2024
DOI: 10.1002/mp.17337
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LET‐based approximation of the microdosimetric kinetic model for proton radiotherapy

Alessio Parisi,
Keith M. Furutani,
Tatsuhiko Sato
et al.

Abstract: BackgroundPhenomenological relative biological effectiveness (RBE) models for proton therapy, based on the dose‐averaged linear energy transfer (LET), have been developed to address the apparent RBE increase towards the end of the proton range. The results of these phenomenological models substantially differ due to varying empirical assumptions and fitting functions. In contrast, more theory‐based approaches are used in carbon ion radiotherapy, such as the microdosimetric kinetic model (MKM). However, impleme… Show more

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