Les tests de diagnostic rapide en biochimie médicale : intérêts, limites et dangers

Baudin, Bruno

doi:10.1016/s1773-035x(15)30247-1

Revue Francophone des Laboratoires

2015

DOI: 10.1016/s1773-035x(15)30247-1

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Les tests de diagnostic rapide en biochimie médicale : intérêts, limites et dangers

Bruno Baudin

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2018

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Cited by 2 publications

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Interests in the use of Rapid Prostate Antigen Screening Test in the North-Cameroon

et al. 2018

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Introduction: The number of prostate cancer detected late because of the lack of means of investigation allowing a proximity screening, the poverty which characterize north are the two main elements which led us to lead this study which had for objective to shown the value of using rapid PSA screening tests. Method: We conducted a cross-sectional analytical study in the city of Ngaoundere and Garoua for a period of 5 months. Results: A total of 220 PSA level assays were performed over the 5-month period of our study with variations between the two selected centers. Of 30 samples used to study the sensitivity of rapid PSA screening tests, 22 were positive and 8 negative. The concordance rate for the positive values of the rapid test strip test versus the assay was 100%. The concordance of negative values was 87.5%. In addition, in a sample of 41 patients, PSA tests were performed in 30 patients, or 73.17%, and diagnosed prostate cancer in 69.23% of diagnosed cancer cases. Conclusion: Rapid PSA screening tests are good tools for diagnosing prostate cancer when combined with other tools such as digital rectal examination and ultrasound.

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Interests in the use of Rapid Prostate Antigen Screening Test in the North-Cameroon

et al. 2018

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Hyperglycosylated hCG and Its Free ß-Subunit Drives Malignancy

Cole

2018

J. Anal. Oncol.

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Tumor marker studies were conducted measuring 2,277 malignancies using a cut-off of 3 fmol/ml. As found 110 of 110 trophoblastic malignancies or 100% were positive for ß-core fragment an hCG serum degradation product. Just 949 of 2167 (44%) of non-trophoblastic or other cancers were positive using this 3 fmol/ml cut-off. When the cut-off of the assay was lowered to 0.1 fmol/ml, or lowered by 30-fold 100% of non-trophoblastic or other cancers were detected, or all cancers were detected. What do cancers secrete. Cancer were tested with three immunoassays, Immulite total hCG, B152 hyperglycosylated hCG and FBT11 free ß-subunit, serum of 34 trophoblastic cancers and 32 non-trophoblastic cancers were tested. A total of 34 of 34 trophoblastic cancer produced primarily hyperglycosylated hCG (B152 hyperglycosylated assay 96%±12% of Immulite), and 32 of 32 non-trophoblastic cancers produced primarily hyperglycosylated hCG free ß-subunit (B152 hyperglycosylated assay 102%±6.2% of Immulite, FBT11 free ß-subunit assay 128%±10% of Immulite). Seven independent laboratories each showed with a wide mixture of cancers (patient tissue and cancer cell lines) that ß-subunit promoted malignancy (cell growth, cell invasion and blockage of apoptosis) in cancer cells. I then showed that hyperglycosylated hCG and its ß-subunit promoted malignancy in 10 different cancer cell lines. I then tied my data and the seven independent laboratory data together and concluded that hyperglycosylated hCG and its ß-subunit drove malignancy in all or most cancers.

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Les tests de diagnostic rapide en biochimie médicale : intérêts, limites et dangers

Cited by 2 publications

References 7 publications

Interests in the use of Rapid Prostate Antigen Screening Test in the North-Cameroon

Interests in the use of Rapid Prostate Antigen Screening Test in the North-Cameroon

Hyperglycosylated hCG and Its Free ß-Subunit Drives Malignancy

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