate (DEHP). The results of the case study and the proposed process design offer promising prospects regarding their application in other chemical products.

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Phthalates, non-phthalates, polychlorinated biphenyls, and phenyl phosphates in atmospheric suspended particulate matter of Dhahran City, Saudi Arabia: levels and seasonal variation

Rushdi

Simoneit

Lijotra

et al. 2022

Int. J. Environ. Sci. Technol.

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This work describes the seasonal variations, levels, and possible health effects of groups of persistent organic pollutants (POPs) as phthalates (Ps), non-phthalates (NPs), polychlorinated biphenyls (PCBs), and phenyl phosphates (PhePhs) in ambient total suspended particles (TSP) from the city of Dhahran, Saudi Arabia. The mass concentrations of TSP ranged from 88±32 µg m −3 in winter to 350±320 µg m −3 in summer.The total concentrations of these compounds varied from 337±266 ng m −3 in summer to 469±403 ng m −3 in winter. The major compounds were Ps (235±199 ng m −3 in summer to 389±335 ng m −3 in winter), PCBs (30.7±19.3 ng m −3 in autumn to 65.6±61.2 ng m −3 in summer), NPs (4.9±2.3 ng m −3 in summer to 11.9±12.5 ng m −3 in winter), and PhePhs (4.1±4.0 ng m −3 in spring to 13.3±3.2 ng m −3 in summer). The proportional fractions of these POPs relative to natural biogenic sources and petroleum-related emissions were extremely high ranging from 17% in winter to 47% in autumn. Significant correlations were found among these different POP groups and total concentrations, suggesting that they were from local sources. Principal component analysis indicated that Ps and NPs were from the same initial sources, and the PhePhs as well as PCBs were from different regional sources, where the latter were dependent on the TSP levels. In the long term, the elevated levels of these POPs in the TSP of these urban areas will affect human health by eventually developing a range of illnesses.Recent research has shown that di(2-ethylhexyl) adipate induced developmental toxicity (Dalgaard et al. 2003) and increased ovarian follicle atresia (Miyata et al. 2006). Regional relevanceThere has been an increase in industrial activities and development related to oil production in the eastern province of the Kingdom of Saudi Arabia. There the metropolitan area of Dammam is the largest industrial region of the country, where different petroleum and petrochemical manufacturing corporations and companies have been established in the cities of Dammam, Al-Hasa, and Al-Jubail (El-Sharkawy and Zaki 2012). Plastic manufacturing is one of the main industrial activities in the Dammam area and Al-Jubail in the north as the largest regional industrial complex. The air quality of the region is ultimately affected by these industries and related activities in the area (Salama et al. 2015;Rushdi et al. 2017;El-Sharkawy and Dahlawi 2019). There is a lack of information regarding the compositions, levels, and seasonal variation of POP and petrochemical additives in atmospheric particulate matter of the major cities of the Kingdom and specifically the eastern province of Saudi Arabia.The main purpose of this study is to determine the occurrence, concentration, and seasonal variation of the dominant plastic-related POPs in atmospheric suspended particulate matter in the City of Dhahran, one of the major urban areas in the Dammam metropolitan region. Study areaThis study was conducted in Dhahran (population 99,540), located in the eastern province of Saudi Ara...

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Les phtalates dans les dispositifs médicaux destinés à la nutrition artificielle

Cited by 7 publications

References 33 publications

Risque des phtalates contenus dans les dispositifs médicaux sur la santé des patients

Risque des phtalates contenus dans les dispositifs médicaux sur la santé des patients

Chemical product design integrating MCDA: Performance prediction and human preferences modelling

Phthalates, non-phthalates, polychlorinated biphenyls, and phenyl phosphates in atmospheric suspended particulate matter of Dhahran City, Saudi Arabia: levels and seasonal variation

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