Lessons from SARS‑CoV‑2 and its variants (Review)

Qin, Ziwen; Sun, Yan; Zhang, Jian; Zhou, Ling; Chen, Yujuan; Huang, Chuanjun

doi:10.3892/mmr.2022.12779

Cited by 7 publications

(5 citation statements)

References 229 publications

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“…Coronavirus disease 2019 (COVID-19) was identified in January 2020 and since this time has been the cause of global human-to-human transmission ( 1 , 2 ). Five variants of concern (VOC) have been identified so far, namely Alpha, Beta, Gamma, Delta, and Omicron as designated by the World Health Organization (WHO) ( 3 , 4 ).…”

Section: Introductionmentioning

confidence: 99%

Factors associated with prolonged viral shedding in older patients infected with Omicron BA.2.2

Zhong

Yang

Jiang

et al. 2023

Front. Public Health

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BackgroundThis study explores the risk factors associated with viral shedding time in elderly Chinese patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) omicron.MethodsParticipants infected with SARS-CoV-2 omicron were enrolled in a retrospective study, and divided into two groups according to shedding time (≥10 days, “late clearance group” and <10 days, “early clearance group”).ResultsA total of 180 patients were enrolled in the study (88 early, 92 late), with a median viral shedding time of 10 days and a mean age of 77.02 years. Prolonged SARS-CoV-2 omicron shedding was associated with old age (p = 0.007), lack of vaccination (p = 0.001), delayed admission to hospital after onset of diagnosis (p = 0.001), D-dimer (p = 0.003), and methylprednisolone treatment (p = 0.048). In multivariate analysis, vaccination (OR, 0.319, 95% CI, 0.130–0.786, p = 0.013), Paxlovid (OR, 0.259, 95% CI, 0.104–0.643, p = 0.004), and time from onset of diagnosis to admission (OR, 1.802, 95% CI, 1.391–2.355, p = 0.000) were significantly associated with viral clearance.ConclusionsTime from onset of diagnosis to hospitalization, lack of treatment with Paxlovid, and lack of vaccination were independent risk factors in elderly Chinese patients infected with SARS-CoV-2 omicron for prolonged viral shedding.

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Section: Introductionmentioning

confidence: 99%

Factors associated with prolonged viral shedding in older patients infected with Omicron BA.2.2

Zhong

Yang

Jiang

et al. 2023

Front. Public Health

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“…Similar to previous studies, our ICU patients had higher admission clinical severity and CT scores than ward patients. In addition, both ICU and ward patients had pronounced lymphopenia, increased D-dimer, ferritin, hs-CRP, IL-6 levels, and LDH activity [ 25 , 26 ]. In accordance with other studies, LDH had predictive value regarding disease severity, organ failure, and mortality of COVID-19 patients [ 27 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

Serum Total Antioxidant Capacity (TAC) and TAC/Lymphocyte Ratio as Promising Predictive Markers in COVID-19

Horváth-Szalai,

Jakabfi-Csepregi,

Szirmay

et al. 2023

IJMS

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SARS-CoV-2 infection might cause a critical disease, and patients’ follow-up is based on multiple parameters. Oxidative stress is one of the key factors in the pathogenesis of COVID-19 suggesting that its level could be a prognostic marker. Therefore, we elucidated the predictive value of the serum non-enzymatic total antioxidant capacity (TAC) and that of the newly introduced TAC/lymphocyte ratio in COVID-19. We included 61 COVID-19 (n = 27 ward, n = 34 intensive care unit, ICU) patients and 29 controls in our study. Serum TAC on admission was measured by an enhanced chemiluminescence (ECL) microplate assay previously validated by our research group. TAC levels were higher (p < 0.01) in ICU (median: 407.88 µmol/L) than in ward patients (315.44 µmol/L) and controls (296.60 µmol/L). Besides the classical parameters, both the TAC/lymphocyte ratio and TAC had significant predictive values regarding the severity (AUC-ROC for the TAC/lymphocyte ratio: 0.811; for TAC: 0.728) and acute kidney injury (AUC-ROC for the TAC/lymphocyte ratio: 0.747; for TAC: 0.733) in COVID-19. Moreover, the TAC/lymphocyte ratio had significant predictive value regarding mortality (AUC-ROC: 0.752). Serum TAC and the TAC/lymphocyte ratio might offer valuable information regarding the severity of COVID-19. TAC measured by our ECL microplate assay serves as a promising marker for the prediction of systemic inflammatory diseases.

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“…COVID-19 is a complex, severe acute respiratory syndrome caused by the SARS-CoV-2 virus . The rapid spread of the coronavirus and its variants still poses a threat worldwide . Vaccines have brought us hope, resulting in a decline in the risk of disease-related infections .…”

Section: Introductionmentioning

confidence: 99%

“…1 The rapid spread of the coronavirus and its variants still poses a threat worldwide. 2 Vaccines have brought us hope, resulting in a decline in the risk of disease-related infections. 3 However, the virus undergoes mutations, 4 thereby affecting its properties and making it more aggressive and/or increasing the rate of transmissibility, which may affect the efficiency of neutralizing antibodies.…”

Section: Introductionmentioning

confidence: 99%

Antiviral and Nontoxic Dermal Iron Oxide Nanoparticle/Biopolymer Coatings for Cotton Fabric

Constantino,

Mesquita,

Moraes Segundo

et al. 2024

ACS Appl. Nano Mater.

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Lessons from SARS‑CoV‑2 and its variants (Review)

Cited by 7 publications

References 229 publications

Factors associated with prolonged viral shedding in older patients infected with Omicron BA.2.2

Factors associated with prolonged viral shedding in older patients infected with Omicron BA.2.2

Serum Total Antioxidant Capacity (TAC) and TAC/Lymphocyte Ratio as Promising Predictive Markers in COVID-19

Antiviral and Nontoxic Dermal Iron Oxide Nanoparticle/Biopolymer Coatings for Cotton Fabric

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