Lessons Learned during Dengue Outbreaks in the United States, 2001–2011

Adalja, Amesh A.; Sell, Tara Kirk; Bouri, Nidhi; Franco, Crystal

doi:10.3201/eid1804.110968

Cited by 113 publications

(99 citation statements)

References 7 publications

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“…9 Although most cases occur in the endemic areas of the Americas, Southeast Asia, and the Pacific, dengue is a threat to the continental United States; dengue cases are diagnosed each year in travelers returning from endemic areas and autochthonous cases have been documented in Texas and recently also in Florida. [10][11][12][13] New and more effective tools and approaches for surveillance and control of dengue are sorely needed. 14 In the absence of a vaccine, dengue prevention is focused upon controlling mosquito vectors.…”

Section: Introductionmentioning

confidence: 99%

Detection of Dengue Virus NS1 Antigen in Infected Aedes aegypti Using a Commercially Available Kit

Voge¹,

Sánchez-Vargas²,

Blair³

et al. 2013

The American Society of Tropical Medicine and Hygiene

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Abstract. Epidemic dengue has emerged throughout the tropical world. In the continued absence of a vaccine against dengue virus (DENV), mosquito vector surveillance and control programs are essential to reduce human infections. An effective test to detect DENV in infected mosquitoes would be a valuable addition to the surveillance effort. We investigated DENV detection in infected Aedes aegypti using a commercially available DENV non-structural protein 1 (NS1) ELISA kit (Platelia Dengue NS1 Ag), and by reverse transcription-polymerase chain reaction (RT-PCR) and virus isolation assays. The DENV-infected mosquitoes were subjected to field-relevant conditions and assayed individually and pooled with uninfected mosquitoes. Overall, DENV NS1 antigen was detected in 98% of infected mosquitoes/ pools versus 79% for RT-PCR and 29% for virus isolation. Our results indicate that NS1 is an excellent analyte for detection of DENV in Ae. aegypti and that the tested NS1 antigen kit provides a sensitive, rapid, and convenient test for DENV surveillance in mosquitoes.

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Section: Introductionmentioning

confidence: 99%

Detection of Dengue Virus NS1 Antigen in Infected Aedes aegypti Using a Commercially Available Kit

Voge¹,

Sánchez-Vargas²,

Blair³

et al. 2013

The American Society of Tropical Medicine and Hygiene

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“…Furthermore, air travel between dengue-endemic countries and from dengue-endemic to non-endemic vulnerable settings has increased exponentially [36]. Whilst imported dengue cases to the US have resulted in small dengue clusters for many years [37], the first sporadic autochthonous cases in Europe (France and Croatia) were reported in 2010 [38,39]. In 2012, the first major European outbreak of dengue occurred in Madeira [40].…”

Section: Research Areamentioning

confidence: 99%

Novel tools for the surveillance and control of dengue: findings by the DengueTools research consortium

Wilder‐Smith

Tissera

AbuBakar

et al. 2018

Global Health Action

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Background: Dengue fever persists as a major global disease burden, and may increase as a consequence of climate change. Along with other measures, research actions to improve diagnosis, surveillance, prevention, and predictive models are highly relevant. The European Commission funded the DengueTools consortium to lead a major initiative in these areas, and this review synthesises the outputs and findings of this work conducted from 2011 to 2016. Research areas: DengueTools organised its work into three research areas, namely [1] Early warning and surveillance systems; [2] Strategies to prevent dengue in children; and [3] Predictive models for the global spread of dengue.Research area 1 focused on case-studies undertaken in Sri Lanka, including developing laboratory-based sentinel surveillance, evaluating economic impact, identifying drivers of transmission intensity, evaluating outbreak prediction capacity and developing diagnostic capacity. Research area 2 addressed preventing dengue transmission in school children, with case-studies undertaken in Thailand. Insecticide-treated school uniforms represented an intriguing potential approach, with some encouraging results, but which were overshadowed by a lack of persistence of insecticide on the uniforms with repeated washing. Research area 3 evaluated potential global spread of dengue, particularly into dengue-naïve areas such as Europe. The role of international travel, changing boundaries of vectors, developing models of vectorial capacity under different climate change scenarios and strategies for vector control in outbreaks was all evaluated. Concluding remarks: DengueTools was able to make significant advances in methods for understanding and controlling dengue transmission in a range of settings. These will have implications for public health agendas to counteract dengue, including vaccination programmes. Outlook: Towards the end of the DengueTools project, Zika virus emerged as an unexpected epidemic in the central and southern America. Given the similarities between the dengue and Zika viruses, with vectors in common, some of the DengueTools thinking translated readily into the Zika situation.

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“…Global collaboration is the most important in managing & controlling dengue epidemic which are imported from endemic countries to non-endemic areas (Adalja et al, 2012;Effler et al, 2005). There is under reporting and misclassification of lot of dengue cases.…”

Section: Issn: 2319-7706 Volume 7 Number 08 (2018)mentioning

confidence: 99%

Trend in Sero-Prevalence of Dengue Infection in Rural Kerala

Rajesh¹,

Vani²,

Faisal³

et al. 2018

Int.J.Curr.Microbiol.App.Sci

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Lessons Learned during Dengue Outbreaks in the United States, 2001–2011

Abstract: Public health authorities should involve the clinical and laboratory community and engage the local community in vector control and case reporting.

Cited by 113 publications

References 7 publications

Detection of Dengue Virus NS1 Antigen in Infected Aedes aegypti Using a Commercially Available Kit

Detection of Dengue Virus NS1 Antigen in Infected Aedes aegypti Using a Commercially Available Kit

Novel tools for the surveillance and control of dengue: findings by the DengueTools research consortium

Trend in Sero-Prevalence of Dengue Infection in Rural Kerala

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