Letter to the Editor

Cp, Jerome; Cs, Carlson; Mj, Jayo; Tc, Register; Ds, Weaver; Cj, Lees; Mr, Adams

doi:10.1016/s0169-6009(08)80175-4

Cited by 4 publications

(1 citation statement)

References 10 publications

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“…In particular, Jerome et al5 have shown that OVX cynomolgus monkeys are an excellent model for studying the basic mechanism of postmenopausal osteoporosis and for the development of suitable therapeutic regimens. Peak bone mass is reached in female cynomolgus monkeys at 9 years of age,6 2-3 years after growth plate closure, and animals older than this age would be an ideal for studies designed to model skeletally mature women 7. The lumbar spine has been most frequently studied in cynomolgus monkeys by measuring bone mineral density (BMD) using dual energy X-ray absorptiometry (DXA) 8.…”

Section: Introductionmentioning

confidence: 99%

Influence of Ovariectomy on Bone Turnover and Trabecular Bone Mass in Mature Cynomolgus Monkeys

Iwamoto

Seki

Matsuura³

et al. 2009

Yonsei Med J

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PurposeTo examine the influence of ovariectomy (OVX) on bone turnover and trabecular bone mass at the 3 clinically important skeletal sites in mature cynomolgus monkeys.Materials and MethodsSix female cynomolgus monkeys, aged 17-21 years, were randomized into 2 groups by the stratified weight: the OVX and sham-operation groups (n = 3 in each group). The experimental period was 16 months. Lumbar bone mineral density (BMD) in vivo and serum and urinary bone turnover markers were longitudinally measured, and peripheral quantitative computed tomographic and bone histomorphometric analyses were performed on trabecular bone of the lumbar vertebra, femoral neck, and distal radius at the end of the experiment.ResultsOVX induced in a reduction in lumbar BMD compared with the sham controls and the baseline, as a result of increased serum levels of bone-specific alkaline phosphatase and urinary levels of cross-lined N- and C-terminal telopeptides of type I collagen. Furthermore, OVX induced reductions in trabecular volumetric BMD and trabecular bone mass compared with the sham controls, with increased bone formation rate at the lumbar vertebra, femoral neck, and distal radius.ConclusionThe results indicated that OVX in mature cynomolgus monkeys (17-21 years of age) increased bone turnover and induced trabecular bone loss at the three skeletal sites compared with the sham controls. Thus, mature cynomolgus monkeys could be utilized for preclinical studies to examine the effects of interventions on bone turnover and trabecular bone mass at the 3 clinically important skeletal sites.

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Section: Introductionmentioning

confidence: 99%

Influence of Ovariectomy on Bone Turnover and Trabecular Bone Mass in Mature Cynomolgus Monkeys

Iwamoto

Seki

Matsuura³

et al. 2009

Yonsei Med J

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Determining isotopic life history trajectories using bone density fractionation and stable isotope measurements: A new approach

Bell

Cox

Sealy

2001

American J Phys Anthropol

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A number of recent studies have attempted to trace diet at different stages of an individual's life by comparing isotope ratios of bone from different gross anatomical sites within the skeleton. In this study we develop this approach further by separating bone of differing mineral densities within one skeletal element, where each density fraction represents a different period of time. Isotope ratios are measured for these fractions. Each density fraction represents a period of bone formation and maturation, where younger (more recently formed) bone is less well-mineralized and therefore less dense than relatively older packets of bone. In an adult, bone is therefore able to partition approximately the last 15 years of life. Bone fractions were recovered by stepped ultracentrifugation in a series of organic solvents of increasing density, and then collagen was recovered by decalcification in dilute acid, and stable carbon isotope ratios ((13)C/(12)C) were measured. Bone density microstructure was checked for bacterial remodelling using backscattered electron imaging in a scanning electron microscope. Our results indicate that the bone density fractionation method is applicable to archaeological material, here extending to a maximum of 5,000 years BP, and that collagen can successfully be extracted from such fractions. The carbon isotope values for bone fractions of different densities patterned out as expected in one modern control bone and in specimens from five archaeological human skeletons, including three precolonial hunter-gatherers and two 18th/19th century individuals. The latter two are known (from previous assessments) to have undergone marked changes in diet during their lifetimes. Postmortem alteration was evident in some of the specimens examined. The bone density fractionation approach has allowed greater resolution of diet than has hitherto been possible and has provided access to the elusive last years and months of an individual's life.

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Changes in Cortical Bone Mineral and Microstructure with Aging and Osteoporosis

Yerramshetty

Akkuş

2012

Studies in Mechanobiology, Tissue Engineering and Biomaterials

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Letter to the Editor

Cited by 4 publications

References 10 publications

Influence of Ovariectomy on Bone Turnover and Trabecular Bone Mass in Mature Cynomolgus Monkeys

Influence of Ovariectomy on Bone Turnover and Trabecular Bone Mass in Mature Cynomolgus Monkeys

Determining isotopic life history trajectories using bone density fractionation and stable isotope measurements: A new approach

Changes in Cortical Bone Mineral and Microstructure with Aging and Osteoporosis

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