1986
DOI: 10.2307/3576798
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Lethal and Potentially Lethal Lesions Induced by Radiation --- A Unified Repair Model

Abstract: A model of radiation action is described which unifies several of the major existing concepts which have been applied to cell killing. Called the

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Cited by 438 publications
(222 citation statements)
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“…This model has been interpreted in different ways, e.g. by the theory of dual radiation action by Kellerer & Rossi (18), and by the low dose approximation of the LPL-model by Curtis (19).…”
mentioning
confidence: 99%
“…This model has been interpreted in different ways, e.g. by the theory of dual radiation action by Kellerer & Rossi (18), and by the low dose approximation of the LPL-model by Curtis (19).…”
mentioning
confidence: 99%
“…Several models have been proposed to account for the process of recovery, including the incomplete repair model [5], the lethal-potentially-lethal model [6] or the repairable-conditionally repairable damage model [7], with the incomplete repair model, based itself on the LQ formalism, being mostly known and employed in clinical practice. According to the incomplete repair model [5], the effect of continuous irradiation delivering radiation dose D in time t is given by equation 1.…”
Section: Repairmentioning
confidence: 99%
“…The surviving fraction (SF) expressed as a function of dose (D) curves were fitted using IgorPro software using the linear quadratic (LQ) model where α [Gy -1 ] and β [Gy -2 ] are the radiosentivity parameters (Chadwick et al 1973;Curtis 1986;Fertil et al 1981;.…”
Section: Clonogenic Survivalmentioning
confidence: 99%