Letter to the editor: +2.71 LOD score at zero recombination is not sufficient for establishing linkage between X-linked mental retardation and X-chromosome markers

Robledo, Renato; Melis, Paola; Siniscalco, M.; Marchi, Jula; Laficara, Francesco; Rinaldi, A; Rocchi, Mariano; Filippi, Giorgio

doi:10.1002/(sici)1096-8628(19960712)64:1<134::aid-ajmg23>3.0.co;2-n

Cited by 5 publications

(2 citation statements)

References 7 publications

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“…Those males with XLMR who lack physical, behavioral, or neurological findings should be designated as having "nonsyndromic (or "nonspecific") XLMR," at least in the short term, until the responsible genes are isolated. Robledo et al (1994) reported evidence for linkage of RENS1 to markers in both Xp11.23-p11.3 and Xq21.33-Xq26, in a family previously reported by Ar-…”

Section: Discussionmentioning

confidence: 69%

Renpenning Syndrome Maps to Xp11

Stevenson

Arena

Ouzts

et al. 1998

The American Journal of Human Genetics

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Mutations in genes on the X chromosome are believed to be responsible for the excess of males among individuals with mental retardation. Such genes are numerous, certainly >100, and cause both syndromal and nonsyndromal types of mental retardation. Clinical and molecular studies have been conducted on the Mennonite family with X-linked mental retardation (XLMR) reported, in 1962, by Renpenning et al. The clinical phenotype includes severe mental retardation, microcephaly, up-slanting palpebral fissures, small testes, and stature shorter than that of nonaffected males. Major malformations, neuromuscular abnormalities, and behavioral disturbances were not seen. Longevity is not impaired. Carrier females do not show heterozygote manifestations. The syndrome maps to Xp11.2-p11.4, with a maximum LOD score of 3.21 (recombination fraction 0) for markers between DXS1039 and DXS1068. Renpenning syndrome (also known as "MRXS8"; gene RENS1, MIM 309500) shares phenotypic manifestations with several other XLMR syndromes, notably the Sutherland-Haan syndrome. In none of these entities has the responsible gene been isolated; hence, the possibility that two or more of them may be allelic cannot be excluded at present.

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Section: Discussionmentioning

confidence: 69%

Renpenning Syndrome Maps to Xp11

Stevenson

Arena

Ouzts

et al. 1998

The American Journal of Human Genetics

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“…Analysis of recombinatorial events indicated a position between DXS1201 and DXS1204 (Xp11.22‐Xp11.4). The enigmatic finding that a significant positive LOD score was obtained for marker DXS132 located outside the Xp11 candidate region is possibly due to the occurrence of a double recombination event between the disease locus and DXS132 [see also Robledo et al, 1994] or a mutation. Moreover, because significant negative LOD scores were obtained for several markers located very close to DXS132, it is very unlikely that the MRX9 disease gene is located in this region.…”

Section: Discussionmentioning

confidence: 99%

Effect of surface modification of glass wool on the mechanical and electrical properties of polypropylene/modified glass‐wool composites

Turky¹,

El-Reheim²,

Badran³

2002

J of Applied Polymer Sci

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ABSTRACT:The surface of glass wool (GW) was modified by two different methods, either by grafting methyl acrylate (MA) onto GW in the presence of potassium persulfate (PPS) as initiator, or by adsorbing stearic acid (AS) as surface active agent onto the GW surface. It was found that conversion and grafting yield of poly(methyl acrylate) (PMA) onto the GW surface increased with increasing initiator concentration, whereas by modifying the GW surface by adsorption of SA, the adsorption of SA was found to be high at small values of equilibrium concentrations and two distinct plateau regions were observed. Mechanical and electrical properties of polypropylene (PP) sheets loaded with modified GW were measured. The obtained data showed that the presence of PMA as grafted polymer onto the GW surface has a plasticizing effect on the prepared PP composites. On the other hand, SA, as a surface modifier for GW, acts as a reinforcing agent for the formed PP composites, which have very good dielectric properties. From the obtained results, one can deduce that the prepared PP/GW composites have promising dielectric properties.

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Giorgio Filippi, April 4, 1935-January 19, 1996

Siniscalco

1997

Am. J. Med. Genet.

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Letter to the editor: +2.71 LOD score at zero recombination is not sufficient for establishing linkage between X-linked mental retardation and X-chromosome markers

Cited by 5 publications

References 7 publications

Renpenning Syndrome Maps to Xp11

Renpenning Syndrome Maps to Xp11

Effect of surface modification of glass wool on the mechanical and electrical properties of polypropylene/modified glass‐wool composites

Giorgio Filippi, April 4, 1935-January 19, 1996

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