1976
DOI: 10.1128/jb.125.2.643-654.1976
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Lethal effect of mitomycin C on Haemophilus influenzae

Abstract: The sensitivity of ultraviolet-sensitive strains to inactivation by mitomycin C (MC) is at the most only a factor of two greater than that of the wild type. The presence of inducible prophage has very little effect on the sensitivity. Genes which control excision of ultraviolet-induced pyrimidine dimers also control repair of MC-induced cross-links, as measured by resistance of denatured deoxyribonucleic acid (DNA) from treated cells to S1 nuclease digestion. However, endonucleolytic breaks in MC-damaged DNA, … Show more

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Cited by 26 publications
(12 citation statements)
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“…Also shown on the figure as dashed lines are the corresponding curves for the wild-type strain Rd . The wild-type strain is more resistant to both agents, and the difference between mutants and wild type is greater in the case of UV, as previously noted (18).…”
Section: Sensitivity Ofsupporting
confidence: 71%
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“…Also shown on the figure as dashed lines are the corresponding curves for the wild-type strain Rd . The wild-type strain is more resistant to both agents, and the difference between mutants and wild type is greater in the case of UV, as previously noted (18).…”
Section: Sensitivity Ofsupporting
confidence: 71%
“…UV and mitomycin C. Exponentially growing cells were treated with UV radiation and 0.5 gg of mitomycin C per ml as previously described (17,18).…”
mentioning
confidence: 99%
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“…Because the results do not show convincingly that the slopes of the UV and MMS survival curves of the JK57 mutant are steeper than those of the wild type, it is doubtful whether the ATP-dependent DNase is at all involved in DNA repair. The JK57 cells may be more sensitive to MC than wild-type cells because of increased permeability to this compound (21).…”
Section: Discussionmentioning
confidence: 99%
“…The library was selected and maintained in H. influenzae strains BC200 and rec-1. UV irradiation was carried out as described previously (12), except two strains whose sensitivities were to be compared were irradiated together, and survivors could be distinguished by their different antibiotic sensitivities (14). This method is particularly useful for the comparison of sensitivities that are not markedly different.…”
mentioning
confidence: 99%