2021
DOI: 10.1136/jitc-2020-002216
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Letter to the editor: Checking the pulse of adoptive cell therapy for solid tumors. Thoughts from the abstracts submitted to the 35th Annual Meeting of the Society for the Immunotherapy of Cancer (SITC 2020)

Abstract: Adoptive cell therapy (ACT) for the treatment of solid malignancies has not met yet the success of hematological malignancies. This is due to additional roadblocks peculiar to its deployment for the former application. While T-cell fitness stands as a prerequisite for all purposes of ACT, selection of optimal tumor-specific antigens, efficient trafficking to neoplastic tissues, and overcoming immune exclusion and/or suppression are challenges pertaining predominantly to solid malignancies. To gain insights abo… Show more

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