Lethal hepatic infarction following plasma exchange in living donor liver transplant patients

Mizuno, Shugo; Wada, Hideo; Hamada, Takashi; Nobuoka, Yu; Tabata, Masami; Isaji, Shuji

doi:10.1111/j.1432-2277.2011.01244.x

Cited by 4 publications

(1 citation statement)

References 8 publications

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“…Although a fatal outcome occurred in a severe PVT patient who received an LDLT [60], excellent survival rates were reported in patients with PVT who underwent LDLT [59]. In another study, 68 (2.9%) of 2402 patients who underwent LDLT had PVT and those patients with PVT were found to have a worse prognosis than those without PVT [61].…”

Section: Activation and Consumption Of Platelets Due To Thrombosismentioning

confidence: 99%

Platelets Activation and Liver Transplantation

Usui¹,

Wada²,

Mizuno³

et al. 2017

J Liver

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Transient thrombocytopenia is a common phenomenon after living donor liver transplantation (LDLT), and severe thrombocytopenia after LDLT is associated with graft loss and poor patient outcomes. The various causes of thrombocytopenia include bone marrow hematopoiesis failure due to decreased thrombopoietin (TPO) production in the injured liver, platelet destruction associated with splenomegaly, and the activation and consumption of platelets due to various forms of thrombosis, including disseminated intravascular coagulation (DIC), thrombotic microangiopathy (TMA), and venous thromboembolism (VTE).The observation of biomarkers such as soluble platelet glycoprotein VI (sGPVI), TPO, von Willebrand factor (VWF), VWF propeptide (VWFpp), and disintegrin-like and metalloproteinase with thrombospondin type-1 motifs member 13 (ADAMTS13) is useful in the evaluation of the mechanisms of thrombocytopenia in patients who undergo LDLT. The presence of these biomarkers, including sGPVI, ADAMTS13, VWF and VWFpp, suggests that platelet activation occurs in the early phase of LDLT and that vascular endothelial cell injury occurs on postoperative days 7-14.

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Section: Activation and Consumption Of Platelets Due To Thrombosismentioning

confidence: 99%

Platelets Activation and Liver Transplantation

Usui¹,

Wada²,

Mizuno³

et al. 2017

J Liver

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Prolonged thrombocytopenia after living donor liver transplantation is a strong prognostic predictor irrespective of history of splenectomy: the significance of ADAMTS13 and graft function

et al. 2014

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The precise mechanism of prolonged thrombocytopenia following living donor liver transplantation (LDLT) remains unclear. To determine risk factors associated with prolonged thrombocytopenia following LDLT, with a focus on the activity of ADAMTS13 (a disintegrin-like and metalloproteinase with thrombospondin type-1 motifs member 13) and the influence of splenectomy. Adult LDLT patients were divided into two groups on the basis of platelet counts (100 × 10(3)/μL) on POD 14: high and low platelet (HP and LP) groups. Survival analysis was performed in the 100 patients, and ADAMTS13 activity and von Willebrand factor (VWF) levels in the plasma were measured in 65 adult recipients. The 6-month survival rate was significantly lower in the LP group (n = 36) than in the HP group (n = 62) (61.1 vs. 93.5 %). ADAMTS13 activity had been significantly lower in the LP group (n = 23) than in the HP group (n = 42). The VWF/ADAMTS13 ratio was significantly higher in the LP group than in the HP group. The independent risk factors for thrombocytopenia on POD14 were preoperative AT levels and ADAMTS13 activity on POD14. TPO levels on POD14 were significantly higher in the LP group than in the HP group, while those on POD28 in the LP group were significantly decreased, despite the low platelet levels. Irrespective of splenectomy, platelet counts and ADAMTS13 activity in the LP group remained low until POD28, while VWF/ADAMTS13 ratio significantly increased until POD28. These results suggest that prolonged thrombocytopenia after LDLT was associated with not only a decrease in ADAMTS13 due to sinusoidal endothelial cell injury, but also low TPO production due to hepatocyte dysfunction, irrespective of splenectomy [corrected].

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Erratum to: Prolonged thrombocytopenia after living donor liver transplantation is a strong prognostic predictor irrespective of history of splenectomy: the significance of ADAMTS13 and graft function

et al. 2016

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production due to hepatocyte dysfunction, irrespective of splenectomy."Errors have subsequently been identified in the original publication, and the following corrections should be noted: The author would like to correct the errors in the publication of the original article. The corrected details are given below for your reading. The original article was published with the incorrect title. The correct title should read: "Prolonged thrombocytopenia after living donor liver transplantation is a strong prognostic predictor irrespective of splenectomy: the significance of ADAMTS13 and graft function".Secondly, the last two sentences beneath the heading "Abstract" should read as "Irrespective of splenectomy, platelet counts and ADAMTS13 activity in the LP group remained low until POD28, while VWF/ADAMTS13 ratio significantly increased until POD28. These results suggest that prolonged thrombocytopenia after LDLT was associated with not only a decrease in ADAMTS13 due to sinusoidal endothelial cell injury, but also low TPO The online version of the original article can be found under

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Lethal hepatic infarction following plasma exchange in living donor liver transplant patients

Cited by 4 publications

References 8 publications

Platelets Activation and Liver Transplantation

Platelets Activation and Liver Transplantation

Prolonged thrombocytopenia after living donor liver transplantation is a strong prognostic predictor irrespective of history of splenectomy: the significance of ADAMTS13 and graft function

Erratum to: Prolonged thrombocytopenia after living donor liver transplantation is a strong prognostic predictor irrespective of history of splenectomy: the significance of ADAMTS13 and graft function

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