Editors,We would like to express our gratitude to Huang et al for their insightful comments on our study. 1,2 In response to the first query, we agree that fatty liver may be associated with the risk of chronic kidney disease (CKD) development. The number of patients with fatty liver by imaging studies such as ultrasonography was 191 (18.3%), 528 (19.7%), 172 (22.7%) and 1376 (22.3) in the entecavir, tenofovir disoproxil fumarate (TDF), tenofovir alafenamide (TAF) and untreated group, respectively.