Letter in response to “The Vitamin B12 analog cobinamide is an effective hydrogen sulfide antidote in a lethal rabbit model”

Cardiogenic shock induced reduction in cellular O2delivery as a hallmark of acute H2S intoxication

“…Fernandes et al (4) have recently argued that this mechanism is difficult to reconcile with the data published by Brenner et al (5) depicting a drop , instead of an increase , in “tissular” oxyhemoglobin during sulfide intoxication, i.e. in the setting of an inhibition of oxidative phosphorylation.…”