Letter to the editor – <scp>HPV</scp> vaccine and autoimmunity Incidence of new‐onset autoimmune disease in girls and women with pre‐existing autoimmune disease after quadrivalent human papillomavirus vaccination: a cohort study

Dahan, Shani; Shoenfeld, Yehuda

doi:10.1111/joim.12575

Cited by 7 publications

(3 citation statements)

References 29 publications

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“…81,82 Whereas some studies present no association between HPV vaccines and autoimmune adverse events, [83][84][85][86] others have addressed the significant limitations of many of these analyses. 87,88 The answer remains largely disputed, yet the attention drawn to HPV may be responsible for some intriguing discoveries regarding potential molecular mimicry between HPV and human proteins. In two comprehensive analyses Kanduc et al 9,89 exposes vast peptide overlap between peptides of HPV to the human proteome, 90 thus laying the grounds for further research regarding HPV and autoimmunity.…”

Section: Human Papilloma Virus Vaccines: a Veil Of Concern Remains Unmentioning

confidence: 99%

Vaccine-induced autoimmunity: the role of molecular mimicry and immune crossreaction

2018

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Since the early 1800s vaccines have saved numerous lives by preventing lethal infections. However, during the past two decades, there has been growing awareness of possible adverse events associated with vaccinations, cultivating heated debates and leading to significant fluctuations in vaccination rates. It is therefore pertinent for the scientific community to seriously address public concern of adverse effects of vaccines to regain public trust in these important medical interventions. Such adverse reactions to vaccines may be viewed as a result of the interaction between susceptibility of the vaccinated subject and various vaccine components. Among the implicated mechanisms for these reactions is molecular mimicry. Molecular mimicry refers to a significant similarity between certain pathogenic elements contained in the vaccine and specific human proteins. This similarity may lead to immune crossreactivity, wherein the reaction of the immune system towards the pathogenic antigens may harm the similar human proteins, essentially causing autoimmune disease. In this review, we address the concept of molecular mimicry and its application in explaining post vaccination autoimmune phenomena. We further review the principal examples of the influenza, hepatitis B, and human papilloma virus vaccines, all suspected to induce autoimmunity via molecular mimicry. Finally, we refer to possible implications on the potential future development of better, safer vaccines.

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Section: Human Papilloma Virus Vaccines: a Veil Of Concern Remains Unmentioning

confidence: 99%

Vaccine-induced autoimmunity: the role of molecular mimicry and immune crossreaction

2018

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“…We read the recent correspondence by Drs Dahan and Shoenfeld [1] with confusion and concern. A response by Gronlund et al [2] very adroitly addressed several of the concerns of Dahan and Shoenfeld by undertaking re-analysis of their data.…”

Section: Dear Sirmentioning

confidence: 99%

Response to: HPV vaccine and autoimmunity Incidence of new‐onset autoimmune disease in girls and women with pre‐existing autoimmune disease after quadrivalent human papillomavirus vaccination: a cohort study

Hawkes¹,

Wilkinson²,

Dunlop³

2017

J Intern Med

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“…15,16 In contrast, HPV vaccination significantly reduced the prevalence of RA in adults aged 18 to 59 years. 12 Because of the amino acid sequence similarity between HPV antigen and numerous human proteins, 17,18 HPV-47 E2345-362 peptide has homology with the epitope of RA autoantigen; thus, HPV-induced autoantibodies against viral antigen promoted pathogenesis of RA. 12 An observational study found that 33% of patients with RA had HSV I and HSV II DNA in both their blood and synovial fluid samples.…”

mentioning

confidence: 99%

Association Between Herpes Simplex Virus II Infection and Rheumatoid Arthritis in US Adults

Fu,

Lin,

Chang

2023

J Clin Rheumatol

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Background/Objective The potential correlation between herpes simplex virus (HSV) and human papillomavirus (HPV) infections and rheumatoid arthritis (RA) has not been definitively established. Further research is needed to determine the relationship between the development of RA and the presence of these viral infections. Methods A retrospective case-control study was conducted with data from the National Health and Nutrition Examination Survey between 2009 and 2014. Our analysis examined the association between HSV I, HSV II, HPV oral polymerase chain reaction (PCR), HPV vaginal PCR, and RA. We identified adults aged 20 to 49 years with a primary diagnosis of RA using the National Health and Nutrition Examination Survey database codes (MCQ191 = 1 [years 2009–2010]; MCQ195 = 2 [years 2011–2014]) and excluded patients with incomplete data on key variables and primary outcomes. Results The study included 8620 patients, with 150 patients diagnosed with RA and 1500 patients without RA. Patients with RA had a significantly higher prevalence of HSV II infection compared with those without RA (36.34% vs. 24.72%, p = 0.015) after propensity score matching. No significant differences were observed for HSV I, HPV oral PCR, and HPV vaginal PCR between the 2 groups. Patients with RA were older; were more likely to be female, obese, and non-Hispanic White; and had a higher prevalence of comorbidities than those without RA. Conclusions This population-based propensity score–matching study provides evidence of an association between HSV II infection and RA in US adults. Further research is needed to fully elucidate the relationship between viral infections and RA, with the aim of developing effective risk reduction strategies and innovative treatments for RA.

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Letter to the editor – HPV vaccine and autoimmunity Incidence of new‐onset autoimmune disease in girls and women with pre‐existing autoimmune disease after quadrivalent human papillomavirus vaccination: a cohort study

Abstract: http://onlinelibrary.wiley.com/doi/10.1111/joim.12574/abstract.

Cited by 7 publications

References 29 publications

Vaccine-induced autoimmunity: the role of molecular mimicry and immune crossreaction

Vaccine-induced autoimmunity: the role of molecular mimicry and immune crossreaction

Response to: HPV vaccine and autoimmunity Incidence of new‐onset autoimmune disease in girls and women with pre‐existing autoimmune disease after quadrivalent human papillomavirus vaccination: a cohort study

Association Between Herpes Simplex Virus II Infection and Rheumatoid Arthritis in US Adults

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