Letinula edodes (Berk.) Pegler (Shiitake) modulates genotoxic and mutagenic effects induced by alkylating agents in vivo

Lima, Patrı́cia Lepage Alves de; Delmanto, Roberta Denadai; Sugui, Marina Mariko; Eira, Augusto Ferreira da; Salvadori, Daisy Maria Fávero; Speit, Günter; Ribeiro, Lúcia Regina

doi:10.1016/s1383-5718(01)00215-7

Cited by 31 publications

(17 citation statements)

References 20 publications

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“…A. blazei fed in dry powdered form to Wister rats at 10% of the diet exhibited significant chemopreventive influence on the promoting phase of the rat chemical hepatocarcinogenesis 36) . Similar antimutagenic effects were reported for diets containing powder of other mushroom Lentinula edodes 37,38) . It was observed that the NK cell activity was maintained at a more significant level in the gynecological cancer patient groups undergoing chemotherapy when A. blazei was orally consumed.…”

supporting

confidence: 80%

Therapy of Myeloma In Vivo Using Marine Phospholipid in Combination with Agaricus blazei Murill as an Immune Respond Activator

Murakawa

Fukunaga

Tanouchi³

et al. 2007

J. Oleo Sci.

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supporting

confidence: 80%

Therapy of Myeloma In Vivo Using Marine Phospholipid in Combination with Agaricus blazei Murill as an Immune Respond Activator

Murakawa

Fukunaga

Tanouchi³

et al. 2007

J. Oleo Sci.

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“…In our previous article, 4 we reported that an aqueous extract obtained at 60°C from L. edodes fruiting bodies (strain 96/17) modulates the mutagenic effect induced chemically by CP and ENU in bone marrow PCEs as well as in peripheral blood RETs. That study also gave us an indication of one of the possible antimutagenic actions.…”

Section: Discussionmentioning

confidence: 96%

“…4 Thus, assessing some different possibilities and using the same in vivo system, this study investigated how Lentinula edodes (Berk.) Pegler [ = Lentinus edodes (Berk.)…”

Section: Introduction Dmentioning

confidence: 99%

Lentinula edodes (Shiitake) Modulates Chemically Induced Mutagenesis by Enhancing Pitting

Lima

Sugui

Petrício

et al. 2013

Journal of Medicinal Food

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This study was undertaken to understand how Lentinula edodes modulates in vivo mutagenesis induced by alkylating agents in bone marrow and peripheral blood as described in our previous article. Male Swiss mice were pretreated for 15 consecutive days with aqueous extracts prepared from L. edodes, after which, the number of circulating blood cells, normal erythroid bone marrow cell cycling, and phagocytosis of micronucleated reticulocyte (MNRET) and activation of spleen macrophages were assessed. The results indicate that the antimutagenicity seen in bone marrow and peripheral blood is exerted by distinct compounds with different actions. The antimutagenic effect in bone marrow is exerted by compounds subject to degradation at deep-freeze storage temperature of -20°C. On the other hand, compounds responsible for antimutagenicity in peripheral blood are not subject to degradation at -20°C. The results also indicate that the antimutagenic action in peripheral blood leading to the reduction of circulating MNRET occurs in the spleen primarily through a phagocytic activity due to higher macrophage numbers and probably not due to the enhanced activation state of individual cells.

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“…Diferentes funções biológicas desses polímeros foram analisadas, como hipoglicemiantes, antitrombóticas, antibióticas, atividades anti-tumorais e anti-virais, atuação na diminuição da pressão arterial e na concentração de lipídios sanguíneos, na inibição da ação inflamatória e microbiana (ALQUINI et al, 2004;HwANg et al, 2003;ZHANG et al, 2000ZHANG et al, , 2007. Estudos com os basidiomicetos Agaricus blazei e Lentinus edodes, utilizados na medicina popular japonesa e chinesa para prevenção e tratamento de doenças, mostraram que essas atividades poderiam estar ligadas aos polissacarídeos presentes nestes fungos (CHEN; SHAO;SU, 2004;DELMANTO et al, 2001;LIMA et al, 2001). …”

Section: Atividades Biológicas Dos Polissacarídeos De Parede Celular unclassified

Polissacarídeos de parede celular fúngica: purificação e caracterização

et al. 2009

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ResumoA parede celular é uma estrutura rígida, essencial para a sobrevivência dos fungos, e o conhecimento de sua composição poderá ser útil para o desenvolvimento de novas drogas antifúngicas. Neste contexto, os polissacarídeos estão entre os seus principais componentes que têm sido alvos de intensa investigação científica. As informações, provenientes do conhecimento da estrutura dessas macromoléculas, poderão ser valiosas para o entendimento dos mecanismos de síntese da parede celular de fungos causadores de patologias, tanto em plantas quanto em animais. A determinação da estrutura química de um endopolissacarídeo deve ser precedida por experimentos de extração e purificação. As extrações, geralmente conduzidas em soluções aquosas neutras e/ou alcalinas, separaram as biomoléculas em grupos, de acordo com suas solubilidades. Os extratos, contendo mistura de polissacarídeos, podem ser purificados pela combinação de métodos químicos e cromatográficos. Após purificação, os polissacarídeos considerados homogêneos são caracterizados estruturalmente com as técnicas convencionais em química de carboidratos tais como hidrólise, metilação, FT-IR e RMN- 13C e 1 H. Esta revisão tem como proposta efetuar um levantamento das principais investigações científicas conduzidas com o objetivo de caracterizar polissacarídeos da parede celular fúngica. Palavras-chave: Biomassa, parede celular fúngica, polissacarídeos, caracterização química AbstractThe cell wall is a rigid structure essential for the survival of fungi. A knowledge of its composition is therefore useful for the development of novel anti-fungal drugs. In this context, polysaccharides as main components of the fungal cell wall have been the subject of intense scientific study over the years. The information gained from the knowledge of the structure of these macrobiomolecules could therefore be valuable in elucidating the mechanisms of their biosynthesis in the cell walls of pathogenic fungi infecting plants and animals alike. Determination of the chemical structures of these polysaccharides (endo) is preceded by their extraction and purification. The extractions, generally lead to neutral and/ or alkaline soluble biopolymers in groups according to their solubilities. Mixtures of polysaccharides in these extracts can then be purified by a combination of chemical and chromatographic methods.

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Letinula edodes (Berk.) Pegler (Shiitake) modulates genotoxic and mutagenic effects induced by alkylating agents in vivo

Cited by 31 publications

References 20 publications

Therapy of Myeloma In Vivo Using Marine Phospholipid in Combination with Agaricus blazei Murill as an Immune Respond Activator

Therapy of Myeloma In Vivo Using Marine Phospholipid in Combination with Agaricus blazei Murill as an Immune Respond Activator

Lentinula edodes (Shiitake) Modulates Chemically Induced Mutagenesis by Enhancing Pitting

Polissacarídeos de parede celular fúngica: purificação e caracterização

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