Lesional T‐cell subset in leprosy and leprosy reaction

Mahaisavariya, Punkae; Kulthanan, Kanokvalai; Khemngern, Supakan; Pinkaew, Sumruay

doi:10.1046/j.1365-4362.1999.00621.x

Cited by 14 publications

(9 citation statements)

References 4 publications

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“…The in situ characterization of T-cell subsets in lesional tissue has been widely studied in conditions such as leprosy and American cutaneous leishmaniasis. [3][4][5][6] To the best of our knowledge, no study has characterized the inflammatory infiltrate in lesions of PKDL. In this study, there was a preponderance of T-suppressor cells in both types of lesions.…”

Section: Discussionmentioning

confidence: 99%

Lesional T‐cell subset in post‐kala‐azar dermal leishmaniasis

Rathi¹,

Pandhi²,

Chopra³

et al. 2004

Int J Dermatology

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Background The pathogenesis of post-kala-azar dermal leishmaniasis (PKDL) is ill understood. This study was carried out to find the percentage of T-helper and T-suppressor cells in lesional tissue and their probable role in the pathogenesis of PKDL.Methods An immunoperoxidase monoclonal antibody technique was used to characterize and quantify the subsets of T lymphocytes in the infiltrate in 25 patients with PKDL. ResultsThe ratio of T-helper to T-suppressor cells was 0.87 in hypopigmented macules and 0.85 in nodule and /or plaque lesions of PKDL. ConclusionsIn this study, there was a definite preponderance of T-suppressor cells over T-helper cells in both types of skin lesions of PKDL. Further studies should be undertaken on larger numbers of patients to compare T-cell subsets both in skin lesions and the circulation, in order to determine the pathogenesis of PKDL.

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Section: Discussionmentioning

confidence: 99%

Lesional T‐cell subset in post‐kala‐azar dermal leishmaniasis

Rathi¹,

Pandhi²,

Chopra³

et al. 2004

Int J Dermatology

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“…ENL skin lesions, like peripheral blood, were characterized by an increased CD4 + /CD8 + ratio in all but one of these studies (89, 91, 97–100, 102, 103). …”

Section: What Is the Role Of T-cells In Enl?mentioning

confidence: 88%

“…The first immunohistological studies of T-cell subsets in skin lesions included small numbers of ENL patients and assessed the percentage and ratio of CD4 + and CD8 + T cells by comparing them to non-ENL lepromatous specimens (89, 91, 97–103). ENL skin lesions, like peripheral blood, were characterized by an increased CD4 + /CD8 + ratio in all but one of these studies (89, 91, 97–100, 102, 103).…”

Section: What Is the Role Of T-cells In Enl?mentioning

confidence: 99%

A Systematic Review of Immunological Studies of Erythema Nodosum Leprosum

2017

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Erythema nodosum leprosum (ENL) is a painful inflammatory complication of leprosy occurring in 50% of lepromatous leprosy patients and 5–10% of borderline lepromatous patients. It is a significant cause of economic hardship, morbidity and mortality in leprosy patients. Our understanding of the causes of ENL is limited. We performed a systematic review of the published literature and critically evaluated the evidence for the role of neutrophils, immune complexes (ICs), T-cells, cytokines, and other immunological factors that could contribute to the development of ENL. Searches of the literature were performed in PubMed. Studies, independent of published date, using samples from patients with ENL were included. The search revealed more than 20,000 articles of which 146 eligible studies were included in this systematic review. The studies demonstrate that ENL may be associated with a neutrophilic infiltrate, but it is not clear whether it is an IC-mediated process or that the presence of ICs is an epiphenomenon. Increased levels of tumor necrosis factor-α and other pro-inflammatory cytokines support the role of this cytokine in the inflammatory phase of ENL but not necessarily the initiation. T-cell subsets appear to be important in ENL since multiple studies report an increased CD4+/CD8+ ratio in both skin and peripheral blood of patients with ENL. Microarray data have identified new molecules and whole pathophysiological pathways associated with ENL and provides new insights into the pathogenesis of ENL. Studies of ENL are often difficult to compare due to a lack of case definitions, treatment status, and timing of sampling as well as the use of different laboratory techniques. A standardized approach to some of these issues would be useful. ENL appears to be a complex interaction of various aspects of the immune system. Rigorous clinical descriptions of well-defined cohorts of patients and a systems biology approach using available technologies such as genomics, epigenomics, transcriptomics, and proteomics could yield greater understanding of the condition.

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“…The decrease in mast cell density in leprosy reactions correlates with the decrease in CD8+ T cells in our previous study on lesion T‐cell subsets in leprosy and leprosy reactions. 16 Wallach et al . 17 found that peripheral blood T‐suppressor cells were transiently decreased in erythema nodosum leprosum.…”

Section: Discussionmentioning

confidence: 99%