Letter regarding Wang et al. entitled “Effects of murine double minute 2 polymorphisms on the risk and survival of osteosarcoma: a systemic review and meta-analysis”

Liu, Guoyan; Xu, Weiqing; Hao, Yanke; Xu, Zuojun

doi:10.1007/s13277-013-1505-5

Cited by 3 publications

(6 citation statements)

References 3 publications

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“…In agreement with Liu et al [2], we also think that further studies with large samples are still needed to assess the effects of MDM2 polymorphisms on the risk and survival of osteosarcoma.…”

supporting

confidence: 91%

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Letter regarding Wang et al. entitled “Effects of murine double minute 2 polymorphisms on the risk and survival of osteosarcoma: a systematic review and meta-analysis”

2014

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We have read with interest the article by Wang et al. [1] in a recent issue of Tumor Biology. In this study, the authors conducted a systematic review and meta-analysis to assess the effects of two murine double minute 2 (MDM2) polymorphisms, rs2274799 and rs160916, on the risk and survival of osteosarcoma. The authors concluded that MDM2 polymorphisms had effects on the risk but had no effect on the survival of patients with osteosarcoma. In a recent letter to the editor, Liu et al. [2] detected several weaknesses in the meta-analysis. Firstly, they criticize the small number of papers included in the analyses, which could lead to false significant associations. They also point out the lack of information in the methods used to select the studies. Moreover, they comment the absence of Hardy-Weinberg equilibrium analysis in the control population. Finally, they question the quality of the selected studies. In the present letter, we would like to add some other inaccuracies found in the Wang et al.[1] meta-analysis.According to our analyses, there is no association between MDM2 rs2279744 and osteosarcoma risk in the population used by Ito et al. [3]. This contradicts the result shown by Wang et al. [1] in their study. When we calculate the odds ratio (OR) value of Ito et al. [3] samples, using the total of benign tumors (n=37) as controls, we obtain a different OR value. This contradictory result has been observed in all hereditary models (allele model, OR=1.46, codominant model, OR=1.50, recessive model, OR 1.11, dominant model, OR=1.88,

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supporting

confidence: 91%

“…The authors concluded that MDM2 polymorphisms had effects on the risk but had no effect on the survival of patients with osteosarcoma. In a recent letter to the editor, Liu et al [2] detected several weaknesses in the meta-analysis. Firstly, they criticize the small number of papers included in the analyses, which could lead to false significant associations.…”

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confidence: 99%

Letter regarding Wang et al. entitled “Effects of murine double minute 2 polymorphisms on the risk and survival of osteosarcoma: a systematic review and meta-analysis”

2014

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“…Since these negative results were different from previous published results, we decided to perform a deep revision of data published in the literature and realized a new meta-analysis. The results showed no association, in contrast to another metaanalysis previously published, (13) in which some inaccuracies were detected (14,15). The differences between both metaanalyses could be due to the fact that our study included two new populations, but they can also be explained because different data from the original articles were selected.…”

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confidence: 84%

Section: Systematic Review Nature Publishing Groupmentioning

confidence: 99%

“…Nevertheless, some inaccuracies were detected in the study. Among others, the lack of information in the methods used to select the studies and extract the genotyping data and the inclusion of other types of bone tumors in the meta-analysis (not only OS) (14,15).Therefore, this study aimed to clarify the possible association between MDM2 rs1690916 and rs2279744, and risk of OS. We initially analyzed the effect of both polymorphisms in two new independent cohorts of OS patients (Spanish and Slovenian) and performed a new updated meta-analysis following the recommended guidelines published (16).…”

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A systematic review and meta-analysis of MDM2 polymorphisms in osteosarcoma susceptibility

et al. 2016

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Two polymorphisms in the murine double minute 2 (MDM2) gene (rs1690916 and rs2279744) have been associated with the risk of osteosarcoma (OS). When we analyzed these two polymorphisms in two new independents cohorts (Spanish and Slovenian), we found no association. In order to clarify this, we conducted a meta-analysis including six populations, with a total of 246 OS patients and 1,760 controls for rs1690916; and 433 OS patients and 1,959 controls for rs2279744. Pooled odds ratio risks and corresponding 95% CI were estimated to assess the possible associations. Our results showed that these two polymorphisms were not associated with the susceptibility of OS under any genetic model studied. In conclusion, the present meta-analysis indicates that MDM2 rs1690916 and rs2279744 cannot be considered as genetic risk factors for OS susceptibility in the different populations. Therefore, the influence of these two polymorphisms on the risk of OS may be less important than previously suggested. Future studies are needed to confirm these results.O steosarcoma (OS) is the most common primary malignant tumor of bone, mainly occurring in the second decade of life. The precise etiology of the disease remains partially unknown (1). Nevertheless, genetic factors might play a key role in its pathogenesis (2). To date diverse studies have reported associations of common genetic variants in biologically plausible pathways with OS risk (3-6). Among the analyzed variants, rs1690916 and rs2279744 in the murine double minute 2 gene (MDM2) are two of the most recurrently studied and associated with the susceptibility of OS (5,7-9). The MDM2 gene is especially interesting because it functions as an E3 ubiquitin ligase promoting p53 degradation (10,11).MDM2 rs1690916, located at the 3′ untranslated region of the gene, was significantly associated with the risk of OS in a large North-American population including 96 patients and 1,416 controls (7). They found that rs1690916 AA genotype decreased the risk of the disease. rs1690916 A allele was also found to be associated with a decreased risk of bone tumors in Russian population including 68 patients and 86 controls (9). However, this study only included 26 OS patients out of 68 analyzed. MDM2 rs2279744, situated in the promoter region, was related to an increased risk of OS (GG vs. TT) in Italian population (211 OS patients and 250 controls) (5), being this association stronger in females. Moreover, a robust correlation between rs2279744 G allele enrichment and MDM2 amplification was found, suggesting the contribution of this polymorphism to OS tumorigenesis (12). However, this single nucleotide polymorphism (SNP) did not show any association in the North-American population (7). A meta-analysis evaluating the association between these two polymorphisms and the risk of OS was performed, concluding that both SNPs influence the risk of OS (13). Nevertheless, some inaccuracies were detected in the study. Among others, the lack of information in the methods used to select the studies and extr...

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Osteosarkoma pediatrikoarekiko suszeptibilitatean inplikatuta dauden aldaera genetikoak

Bilbao-Aldaiturriaga¹,

Gutiérrez-Camino²,

Garcı́a-Orad³

et al. 2018

EKAIA

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Laburpena: Osteosarkoma (OS) edo sarkoma osteogenikoa gazteen artean gertatzen den hezur-minbizirik ohikoena da. Adin hain goiztiarretan sortzeak adierazten du haren jatorrian genetikak paper garrantzitsua duela. Izan ere, hainbat ikerketa-lanen arabera, sarkortasun txikiko aldaera genetikoak (SNPak, esaterako) OSaren kausa izan ohi dira. Jakina da beste minbizi mota batzuetan aldaera genetikoek gaixotasun horrekiko suszeptibilitatean eragina izaten dutela. miRNAk dira minbizien jatorri eta bilakaeran gehien aztertu diren RNA ez-kodetzaileak (ncRNA). Hori dela eta, bai gune kodetzaileetan bai ez-kodetzaileetan (miRNAk eta hauek prozesatzen dituzten geneak) zen aldakortasun genetikoa aztertu genuen. Lan honetan, OSarekiko suszeptibilitatean eragina duten aldaera genetikoen bilaketa egin genuen. Gure emaitzek CTLA4 genea eta 14q32 guneko miRNA taldeak OSarekiko suszeptibilitatearen hotspot-ak izan daitezkeela erakusten dute.Hitz gakoak: osteosakoma, SNP, suszeptibilitatea eta miRNA.Abstract: Osteosarcoma (OS) is the most common primary bone cancer that occurs primarily in children, adolescents, and young adults. The fact that OS occurs at an early age suggests that there is a strong genetic component at its source. Several studies have suggested that susceptibility to OS development is due to small common low-pene-

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Letter regarding Wang et al. entitled “Effects of murine double minute 2 polymorphisms on the risk and survival of osteosarcoma: a systemic review and meta-analysis”

Cited by 3 publications

References 3 publications

Letter regarding Wang et al. entitled “Effects of murine double minute 2 polymorphisms on the risk and survival of osteosarcoma: a systematic review and meta-analysis”

Letter regarding Wang et al. entitled “Effects of murine double minute 2 polymorphisms on the risk and survival of osteosarcoma: a systematic review and meta-analysis”

A systematic review and meta-analysis of MDM2 polymorphisms in osteosarcoma susceptibility

Osteosarkoma pediatrikoarekiko suszeptibilitatean inplikatuta dauden aldaera genetikoak

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