Letter: opioid usage is associated with rectal hyposensitivity in patients with opioid‐induced constipation

Vollebregt, Paul F.; Knowles, Charles H.

doi:10.1111/apt.17381

Aliment Pharmacol Ther

2023

DOI: 10.1111/apt.17381

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Letter: opioid usage is associated with rectal hyposensitivity in patients with opioid‐induced constipation

Paul F. Vollebregt

Charles H. Knowles

Abstract: LINKED CONTENTThis article is linked to Cash et al paper. To view this article, visit https://doi.org/10.1111/apt.16702

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2024

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Electroacupuncture inhibited carrageenan-induced pain aversion by activating GABAergic neurons in the ACC

Zhu,

Sun,

Xiao

et al. 2024

Mol Brain

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Pain aversion is an avoidance response to painful stimuli. Previous research has indicated that the anterior cingulate cortex (ACC) is involved in pain aversion processing. However, as interneurons, the role of GABAergic neurons in the ACC (GABAACC neurons) in pain aversion is still unclear. Electroacupuncture (EA) has been shown to ameliorate pain aversion, but the mechanism is not clarified. The present study provided evidence that inhibition of GABAACC neurons contributed to pain aversion. EA alleviated pain aversion by activating GABAACC neurons in an intensity-dependent manner. Specifically, 0.3 mA EA stimulation showed better effects on pain aversion than 0.1 mA stimulation, which could be reversed by chemical genetic inhibition of GABAACC neurons. These results provide a novel mechanism by which EA alleviates pain aversion by reversing GABAACC neurons.

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Electroacupuncture inhibited carrageenan-induced pain aversion by activating GABAergic neurons in the ACC

Zhu,

Sun,

Xiao

et al. 2024

Mol Brain

View full text Add to dashboard Cite

show abstract

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Letter: opioid usage is associated with rectal hyposensitivity in patients with opioid‐induced constipation

Abstract: LINKED CONTENTThis article is linked to Cash et al paper. To view this article, visit https://doi.org/10.1111/apt.16702

Cited by 1 publication

References 9 publications

Electroacupuncture inhibited carrageenan-induced pain aversion by activating GABAergic neurons in the ACC

Electroacupuncture inhibited carrageenan-induced pain aversion by activating GABAergic neurons in the ACC

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