In order to probe modifications of gravity at cosmological scales, one needs accurate theoretical predictions. N-body simulations are required to explore the non-linear regime of structure formation but are very time consuming. In this work, we release a new public emulator, dubbed E-MANTIS, that performs an accurate and fast interpolation between the predictions of f(R) modified gravity cosmological simulations, run with ECOSMOG. We sample a wide 3D parameter space given by the current background scalar field value 10 −7 < f R 0 < 10 −4 , matter density 0.24 < m < 0.39, and primordial power spectrum normalization 0.6 < σ 8 < 1.0, with 110 points sampled from a Latin hypercube. For each model we perform pairs of f(R)CDM and CDM simulations covering an effective volume of 560 h −1 Mpc 3 with a mass resolution of ∼2 × 10 10 h −1 M . We build an emulator for the matter power spectrum boost B(k) = P f(R) (k)/P CDM (k) using a Gaussian process regression method. The boost is mostly independent of h, n s , and b , which reduces the dimensionality of the relevant cosmological parameter space. Additionally, it is more robust against statistical and systematic errors than the raw power spectrum, thus strongly reducing our computational needs. According to our dedicated study of numerical systematics, the resulting emulator has an estimated maximum error of 3 per cent across the whole cosmological parameter space, for scales 0.03 h Mpc −1 < k < 7 h Mpc −1 , and redshifts 0 < z < 2, while in most cases the accuracy is better than 1 per cent. Such an emulator could be used to constrain f(R) gravity with weak lensing analyses.