Les urticaires de contact

Tremeau-Martinage, C.; Giordano‐Labadie, F.; Bazex, J

doi:10.1016/s0335-7457(95)80025-5

Cited by 6 publications

(1 citation statement)

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“…The Dsg autoantibodies are of the IgG class and in active PV are predominantly IgG4 polyclonal antibodies but IgG1 while in remission Tremeau-Martinage et al, 1995). Dsg 1 autoantibodies are found in over 50% of cases of PV, and the frequency may differ with race, since they are found in a significantly greater proportion of patients of Indian origin than in white northern Europeans (Harman et al, 2000b).…”

Section: Pathogenesismentioning

confidence: 99%

Pemphigus Vulgaris: Update on Etiopathogenesis, Oral Manifestations, and Management

Scully

Challacombe

2002

Critical Reviews in Oral Biology & Medicine

139

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ABSTRACT:Pemphigus is a group of potentially life-threatening diseases characterized by cutaneous and mucosal blistering. There is a fairly strong genetic background to pemphigus with linkage to HLA class II alleles. Certain ethnic groups, such as Ashkenazi Jews and those of Mediterranean origin, are especially liable to pemphigus. Pemphigus vulgaris (PV), the most common and important variant, is an autoimmune blistering disease characterized by circulating pathogenic IgG antibodies against desmoglein 3 (Dsg3), about half the patients also having Dsg1 autoantibodies. Oral lesions are initially vesiculobullous but readily rupture, new bullae developing as the older ones rupture and ulcerate. Biopsy of perilesional tissue, with histological and immunostaining examinations, is essential to the diagnosis. Serum autoantibodies to either Dsg1 or Dsg3 are best detected by both normal human skin and monkey esophagus or by enzyme-linked immunosorbent assay (ELISA). Before the introduction of corticosteroids, pemphigus vulgaris was typically fatal mainly from dehydration or secondary systemic infections. Current treatment is largely based on systemic immunosuppression using systemic corticosteroids, with azathioprine, dapsone, methotrexate, cyclophosphamide, and gold as adjuvants or alternatives, but mycophenolate mofetil and intravenous immunoglobulins also appear promising.

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Section: Pathogenesismentioning

confidence: 99%