Less blood loss under concomitant administration of tranexamic acid and indirect factor Xa inhibitor following total knee arthroplasty: a prospective randomized controlled trial

Lee, Sang Hak; Cho, Kye-Youl; Khurana, Sumit; Kim, Kang‐Il

doi:10.1007/s00167-012-2213-1

Cited by 46 publications

(45 citation statements)

References 42 publications

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“…The above stated results are comparable with studies by charoencholvanich et al [17] , Gautam et al [18] and Lee et al [19] . These authors used similar dose regimen protocols as was used in this study.…”

Section: Blood Transfusionsupporting

confidence: 92%

Role of intravenous tranexamic acid for the reduction of blood loss in total knee arthroplasty

Chaudhary¹,

Kumar²,

Mehrotra³

et al. 2017

Int. J. Orthop. Sci.

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Antifibrinolytic drug Tranexamic acid (TXA) administered intravenously has shown to significantly reduced the blood loss intraoperatively (P<0.01) and postoperatively (P<0.01) in patients undergoing bilateral total knee arthroplasty. Two groups of 50 patients each with similar demographic and health profile were selected to undergo this study. One group received the IV Tranexamic Acid (TXA group) while the control group did not received. To avoid complications associated with antifibrinolytic property of tranexamic acid. Strict patient selection criteria and dose regiment protocols were adhered to prevent hypercoagulable state with potential risk of DVT and renal Failure.

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Section: Blood Transfusionsupporting

confidence: 92%

Role of intravenous tranexamic acid for the reduction of blood loss in total knee arthroplasty

Chaudhary¹,

Kumar²,

Mehrotra³

et al. 2017

Int. J. Orthop. Sci.

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“…3 Without any effective thromboprophylaxis, the reported incidence of DVT after THA was 42% to 57%. 3 Considering the complications of DVT prophylaxis such as bleeding, deep inflammation, and prolonged wound drainage, 4,5 searching for some biomarkers that may predict DVT risk after THA will largely help individualized DVT prophylaxis with less complications in ONFH patients.…”

mentioning

confidence: 99%

Higher Levels of Serum Triglycerides Were Associated With Postoperative Deep Vein Thrombosis After Total Hip Arthroplasty in Patients With Nontraumatic Osteonecrosis of the Femoral Head

Dai

Yao

Shi

et al. 2015

The International Journal of Lower Extremity Wounds

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This retrospective study aimed to evaluate the association of serum lipids and deep vein thrombosis (DVT) risk following total hip arthroplasty (THA) in patients with nontraumatic osteonecrosis of the femoral head (ONFH). A total of 224 nontraumatic ONFH patients were enrolled. Serum levels of triglycerides (TG), total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol were detected preoperatively. All the patients underwent unilateral lower extremity venography on postoperative days 3 to 5 for DVT screening. In females, patients who were venogram positive for DVT had a higher serum TG level than those who were venogram negative for DVT (P = .029) and a higher TG level was associated with an increased DVT risk (P = .042). Serum TG levels considerably affect DVT risk after THA in female nontraumatic ONFH patients.

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“…In our study, similar to the studies in the literature. [31][32][33][34][35] It was found that the mean amount drain output & blood loss were 293 ml & 368 ml respectively in TXA Group however 20% of the patients were given PRBC transfusion. In Control Group mean amount of drain output & total blood loss calculated were 446 & 946 respectively, 56% patients required PRBC transfusion.…”

Section: Discussionmentioning

confidence: 99%

Effect of intravenous tranexamic acid on blood loss and blood transfusion in total knee replacement: a prospective, randomized study in Indian population

Kerakkanavar

Venkatesh

et al. 2017

Int J Res Orthop

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Background: Tranexamic acid (TXA) is antifibrinolytic drug which has the property to reduce intraoperative and postoperative bleeding. There are several studies supporting the use of tranexamic acid in total knee replacements (TKR) and few in total hip replacements. Our study was intended to establish the effects of tranexamic acid in minimizing the intra operative and post-operative blood loss in uncomplicated primary total knee replacement.Methods: This was a prospective follow up study conducted in Rajarajeshwari Medical College and Hospital Bangalore, over a period of 14 months from June 2015 to August 2016. A total number of 60 patients who underwent unilateral primary total knee replacement were included for this study. They were randomly divided into 2 groups. Group I patients infused (intravenous) with 20 mg/kg TXA before incision and 3 hours after surgery whereas no TXA was administered in Group II. Total blood loss and transfusion rate were used as outcome. Results: Mean amounts of blood loss were 578 ml in Group 1 and 946 ml in Group 2. There was a decrease in blood loss in TXA groups (p<0.001). Transfusion was required in 6 patients of Group I and 17 patients of Group II (p<0.001). No thromboembolic problem was seen in any patients.Conclusions: Since TXA decrease perioperative blood loss and lessen the need for blood transfusion significantly, without increasing thromboembolic events in TKR. We suggest using intravenous (IV) TXA in TKR.

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Less blood loss under concomitant administration of tranexamic acid and indirect factor Xa inhibitor following total knee arthroplasty: a prospective randomized controlled trial

Cited by 46 publications

References 42 publications

Role of intravenous tranexamic acid for the reduction of blood loss in total knee arthroplasty

Role of intravenous tranexamic acid for the reduction of blood loss in total knee arthroplasty

Higher Levels of Serum Triglycerides Were Associated With Postoperative Deep Vein Thrombosis After Total Hip Arthroplasty in Patients With Nontraumatic Osteonecrosis of the Femoral Head

Effect of intravenous tranexamic acid on blood loss and blood transfusion in total knee replacement: a prospective, randomized study in Indian population

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